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The United Kingdom says it will be the first to conduct COVID-19 vaccine human challenge trials.It's different than other vaccine studies. People will be deliberately infected with the virus, which speeds up the research process.Pending approval, the process will start in January at a London hospital. It will require about 90 healthy young adults between the ages of 18 and 30.The group 1 Day Sooner has recruited from all over the world, including 3,000 Britons.“If the vaccine works, then ideally, people don't get infected and if people do, then they will be closely monitored and treated, but because these are young and healthy people taking part in the trial, I think, researchers feel comfortable doing so because the risks of death are on par with something like kidney donation for people who are young and healthy,” said Abie Rohrig with 1 Day Sooner.Before researchers test the vaccine, they'll do a characterization study. That's where volunteers are infected by getting a vaccine to determine the right amount of virus to give during the trial.Because of the risk, 1 Day Sooner is advocating for the entire process to be made public.Results could come in May. Even though that's likely after other COVID-19 vaccines are licensed, it's still important because we need billions of doses and because of the unique data human challenge trials provide.“Researchers can understand how the virus works in the human body. They can understand the biological markers of immunity. In fact, much of our understanding of other types of coronaviruses come from challenge studies that were conducted in the 1960s in Britain,” said Rohrig.Human challenge volunteers are paid and monitored for at least a year after. 1722

The U.S. has carried out the first federal execution in nearly two decades, putting to death a man who was convicted of killing an Arkansas family in the 1990s in a plot to build a whites-only nation in the Pacific Northwest. Forty-seven-year-old Daniel Lewis Lee, of Yukon, Oklahoma, died Tuesday after receiving a lethal injection at the federal prison in Terre Haute, Indiana. Lee said before his execution that he was innocent. “I didn’t do it,” Lee said just before he was executed. “I’ve made a lot of mistakes in my life, but I’m not a murderer. ... You’re killing an innocent man.” 597

The Rev. Pat Conroy, the chaplain at the US House of Representatives, has rescinded his resignation in a letter, obtained by CNN, following a week's worth of lawmakers from both parties questioning House Speaker Paul Ryan's request that Conroy step down."At this time, and upon advice of counsel, I herby retract and rescind said resignation for the reasons that follow," Conroy writes in the letter dated Thursday and addressed to Ryan.Conroy, a Jesuit priest, resigned April 15 after he spent nearly seven years praying at the outset of House sessions. He wrote two versions of his resignation letter, which were also obtained by CNN from a congressional source. In the first version, he wrote that Ryan, who is Catholic, should consult with his chief of staff on a resignation date, but the second version stated his last day would be May 24. 853

The Tuesday after Thanksgiving may be known as Travel Deal Tuesday, a day offering deals on airfare. But Cyber Monday is the day to book your dream vacation.  If you’re looking to take a family vacation, you may want to look at Universal Studios and Universal Island Treasure in Orlando.On undercovertourist.com, you can get two-day park tickets, plus two extra days free, if you buy today. That’s a total of 3 for four people for four full days. If you want another option for warm weather, you could travel to Miami and take an all-inclusive three-day Royal Caribbean cruise to the Bahamas. If you buy one full-price ticket, you’ll get your second one 60 percent off. The third and fourth ticket will be 30 percent off!The total cost for a family of four will cost 5. The deal can be found on americandiscountcruises.com.Have you always wanted to go to the Grand Canyon? If you take the Grand Canyon train tour, you can save 50 percent on your once in a lifetime trip.Thetrain.com is offering a three-day, two-night stay in Williams, Arizona for 5 for two people. That's a 0 savings.If the west coast is more your style, a family of four can head to LEGO Land for a crazy good deal. LEGO is offering 30 percent off rooms and 50 off two-day LEGO Land tickets on their website. You can get all of that for 1 per person for a two-day stay. 1381

The Senate Intelligence Committee voted 10-5 closed doors Wednesday to advance Gina Haspel's nomination as President Donald Trump's CIA director pick, advancing the nominee to a full floor vote where she looks all but assured to win Senate confirmation.Two of the committee's seven Democrats have said they are supporting Haspel, including Virginia's Sen. Mark Warner, the top Democrat on the panel. Haspel currently has more than enough support to win confirmation, as Warner was one of three Democrats to announce Tuesday that they were voting for her, bringing the total to five.   602