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SAN DIEGO (KGTV) - Cal Trans closed down a section of southbound I-5 Thursday night.The closer started at 9:30 p.m. from the I-805 split to La Jolla Village Drive.The closure is expected to last until 5 a.m. Friday.Crews shut down the section of freeway due to necessary work on the construction of a trolley overpass over the interstate. Teams needed to bring heavy equipment onto the freeway to pour concrete onto the structure.Overnight and early morning commuters that take I-5 SB is being rerouted to I-805 SB and will need to use Highway 52 or I-8 to cut over.Crews say they will need to do follow up work within on the overpass in the next few weeks, so drivers should expect the same closure again. 716

SAN DIEGO (KGTV) -- California health officials released new guidelines for indoor and outdoor youth sports, whether it is school-related, community sponsored, or club sports.The new guidance from the state’s Department of Public Health also applies to recreational adult sports.According to the state, inter-team competitions will not be allowed until Jan. 25, 2021, at the earliest. State officials will revisit this plan during the first week of January to see if any changes need to be made.Players and teams are allowed to practice, but health and safety measures -- such as social distancing -- must be in place.In the new guidelines, sports are categorized by indoor or outdoor, and then they are classified under three categories: low-contact, moderate-contact, and high-contact. The sports are then grouped based on risk tier.For San Diego County, which is in the state’s purple tier as of Dec. 15, only outdoor low-contact sports -- which includes golf, tennis, and swimming -- are allowed to compete.Once the county reaches the red tier, sports like baseball, softball, and cheerleading will be able to compete.Sports such as basketball, football, soccer, and volleyball would not be allowed to compete until San Diego County is in the state’s orange tier.The state’s new guidance comes months after children, parents, and coaches held rallies and voiced their frustrations about not being able to play.Because of the state’s rules, many teams -- specifically baseball and soccer -- have traveled to states like Arizona to play competitively because of less strict rules.Under California’s new guidance, teams can only compete against teams from the same county, and they cannot compete outside of the state.Click here to view the state's complete guidelines 1777

SAN DIEGO (KGTV) — As the coronavirus pandemic has left many San Diegans in need.From hospitals to food banks to neighbors, there are plenty of ways to lend a hand.HOW TO HELPHospitals: Many local hospitals are reeling from the coronavirus pandemic, mainly with a lack of personal protection equipment. One way to support hospitals is to donate gear. Many San Diego hospitals are accepting donations for masks, gloves, eye wear, hand sanitizer, food, money, and more to support the health care industry at this time. LinkMany have also started making masks for health care workers. To help contribute, find out more.Blood donations are also in critical need. To donate blood, visit the Red Cross San Diego or San Diego Blood Blank.Seniors: There are a number of ways to help out local seniors who are under self-isolation during the coronavirus pandemic. One of the easiest ways is logging on to NextDoor and connecting with neighbors to talk or help out if they need a hand. LinkIn San Diego, locals can also help out Serving Seniors, a non-profit that delivers meals to low-income seniors, by making a dontion. LinkFood: Local food banks are also in need of support — food, money, and volunteers — to response to needy San Diegans during the COVID-19 pandemic. To make a donation to the San Diego Food Bank, click here.Restaurants: Local restaurants are some of the hardest hit businesses during the coronavirus pandemic. A simple way to help them out is to continue supporting them. The #TakeOutChallenge supports the campaign to continue eating at local establishments. LinkAs part of 10News' We're Open San Diego initiative, you can search for businesses that are remaining open and continue lending your support during this tough time. LinkSmall businesses/Nonprofits: The San Diego Foundation has set up a Community Response Fund to help local nonprofits, who can in turn support small businesses and individuals affected by the coronavirus. Individuals, businesses, and foundations can make monetary contributions to support the fund. To make a contribution, click here. 2086

SAN DIEGO (KGTV) - Complaints about red-light runners are mounting at a busy intersection in Mira Mesa.Jacob Rogers, 12, says his dad was recently driving him through the intersection, when this happened.   219

SAN DIEGO (KGTV) - Anyone touched by Alzheimer's knows how painful the disease is. "It's affected my family. It's affected most families. It's such a prevalent disease. As people get older, it becomes quite likely this will become an issue," said Paul Aisen, director of USC's Alzheimer's Therapeutic Research Clinic (ACTC).Aisen's team began their research in San Diego many years ago and teamed up with USC about four years ago. He's spent over 30 years trying to solve Alzheimer's mysteries and is leading the upcoming clinical trial.Aisen says the large-scale study is the culmination of decades of work from scientists worldwide."Our focus lately has been trying to alter the disease, prevent it, or significantly slow its progression. How should we do that? We think attacking amyloid early is the most promising approach," said Aisen. Researchers believe sticky amyloid deposits, which form on the brain later in life, start the Alzheimer's process. Aging, genetics, and lifestyle factors can all contribute to amyloid build-up.The worldwide clinical trial aims to target amyloid. A drug called BAN2401 will be delivered intravenously, designed to bind to the sticky amyloid. The binding neutralizes beta amyloid and helps "tag" it, so the immune system can recognize it and clear it from the brain. A previous phase 2 study showed that BAN2401 removes brain amyloid and possibly slows cognitive decline.They're seeking participants over 50 who are not yet showing symptoms of Alzheimer's but do have elevated amounts of amyloid on their brain. Researchers can determine that through a PET scan or spinal tap. "We think that the most promising approach of all is to take a vigorous attack on amyloid while the brain is still functioning normally. And we can see amyloid in people many years before they develop the symptoms of Alzheimer's."Investigators hope that by treating a patient with BAN2401 very early in the disease, before symptoms occur, it will significantly slow disease progression. "If we're successful, it will have a huge impact on human health," said Aisen. There will be 100 sites worldwide for the study, including major cities like San Diego and Los Angeles. Study participants will receive treatment for four years, given either the drug or a placebo. Results are expected in seven years, Aisen says. If you or a loved one wants to participate, learn more here.Screening will officially begin in May. 2438

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