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SAN DIEGO (KGTV) -- As the weather across San Diego County warms, rattlesnakes are out if full force.Rattlesnakes live throughout Southern California and live in the deserts as well as along the coast, according to the California Department of Fish and Wildlife. The department says most bites happen from April to October when the snakes and people are most active outdoors. RELATED: Deadly backyard encounter could point to dangerous snake season“Snakes really get an unfair bad rap, when they actually play an important role in California’s ecosystems,” said CDFW’s Keep Me Wild program coordinator Lesa Johnston. The potential of running into a rattlesnake shouldn’t deter anyone from enjoying the great outdoors, the department adds. According to the California Poison Control System, the chances of being bitten are small when compared with the risk of other environmental injuries. RELATED: What to do if you or a pet are bitten by a rattlesnake“Like most wild animals, snakes prefer to keep to themselves and are not naturally aggressive. Taking the time to learn about safety precautions before going outdoors can make all the difference,” Johnston added. The department says rattlesnakes generally aren’t aggressive and will likely retreat if given room and not provoked or threatened. “Most bites occur when a rattlesnake is handled or accidentally brushed against by someone walking or climbing,” the department says on their website. If you are bitten by a rattlesnake, the department recommends the following: Stay calm but act quickly.Remove watches, rings, etc., which may constrict swelling.Transport the victim to the nearest medical facility.For more first aid information call the California Poison Control System at (800) 222-1222. 1761

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) - As a Hillcrest man showered in his apartment, an intruder was helping himself to a "priceless" pendant.The surveillance video that Ramon Castillo has seen countless times remains hard to watch."Scary and very disturbing," said Castillo.In late June on a Monday morning just before 9, Castillo was showering in his apartment on 3rd Avenue. What he didn't know know: he wasn't alone. When Castillo got out of the shower after 20 minutes, the screen door which had been locked was completely open. Surveillance video revealed why. In it, a man pauses at the door and somehow gets past the screen door, before quietly raiding the apartment. Among the items stolen were speakers and a safe from a bedroom closet. Inside the safe: cash, personal documents and jewelry, including a silver pendant containing the ashes of her mother. She passed away in 2015 from an accidental drug overdose."I can't replace that. It's the last thing of my mom and now I don't have anything," said Castillo.The thief who snatched it was in and out in about five minutes. He was seen driving off in a sedan. Castillo say the burglar had to have heard the shower running and went in anyways."He didn't think twice about it. I fear for the next person he goes after ... he might harm someone," said Castillo.If you do have information on the case, you're asked to call Crime Stoppers at 888-580-8477. 1399

