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2025-05-30 23:10:46
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  宜宾割双眼皮开外眼角   

WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."

  宜宾割双眼皮开外眼角   

SAN FRANCISCO, Dec. 8 (Xinhua) -- Twitter on Thursday started to roll out a major redesign of its interface in hopes of simplifying users' experience, as well as new brand pages to strengthen its relationship with advertisers.During a press conference at its new headquarters in San Francisco, Twitter Chief Executive Officer Dick Costolo and co- founder Jack Dorsey unveiled a whole new look of the social networking and microblogging service.According to an introduction video, the new homepage features profile on the left and the timeline on the right, which are flipped from the current positions and take less space than they used to.Three new buttons were also introduced as "Home," "Connect" and "Discover." "Connect" shows users who has mentioned them and suggests some accounts they might want to follow. "When you use Discover, you'll see results reflecting your interests -- based on your current location, what you follow and what's happening in the world," said Twitter.The overhauled interface is only available to a small group of users at first and will be rolled out to all users over the coming months. It will also remain consistent across Twitter's official mobile apps. Twitter has launched a page fly.twitter.com to explain all the changes.Along with the introduction of the redesign, Twitter also announced new brand pages on its platform. A total of 21 brand partners will be included in the initial launch, such as American Express, Best Buy, Bing, Coca-Cola, HP, Disney and Nike.Analysts said Twitter has ambitions to compete with similar brand pages from Facebook and Google+. According to eMarketer, Twitter's global advertising revenue is expected to reach 139.5 million U.S. dollars this year and approach 400 million dollars in 2013.

  宜宾割双眼皮开外眼角   

NEW YORK, Oct. 3 (Xinhua) -- For the 34-year-old Alexis Steinman, Oct. 3 would have been a great day, because her father Ralph Steinman was announced winner of the 2011 Nobel Prize in Physiology or Medicine.But as she talked to Xinhua at the Rockefeller University where his father worked, she said the day was rather "bittersweet"."This is the moment, but my Dad was not here," said Alexis, trying to hold her tears.The Canadian-born cell biologist Ralph Steinman died of pancreatic cancer on Friday at the age of 68, three days before he was announced the joint winner along with Prof. Bruce Beutler and Prof. Jules Hoffman for the Nobel Prize in Physiology or Medicine."We even talked about the Nobel Prize days before his death," Alexis added."We were like 'OK Dad, I know things aren't going well but the Nobel, they are going to announce it next Monday'. And he was like 'I know I have got to hold out for that. They don't give it to you if you have passed away,'" she said."It's really impossible to describe how our family is feeling right now. We're devastated to have lost Ralph,"Steinman' s son Adam Steinman told reporters at the press conference at Rockefeller University. "We're so incredibly proud of Dad for receiving this wonderful honor ... We know he will live on through his scientific contributions," he said.Rockefeller University president Marc Tessier-Lavigne told reporters during Monday's press conference that the university only heard of Steinman's death from the family about half an hour after news of the Nobel prize came out from Sweden."We are all deeply saddened by his death, " said Tessier- Lavigne , adding that Steinman had been treating himself with a groundbreaking therapy based on his research into the body's immune system.He said Steinman's research has laid the foundation for numerous discoveries in the critically important field of immunology, and it has led to innovative new approaches in how people treat cancer, infectious diseases and disorders of the immune system.Steinman's first student and close colleague Michel Nussenzweig told the press conference packed with reporters, students and professors that "one of the interesting things about Ralph and his discovery is that no one believes it for a really long time.""What was amazing about Ralph was that he just knew that, even though nobody else believed it, this was really important, and he persisted, and finally after a very long time, everyone just found out it was true," Nussenzweig said."Ralph worked until last week. His dream was to use his discovery to make vaccines and it is a dream that is pretty close, and we are all continuing to work to make that come true," he added.The Nobel Foundation made a statement after learning Steinman's death, saying that the decision to award the prize to the Canadian scientist would remain unchanged despite his death, and the prize money will be transferred to his estate.

  

HOUSTON, Dec. 13 (Xinhua) -- NASA Johnson Space Center on Tuesday formed a partnership with Texas's largest tech incubator and accelerator, the Houston Technology Center (HTC), to help reach its goals of increasing private and public collaboration.The strategic partnership is aimed at expanding HTC's mission of accelerating the growth of emerging technology companies in the Houston region to support NASA's goals of increasing private and public cooperation, the parties said in news release."We are excited to partner with NASA Johnson Space Center in an effort to foster entrepreneurial opportunities to the transitioning workforce in the Bay Area," said Walter Ulrich, CEO of Houston Technology Center."The combination of NASA's incredible technologies and HTC's powerful entrepreneurial resources presents the potential for immense economic development," he said.HTC is committed to growing a sustainable entrepreneurial network that will benefit the surrounding the space center for years to come including its future missions beyond low earth orbit. HTC will seed the future workforce through its close ties with the major universities and with science, technology, engineering, math programs and objectives, according to the news release.NASA and the Houston Technology Center began their partnership earlier this year when they originally formed plans to open an office to help former contractors near the Johnson Space Center.With the signing of the Space Act Agreement on Tuesday, the two sides move forward with retraining contractors and helping them get new jobs in the Houston area.An estimated 4,000 people are expected to lose their jobs when the space shuttle program is completed.

  

ADDIS ABABA, Nov. 2 (Xinhua) -- Ethiopia will host the 13th World Congress on Public Health (WCPH) in April 2012, the Ethiopian Public Health Association (EPHA) said on Wednesday.The meeting will be held on April 23-27 under the theme: "Moving towards Global Health Equity- Opportunities and Treats".Speaking on the 22nd annual meeting of EPHA held here on Wednesday EPHA President Tewabech Bishaw said about 3,000 participants, including public health students from all over the world are expected to take part in the meeting.He said that preparations are well underway to successfully conduct the meeting.

来源:资阳报

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