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LONDON (AP) — AstraZeneca and Oxford University have acknowledged a manufacturing error that is raising questions about preliminary results of their COVID-19 vaccine.A statement Wednesday describing the error came days after the company and the university described the shots as “highly effective” and made no mention of why some participants didn’t receive as much vaccine as expected.In a surprise, the group of volunteers that got half a dose in the first of their two shots seemed to be better protected than the volunteers who got full doses. The low-dose group was smaller and younger, however, which could have skewed the results, experts say.In a statement obtained by CNN, Oxford elaborated further, saying that a “difference in the manufacturing process” had led to the error.The university said that it discussed the problem with regulators, agreed to complete the late stage trial with two groups, and the problem has since been corrected. 959

LOS ANGELES (CNS) - Downward trends in coronavirus cases and testing-positivity rates could allow Los Angeles County to move into the next tier of the state's economic-reopening matrix by sometime in October, according to the county's public health director, but pending Labor Day numbers could potentially thwart that move.The county is in the most restrictive, or "purple," level of the state's four-tier virus-tracking roadmap. The county already has a low enough seven-day average testing positivity rate -- around 3.2% -- to move to a less-restrictive tier, but average new case numbers are still too high, currently averaging 8.1 cases per 100,000 residents. The state threshold for advancing to the "red" tier is seven cases per 100,000.However, Public health director Barbara Ferrer said Wednesday numbers in all categories have been trending downward over the past six weeks following a spike seen after the Fourth of July holiday weekend."If we don't see a surge in cases and hospitalizations associated with activities over Labor Day and we continue to reduce our rate of community transmission over the weeks ahead, we could enter tier 2, which is a less restrictive tier, sometime in October," Ferrer said.Health officials have said repeatedly they will not consider any more business reopenings in the county until at least late September, after determining if virus cases and hospitalizations increase following the Labor Day holiday weekend -- the way they did after Memorial Day and the Fourth of July.If the county gets its average new case numbers below seven per 100,000 residents, and maintains that level for two weeks, the county will be able to move into the state's "red" tier. That would allow more businesses to reopen, including potentially movie theaters and gyms, as well as school campuses for in-person learning.Ferrer said the county is now seeing its lowest average testing- positivity rate of the pandemic."Last week, we saw the lowest positivity rate to date, at around 3.4%," she said. "This means that almost 97% of the tests that people took for COVID-19 ended up being negative. Just a month ago, in mid-August, this rate was around 5%. So we're happy to see the progress that we've made and we're very much hoping that this number continues to decrease."She again warned, however, that the impact of the Labor Day holiday weekend has yet to be borne out in case numbers, since the virus has a 14-day incubation period. She also said upcoming fall and winter holidays, including the start of Rosh Hashanah this weekend, could lead to setbacks if people become lax about social distancing and other preventive measures."The autumn and winter months are filled with special times that we all are looking forward to," she said. "There's many secular and religious holidays that we usually celebrate by spending time with our friends and extended family members. And the pandemic has been difficult and frustrating in many ways, including placing limits on how we can celebrate safely. I do encourage all of us to think now about how we might want to modify our plans so we can share the joy of the holidays while reducing the risk of transmitting a dangerous and sometimes deadly virus."She and the county's health services director, Dr. Christina Ghaly, urged people to get a flu shot, noting that as flu season arrives, people who contract both influenza and COVID-19 may be susceptible to severe illness.The county on Wednesday reported 31 coronavirus-related deaths, although one of those fatalities was actually announced Tuesday by health officials in Long Beach. Long Beach announced two additional deaths Wednesday afternoon. The total number of fatalities in the county stood at 6,305 as of Wednesday.The county also announced 1,148 newly confirmed cases, while Long Beach added 40 cases and Pasadena reported six, lifting the cumulative total since the start of the pandemic to 256,194.There were 804 people hospitalized due to COVID-19 in the county, up slightly from Tuesday. Ghaly noted that the sharp downward trend seen in hospitalizations over the past month appears to have slowed or leveled off. But hospitalization numbers till remained at dramatically lower levels than they were a month ago.Ghaly said overall testing numbers over the past week were down, thanks in part due to closures of some testing centers due to poor air quality caused by the region's wildfires. She said some testing sites have two-thirds of their appointment slots available, so she encouraged anyone with symptoms of the coronavirus or who thinks they may have been exposed to get tested. 4630