SAN DIEGO (KGTV) -- As Gloria Rickerd flipped through the pages of her wedding album in her Mira Mesa home, she said the chemotherapy medications her husband takes has kept him alive longer than doctors anticipated.But like many Americans -- nearly one in eight, according to a recent Kaiser Family Foundation study -- she thinks the cost of those drugs is unreasonable."I walked into the pharmacy at UC San Diego, and they looked at me said that will be 0. It was like four or five pills," she said. "It’s like, ok so, this is what you want me to pay and if I can’t do that, I guess he’ll just die?"On Friday, Gov. Gavin Newsom laid out several healthcare proposals designed to lower prescription drug costs, including a plan to make California the first state to make its own generic prescription drugs.The Democratic governor wants the nation’s most populous state to contract with generic drug companies to make medications on its behalf so it could sell them to its nearly 40 million residents. The goal is to lower prices by increasing competition in the generic drug market, Newsom said.The state is still determining which drugs it will manufacture, but Newsom hinted that insulin was "top of mind."His proposal also would create a single market for drug pricing in California, with companies having to bid to sell their medicine at a uniform price. One expert said that piece would have the bigger impact."Other countries control or negotiate the price of drugs, and if there is one state that could do it, it’s California, which is the size of a country,” said Larry Levitt, executive vice president of health policy for the Kaiser Family Foundation. “A drug company could walk away from Rhode Island. It’s much harder to walk away from California.”Lawmakers would have to approve the proposals before they could become law. A legislative leader in charge of reviewing the plan gave a tentative endorsement Thursday.“If Costco can have a Kirkland brand, why can’t California have our own generic brand?” said Democratic Assemblyman Joaquin Arambula, an emergency room doctor from Fresno who chairs the House Budget Subcommittee on Health and Human Services. “I really do think there is quite a bit of merit in having us produce the medications."Priscilla VanderVeer, vice president of the Pharmaceutical Research and Manufacturers of America, which represents brand-name drug companies, said she’s waiting for more details from Newsom before commenting.A representative from the Association for Accessible Medicines, which represents generic drug manufacturers, did not respond to a request for comment."I have more questions than I do have answers," said Tatiana Fassieux of California Health Advocates. "It is a very good first step but I would not see any end result coming up soon because it is going to take time."The drug plan is part of Newsom’s budget proposal, which he presented to lawmakers Friday.Newsom’s office did not say how much the drug proposal would cost, prompting criticism from some Republican lawmakers who said the state should not compete with private companies.“When the state runs it, it costs more money,” said Republican Assemblyman Devon Mathis, who’s also on the health subcommittee. “The money is coming out of families’ pockets paying all those crazy taxes.”California law requires drug companies to report any price increases to the state. Generic drugs saw a three-year median increase of 37.6%, according to a report from the Office of Statewide Health Planning and Development. That analysis was based on the list prices of the drugs and did not include discounts or rebates.But the report doesn’t include generic drugs that decreased in price because companies are not required to report that. Nationally, generic drug prices have been decreasing overall, according to a report that AARP produced with the University of Minnesota.Supporters say California’s generic drug label could help lower the cost of a common drug that has steadily increased in price — insulin for diabetes patients. Three drug companies control most of the market for insulin.“Consumers would directly benefit if California contracted on its own to manufacture much-needed generic medications like insulin — a drug that has been around for a century yet the price has gone up over tenfold in the last few decades,” said Anthony Wright, executive director of Health Access California.Jon Roth, CEO of the California Pharmacists Association, said the state might be surprised, however, at how much it ends up charging for its own generic drugs because of factors beyond its control, including raw material shortages and disruptions in the supply chain.“There are other factors in the actual manufacturing that the state may not be able to escape,” he said.While most Americans get generic prescriptions, they only account for a small part of the total drug spending in the U.S. That’s because unlike the name-brand drug market, generics are very competitive, said Jeff Joyce, chairman of the Department of Pharmaceutical and Health Economics at USC’s School of Pharmacy. "What he is proposing to do would help in specific cases, but it’s not a panacea by any means,” Joyce said.The proposal is another step in Newsom’s effort to overhaul California’s prescription drug market. Last year, in one of his first acts in office, Newsom ordered the state to take over the Medicaid program’s prescription drug benefits, which affects 13 million people. 5477

SAN DIEGO (KGTV) — Border officials seized more than 10 tons of marijuana hidden behind a cargo shipment at the Otay Mesa Port of Entry this week.At about 9 a.m. Monday, an agent with U.S. Customs and Border Protection was inspecting a truck with a manifested shipment of "plastic garment hangers." The vehicle was referred to a secondary inspection where an x-ray machines would continue the inspection.During the secondary inspection, officers detected an anomaly which prompted another examination this time with a canine. The canine alerted officers to the vehicle's trailer, where a search led to 858 plastic-wrapped packages stacked to the trailer's ceiling behind cargo.RELATED:Border Patrol arrests teen with toy car at U.S.-Mexico borderMother tries to smuggle meth with young children in SUV, Border Patrol saysBorder officials say the wall is working, drug smuggling shifting to the seaCBP officers said the packages tested positive for marijuana. There were more than 10 tons of the narcotics, worth about .4 million.The driver of the truck, a 47-year-old Mexican citizen, was turned over to Homeland Security and his B1/B2 visa was canceled, CBP said. The truck, trailer, shipment, and narcotics were seized by CBP.“The ability of CBP officers to interdict contraband at the port of entry is a perfect example of CBP’s efforts to secure our border,” Joseph Misenhelter, Officer in Charge at the Otay Mesa Port of Entry, said. “CBP officers prevented over 10 tons of marijuana from entering our community.” 1529