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SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438

SAN DIEGO (KGTV) - At least two people suffered major burns in a boat fire off the coast of San Diego late Saturday night, according to Coast Guard officials.Two patients were critically injured and were flown from the boat by helicopter and have been transported to the hospital. The total number of patients at this time is unknown. The rest are expected to be brought to the shore by boat. The circumstances of the fire and the type of boat are unclear at this time.This is a breaking news story. 10News will update as details become available. 575

SAN DIEGO (KGTV) — As the coronavirus pandemic has left many San Diegans in need.From hospitals to food banks to neighbors, there are plenty of ways to lend a hand.HOW TO HELPHospitals: Many local hospitals are reeling from the coronavirus pandemic, mainly with a lack of personal protection equipment. One way to support hospitals is to donate gear. Many San Diego hospitals are accepting donations for masks, gloves, eye wear, hand sanitizer, food, money, and more to support the health care industry at this time. LinkMany have also started making masks for health care workers. To help contribute, find out more.Blood donations are also in critical need. To donate blood, visit the Red Cross San Diego or San Diego Blood Blank.Seniors: There are a number of ways to help out local seniors who are under self-isolation during the coronavirus pandemic. One of the easiest ways is logging on to NextDoor and connecting with neighbors to talk or help out if they need a hand. LinkIn San Diego, locals can also help out Serving Seniors, a non-profit that delivers meals to low-income seniors, by making a dontion. LinkFood: Local food banks are also in need of support — food, money, and volunteers — to response to needy San Diegans during the COVID-19 pandemic. To make a donation to the San Diego Food Bank, click here.Restaurants: Local restaurants are some of the hardest hit businesses during the coronavirus pandemic. A simple way to help them out is to continue supporting them. The #TakeOutChallenge supports the campaign to continue eating at local establishments. LinkAs part of 10News' We're Open San Diego initiative, you can search for businesses that are remaining open and continue lending your support during this tough time. LinkSmall businesses/Nonprofits: The San Diego Foundation has set up a Community Response Fund to help local nonprofits, who can in turn support small businesses and individuals affected by the coronavirus. Individuals, businesses, and foundations can make monetary contributions to support the fund. To make a contribution, click here. 2086

SAN DIEGO (KGTV) – Any other year, Sonia Highbaugh and her family would be spending Christmas gathered at her sister’s house, but in true 2020 fashion, things look a little different this holiday.“I was sad this year not being able to spend the holidays with my extended family and everyone, but we make those hard decisions for the betterment of everybody,” said Highbaugh. “We actually stayed home, it’s just my immediate family, my boyfriend, and our two boys. We made videos of them opening their gifts so we can share with family so we can feel like we were together.”Highbaugh works for the Chicano Federation and says through training with the San Diego Latino Health Coalition; she received pointers on how she should be spending the holiday this year.“With the pandemic, we wanted to be safe. I’m also expecting, so it’s very important for me to stay safe,” she said.Registered Nurse Francisco Garcia can relate.“It’s just us three,” said Garcia.While breaking traditions can be challenging, Garcia, his wife, and daughter also decided to spend Christmas at home together.“Being a Latino, my family chooses to get together every year for Christmas and have food and presents. Just having everyone together is what we take pride in, and so it’s very different that we’re not around each other this year,” he said.Working as a registered nurse, Garcia knows all too well the potential consequences of large gatherings during the pandemic, especially after the surge in COVID-19 cases after Thanksgiving celebrations.“Seeing an influx of patients and the number of patients we’re seeing with COVID as the year went on was a big challenge,” he said.Health officials across the nation, including here in San Diego County, have urged people to stay home, avoid traveling and large gatherings, despite that some continue to ignore the guidance.According to the Transportation Security Administration (TSA), 846,520 people in the United States were screened at TSA checkpoints on Christmas Eve alone, and millions more were screened since last Friday.Still, many families are playing safe and having a great time doing so.“It has been fantastic; I think the biggest challenge we’ve had is not burning the Christmas dinner,” said Garcia.“We have to trust our community. Hopefully other people are being safe so we can be safe,” said Highbaugh. 2351

SAN DIEGO (KGTV) - Country legend Clint Black is moving beyond Nashville stardom with his first-ever musical, now playing at San Diego’s Old Globe Theater. ‘Looking for Christmas’ is about Staff Sergeant Mike Randolf, who returns from deployment to Afghanistan to be with his family for the holiday."Mike Randolf is making it home just in time for Christmas but he's not really quite home. And through his daughter and her excitement over Christmas, understanding how it works, and then ultimately why it works and why we do it is one of the things that propels Mike forward,” Black told 10News.Clint Black created the idea from his 1995 holiday album and wrote the musical with playwright James Sasser."It was a real odyssey for me to try to find the true meaning of Christmas and it's what we're trying very hard to get across in the play."Randolf struggles to find the joy of the season with the help of his family."For me, the true meaning behind Christmas as I discovered it through writing the album was really the message to look around to others and what they need. It's fun to give people the things they want, but it's important to give people the things they need."‘Looking for Christmas’ runs through Dec. 31 at The Old Globe. For more information, click here. 1280

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