LOS ANGELES (AP) — Robert Forster, the handsome and omnipresent character actor who got a career resurgence and Oscar nomination for playing bail bondsman Max Cherry in "Jackie Brown," died Friday. He was 78.Publicist Kathie Berlin said Forster died of brain cancer following a brief illness. He was at home in Los Angeles, surrounded by family, including his four children and partner Denise Grayson.Condolences poured in Friday night on social media.Bryan Cranston called Forster a "lovely man and a consummate actor" in a tweet. The two met on the 1980 film "Alligator" and then worked together again on the television show "Breaking Bad" and its spinoff film, "El Camino," which launched Friday on Netflix."I never forgot how kind and generous he was to a young kid just starting out in Hollywood," Cranston wrote.His "Jackie Brown" co-star Samuel L. Jackson tweeted that Forster was "truly a class act/Actor!!"A native of Rochester, New York, Forster quite literally stumbled into acting when in college, intending to be a lawyer, he followed a fellow female student he was trying to talk to into an auditorium where "Bye Bye Birdie" auditions were being held. He would be cast in that show, that fellow student would become his wife with whom he had three daughters, and it would start him on a new trajectory as an actor.A fortuitous role in the 1965 Broadway production "Mrs. Dally Has a Lover" put him on the radar of Darryl Zanuck, who signed him to a studio contract. He would soon make his film debut in the 1967 John Huston film "Reflections in a Golden Eye," which starred Marlon Brando and Elizabeth Taylor.Forster would go on to star in Haskell Wexler's documentary-style Chicago classic "Medium Cool" and the detective television series "Banyon." It was an early high point that he would later say was the beginning of a "27-year slump."He worked consistently throughout the 1970s and 1980s in mostly forgettable B-movies — ultimately appearing in over 100 films, many out of necessity."I had four kids, I took any job I could get," he said in an interview with the Chicago Tribune last year. "Every time it reached a lower level I thought I could tolerate, it dropped some more, and then some more. Near the end, I had no agent, no manager, no lawyer, no nothing. I was taking whatever fell through the cracks."It was Quentin Tarantino's 1997 film "Jackie Brown" that put him back on the map. Tarantino created the role of Max Cherry with Forster in mind — the actor had unsuccessfully auditioned for a part in "Reservoir Dogs," but the director promised not to forget him.In an interview with Fandor last year, Forster recalled that when presented with the script for "Jackie Brown," he told Tarantino, "I'm sure they're not going to let you hire me."Tarantino replied: "I hire anybody I want.""And that's when I realized I was going to get another shot at a career," Forster said. "He gave me a career back and the last 14 years have been fabulous."The performance opposite Pam Grier became one of the more heartwarming Hollywood comeback stories, earning him his first and only Academy Award nomination. He ultimately lost the golden statuette to Robin Williams, who won that year for "Good Will Hunting."After "Jackie Brown," he worked consistently and at a decidedly higher level than during the "slump," appearing in films like David Lynch's "Mulholland Drive," ''Me, Myself and Irene," ''The Descendants," ''Olympus Has Fallen," and "What They Had," and in television shows like "Breaking Bad" and the "Twin Peaks" revival. He said he loved trying out comedy as Tim Allen's father in "Last Man Standing."He'll also appear later this year in the Steven Spielberg-produced Apple+ series "Amazing Stories."Even in his down days, Forster always considered himself lucky."You learn to take whatever jobs there are and make the best you can out of whatever you've got. And anyone in any walk of life, if they can figure that out, has a lot better finish than those who cannot stand to take a picture that doesn't pay you as much or isn't as good as the last one," he told IndieWire in 2011. "Attitude is everything."Forster is survived by his four children, four grandchildren and Grayson, his partner of 16 years. 4241

