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SAN DIEGO (KGTV) — In the race for a coronavirus vaccine, scientists often say we need more than one winner.That’s in part because different vaccines use different strategies to provoke the immune system, and each strategy has different strengths.Take the inactivated virus vaccine, an approach currently used in the vaccine against the poliovirus. In this approach, scientists take a live virus, kill it with chemicals or heat, and then introduce that viral corpse into a person.There are three groups in the final phase of human trials using inactivated coronavirus, primarily in China, according to a tracker from the Milken Institute.“The immune system can tell the difference between something that's a real threat and something that's not a threat, and so if you get injected with a dead virus your immune system has the tendency to not pay a lot of attention to that,” said Dr. Shane Crotty of the La Jolla Institute for Immunology.The downside of the inactivated virus approach is that it only elicits two out of the three of the parts of the immune system, Dr. Crotty said. It’s capable of producing antibodies and helper T-cells, but not killer T-cells.The modern take on the inactivated virus approach is called a viral vector vaccine.In this strategy, scientists combine elements of the coronavirus with a common cold virus called an adenovirus that won’t make you sick. Since the virus is alive, it can elicit all three kinds of immune responses, Dr. Crotty said.“There are no licensed vaccines right now that use that strategy, but there are all kinds of vaccine trials that have been done around the world with those types [of vaccines] showing that they're straightforward to manufacture. They're very safe,” he said.The University of Oxford is testing a viral vector vaccine for COVID-19 in a Phase 3 clinical trial.Then there are subunit vaccines. These include just a section -- or subunit -- of the virus’ protein.UC San Diego is working on a coronavirus candidate vaccine using this approach.There are subunit vaccines currently on the market for tetanus and other viruses.“Working with proteins is more challenging, just from a laboratory and manufacturing perspective,” Dr. Crotty said.Enter the next phase of vaccine development. Instead of using the virus itself or fragments of it, Inovio Pharmaceuticals is working on a vaccine strategy using just the virus’ genetic information.DNA-based vaccines simply introduce a genetically engineered blueprint of the virus into a person, and the cells do the rest.“Some people get confused about this. They think it’s a genetic vaccine that changes their DNA and becomes part of them, and that’s definitely not the case.” Dr. Crotty said. “They don’t become part of you. Your body chews them up.”Researchers have been working on DNA-based vaccines for about 20 years, Crotty said, but none are currently licensed for use.San Diego-based Arcturus Therapeutics is using an RNA-based approach, along with other companies like Pfizer and Moderna that have entered Phase 3 trials.Messenger RNA reads the DNA instructions and helps translate them into proteins.Dr. Crotty said the DNA and RNA approaches have similar drawbacks and benefits: they’ve never been approved for us, but both can be developed rapidly because they don’t require access to the physical virus.Around the world, there are more than 200 coronavirus vaccines currently in development, according to the Milken Institute. 3459

SAN DIEGO (KGTV) - Law enforcement agencies across San Diego County must comply with a new law designed to increase transparency of police misconduct.Senate Bill 1421 requires departments to release records of officer-involved shootings and major uses of force, officer dishonesty and confirmed cases of sexual assault to the public.Earlier this year several police associations in San Diego County sued to block the release of records, arguing Senate Bill 1421 doesn’t contain any express provision or language requiring retro-activity or any clear indication that the legislature intended the statue to operate retroactively.They claimed the bill eliminates the longstanding statutory confidentiality of specified peace officer or custodial officer personnel records.In March a judge ruled the bill applies retroactively to all personnel records of peace officers not only now but before January 1, 2019.The Judge ruled no records could be released before March 29 giving the unions time to appeal if they want. It does not appear any have appealed.Some agencies tell 10News they plan to start releasing records this week.10News is still waiting to hear from other local agencies about when they are planning to release records. 1238

