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SAN DIEGO (KGTV) — Border Patrol agents arrested five people in connection with a human smuggling incident, including one man convicted of being a sexual predator.A vehicle traveling through a temporary immigration checkpoint in Potrero failed to stop at about 6:30 a.m. Wednesday, according to U.S. Customs and Border Protection, before agents stopped the vehicle several yards past the checkpoint.Agents say five males in the vehicle were questioned. Three passengers in the vehicle's backseat said they were from Mexico but had no U.S. documentation, according to CBP. The driver and front seat passenger claimed to be from the U.S.The driver and front passenger were arrested on suspicion of smuggling and the three other passengers were arrested for being in the U.S. illegally, CBP said. During a records check at a nearby station, agents learned one passenger, a 39-year-old Mexican national, was convicted in 2012 of kidnapping and rape of a minor in San Diego. He was sentenced to a seven-year prison term and removed from the U.S.“I am proud of the great work agents demonstrated in arresting this known child predator,” said Chief Patrol Agent Douglas Harrison. “Their actions help keep our communities safer.”Both U.S. citizens face human smuggling charges and the previously deported Mexican man faces federal charges. The two other passengers will be processed for removal from the country. 1413

SAN DIEGO (KGTV) -- Caltrans maintenance crews closed the westbound Interstate 8 connector to northbound state Route 67 at 9 p.m. Thursday night, but lanes were reopened at 5 a.m. Friday morning. The closure took effect for guardrail repair, according to Caltrans.Signs were posted to direct motorists on westbound I-8 to exit at West Main Street and turn left to eastbound I-8 to SR-67.Motorists were reminded to be work zone alert and slow down when approaching Caltrans vehicles with amber flashing lights.Caltrans says Californians can expect more roadway improvement projects like this made possible by the recently passed Road Repair and Accountability Act of 2017, Senate Bill 1.  715

SAN DIEGO (KGTV) — COVID-19 related hospitalizations are on the rise in San Diego County and some healthcare workers are worried we will continue to see a significant increase over the next several weeks to months.“We’re actually seeing significant increases,” said Dr. Ghazala Sharieff, Scripps Health Chief Medical Officer for Clinical Excellence and Experience. “We’re actually higher than we were back in July. Yesterday alone the numbers we got from the county we had 532 hospitalizations across the region.”The total number of positive COVID-19 cases in the county is now 75,305. According to county data, 4,470 of all COVID-19 cases have required hospitalization, and 1,006 had to be admitted to an intensive care unit.Sharieff said Wednesday at Scripps campuses, more than 100 people were hospitalized with COVID-19.“We had 117 cases that is with 16 discharges, so if we weren’t able to send home those patients yesterday, we would be at our peak level in July,” she said.She said the concern is growing from those in the medical field, not only after local Halloween parties locally, but as we enter Thanksgiving and the next several holidays.She expects the numbers to continue climbing into early 2021.“What we’re seeing now is what we have predicted,” she said. “We do worry that two or three weeks out from now that we’re going to see the number increase as well.New Year’s Eve is December 31st; if you calculate just exactly what we’re seeing now, people start getting sick in that first two weeks, because the incubation period is two to fourteen days after exposure, then they get really sick and hospitalized, and then the intensive care unit comes, so I’m very worried.”Like many healthcare systems, she says Scripps is seeing a surge in hospitalizations countywide, but even more in the South Bay, where Covid-19 has hit the community hard.Scripps has a detailed plan in place and has managed to balance hospital capacity by transferring patients to different hospitals to not overwhelm a specific location.“Every day, between 4 to 5 patients are getting transferred out of the Chula Vista campus,” she said. “Yesterday we had five transfers, this morning we had two from Chula Vista to Green, and two from Mercy Chula Vista to La Jolla. We don’t want all of the strain to go on our staff in one place when we have capability elsewhere.”“It’s really hard on the healthcare providers when we’re out there trying to save lives, and we see people taking risks like they don’t have to take right now,” she said. “It’s a punch in the gut every time.”Sharieff said the hospitals are well equipped with PPE this time around, but while many people may be letting their guards down and gathering this Thanksgiving, she’s reminding everyone that this pandemic isn’t over and will get worse if we don’t act now.“Just one thing that you do can impact so many lives afterward,” she said. 2901

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) -- City leaders are considering closing some streets in the Gaslamp Quarter to help with social distancing amid the coronavirus pandemic.Pictures on social media showed crowds of people congregating outside bars, many not wearing face coverings, shortly after they reopened Friday.According to a spokesman for San Diego Mayor Kevin Faulconer, the city's department of special events is reviewing a proposal to shut down parts of Fifth Avenue between G and K streets to make it easier to physically distance by providing more room in parts of the public right of way for outdoor dining.The Gaslamp Quarter Association submitted the application, which would close close the streets Thursday, Fridays, and Saturdays. It could be approved and go into effect as soon as this Thursday.Robert Romero owns the Tivoli Bar and Grill. The longtime family-run restaurant on Sixth Avenue reopened Monday. It's the oldest bar in San Diego county."We were open originally in 1881, never have closed in all those years, during the depression, prohibition, World War I, World War Two, until now," said Romero.The owners say they'll be strict about social distancing, face coverings, and increased sanitation protocols."We will have someone at the front door constantly monitoring our customers and making sure they are holding to the restrictions put on us," said Romero.Romero said he noticed many other bars and restaurants were not following the county health orders."It was terrible, when they do that, they're not only reflecting on us, but also putting up the potential for shut down," said Romero.County Health Officials also acknowledged there were problems Friday night after the bars first reopened, but said the city is working to close some streets.California Assemblymember Todd Gloria is also concerned about crowds gathering in the Gaslamp."Part of their reopening is a limited of their capacity, they're operating at a fraction of what they can actually accommodate. Because they were metering the entrance of customers into their businesses, that overflow of customers ends up on the sidewalk," said Assemblymember Gloria.Gloria also thinks closing Fifth Avenue is a good idea."Let's see if there's a way to meet in the middle if you will, these businesses are adhering to the guidelines; the city can certainly help people by closing down the streets, we can be passing out face masks to people who are waiting," said Gloria.Back at Tivoli's, the owners are ready to welcome back customers."Behave, be happy, we love you, they love us and remember, I love it," said Romero, referring to the name Tivoli, spelled backwards. 2648

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