LOS ANGELES (CNS) - Los Angeles County will once again prohibit dining at restaurants and bars beginning Wednesday, as the recent spike in COVID- 19 has brought the five-day average of new cases to more than 4,000, health officials said Sunday.To reduce the possibility for crowding and the potential for exposures in settings where people are not wearing their face coverings, the county's Health Officer Order will be modified so that restaurants, breweries, wineries and bars will only be able to offer take-out, drive thru, and delivery services.The order will apply for a minimum of three weeks.Officials warned of the possibility of such measures last week, as new cases and hospitalizations continued to surge in Los Angeles County and statewide. They follow a statewide "soft curfew" that went into effect Saturday prohibiting all "nonessential work, movement and gatherings" between 10 p.m. and 5 a.m., continuing until the morning of Dec. 21.On Sunday, the Los Angeles County Department of Public Health reported 2,718 new cases of COVID-19 and nine additional deaths, bringing the county's totals to 364,520 cases and 7,438 fatalities. The previous three days had each seen more than 4,000 cases reported, including a single-day record of 5,031 cases on Thursday.If the five-day average of cases grows to 4,500 or more or hospitalizations are more than 2,000 per day, a Targeted Safer at Home Order will be issued for three weeks, the health department said. That order would offer additional restrictions while allowing essential and emergency workers and those securing essential services to leave their homes.The number of county residents hospitalized with the virus increased from 1,391 Saturday to 1,401, with 26% in intensive care. That's more than double the daily number in the beginning of October, when it was under 700.The department reminded everyone to stay home as much as possible for the next two to three weeks to change the trajectory of surging cases and save lives, and repeated its advice that people not travel for the upcoming Thanksgiving holiday."As we modify our Thanksgiving holiday celebrations, we are reminded of the many families who will miss their loved ones who have passed away from COVID-19. We send wishes for healing and peace," County Health Director Barbara Ferrer said."The persistent high number of cases requires additional safety measures that limit mixing in settings where people are not wearing masks. We hope individuals continue to support restaurants, breweries and wineries by ordering for take-out or delivery. We also fervently hope every L.A. County resident supports all our businesses by following the Public Health directives that we know work to slow spread. Unfortunately, if our cases and hospitalizations continue to increase, we will need to issue further restrictions to protect our healthcare system and prevent more deaths."Other restrictions that took effect Friday were:-- indoor "nonessential" businesses such as retail stores, offices and personal care services will be limited to 25% occupancy;-- outdoor cardrooms, miniature golf sites, go-kart tracks and batting cages will be limited to 50% of maximum outdoor capacity;-- customers at personal-care businesses must make advance appointments, and no services that require customers to remove their face masks can be offered; and-- outdoor gatherings must be limited to no more than 15 people from a maximum of three households.The county previously issued guidance limiting gatherings to three households, but there was no numerical limit on attendees.Dr. Mark Ghaly, California's Health and Human Services secretary, said the state's order was not a hard curfew, indicating that people can still go outside of their homes, but they just shouldn't gather with others. He noted that he still plans to take his dog on its normal 11 p.m. walk.He said there is no definitive cause for the state's sudden surge in cases."There is no single culprit," Ghaly said. "It's a combination of factors. It's certainly the colder weather, more mixing, which comes with more opening. ... And of course greater travel. We've enjoyed some events over the last many weeks -- in my home county of Los Angeles, the Dodgers, the Lakers. We had Halloween. We just exited Veterans Day. We're looking forward to other future events and activities as we go into the winter."Asked about how restrictions will be enforced -- in light of Southern California sheriffs stating they won't be actively cracking down on health- order violations -- Ferrer said the county isn't relying on law enforcement, but rather hoping residents will take the urgency to heart."We really appreciate that the best enforcement is voluntary compliance," she said. "We've all done really well when we've set for ourselves a goal as a community and gotten behind it. I can't think of anybody at this point who's going to argue with the fact that we need to take some action to slow the spread, because this level of acceleration threatens our health care system."And that threatens care for every single person in this county -- for people who have a heart attack, for people who need emergency surgery, for people who need scheduled surgery, for people who are victims of car accidents or trauma."Ferrer also noted that the surge in cases is not just the result of increased testing. She said the county's rising rate of positive tests shows that the virus is spreading more rapidly. The county's seven-day average daily positivity rate among those tested for the virus was 3.9% on Nov. 1, but it rose to 5.1% by Nov. 8 and stood at 7.1%. as of Saturday. 5645

LOS ANGELES (KGTV) - A water main break created a sinkhole Friday, swallowing cars and flooding streets in South Los Angeles.The Los Angeles Department of Water and Power said a 24-inch cast iron water main broke around 5 a.m. near Towne Avenue and East 55th Street."We can't shut it down fast. On this shutoff, there's 12 valves involved. You just can't shut it down completely. You have to keep some water in the system. It's just a slow process," Eric Shavly from LADWP told KABC. "Whatever the cause, it could be corrosion, age - we don't know at this moment until we dig down and see the actual damage on the water main."A pickup truck that fell into the sinkhole also cracked a gas line, causing gas and water to be shut off to the area. 41 people were evacuated during the emergency, KABC reported.After four hours, crews gained control of the flow.The cause of the water main break was unclear. 910

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