SAN DIEGO (KGTV) — Lunar New Year kicks off in San Diego and thousands prepare to celebrate a civil rights icon.Lunar New Year celebrations at SDCCU Stadium and SeaWorld are running through the weekend in celebration of the Year of the Rat. Locals can check out all the delicious Asian-inspired foods and traditional dancing and performances marking the occasion.This weekend will also celebrate Martin Luther King Jr. as floats, marching bands, and more parade down Harbor Dr. to pay tribute to Dr. King and his work during the civil rights movement. 10News live be live streaming the parade on 10News.com, our 10News mobile app, on Facebook, and on your television streaming device (Roku, Apple TV, Amazon Fire).MORE: Don't see anything you like? Check out our event calendar for even more local eventsOr, visit with the camels, sheep, birds, and more in Ramona, where Oasis Camel Dairy Farm is holding an open house event with tons of activities for families. Borrego Springs also packs a weekend of cinematic fun in the desert with their annual film festival. Here's a look at all the fun this weekend:THURSDAYBorrego Springs Film FestivalWhere: Borrego Springs Performing Arts Center; Cost: - 5(Thursday - Sunday) Enjoy the works of young and seasoned filmmakers at the Borrego Springs Film Festival, filled with opportunities to network with filmmakers, take part in Q&A sessions, listen to panel discussions, and check out a variety of wonderful films.Winter Paradice: Skate, Create and CelebrateWhere: Fleet Science Center; Cost: -(Thursday - Sunday) The holiday spirit is still strong at The Fleet Science Center for a special winter exhibit. Take off your flip flops and get skating on a synthetic ice rink, make your own ornament, or create your own ice cream as a holiday treat at the Skate, Create, Celebrate exhibit. Special pricing and hours also invite guests out for late-night skating and cocktails.FRIDAYSan Diego Lunar New Year FestivalWhere: SDCCU Stadium; Cost: - (Friday - Sunday) SDCCU Stadium hosts the San Diego Lunar New Year Festival, bringing dragon and lion dancing, firecrackers, games, a variety of local food vendors, and more for three days in celebration of Lunar New Year.Shen Yun 2020Where: California Center for the Performing Arts, Escondido; Cost: - 0(Friday - Sunday) The excitement of Shen Yun returns to San Diego, bringing a colorful and theatric display of traditional Chinese culture through five millennia. With stunning costumes, high-tech backdrops, and a unique blend of music and dance, Shen Yun immerses audiences into a multi-dimensional journey of classic Chinese dance. SATURDAYThe Oddities & Curiosities ExpoWhere: Del Mar Fairgrounds; Cost: Free-Explore the world of the strange and unusual at the Del Mar Fairgrounds at the San Diego Offities & Curiosities Expo. Guests can peruse jewelry made from bones, skulls, insects, original artwork, performances featuring human suspension, and more of the strange, weird, and unusual.Oasis Camel Dairy Open Farm eventWhere: Oasis Camel Dairy; Cost: - (Saturday - Sunday) Enjoy a weekend in Ramona visiting camels, sheep, donkeys, and more at Oasis Camel Dairy. The farm's Open Farm event invites the public in for camel rides, pet feeding, a game area, bird and animal shows, and more farm exhibits.Bloom Yoga fundraiserWhere: Bloom Yoga, El Cajon; Cost: VariesBloom Yoga is hosting a donation-based yoga class to help a Jamul 6-year-old boy who was involved in a car accident and is currently hospitalized. The yoga studio is hosting a class in hopes of raising money to help his mom with medical expenses.SeaWorld Lunar New YearWhere: SeaWorld San Diego; Cost: Starting at online(Thursday - Sunday) SeaWorld is hosting a month's worth of Lunar New Year celebrations featuring amazing acrobatics, dancing and cultural performances around the park, as well as interactive activities for families and, of course, some delicious Asian-inspired cuisine for Lunar New Year.SUNDAY40th annual Martin Luther King Jr. Day ParadeWhere: Harbor Drive; Cost: FreeThe 40th annual Martin Luther King Jr. Parade steps off on Jan. 19, bringing floats, high school bands and drill teams, colleges, churches, and many more to Harbor Drive to honor the work of Dr. King. The parade is free and begins at 2 p.m. in front of the County Administration building.San Diego Restaurant WeekWhere: Various locations; Cost: - San Diego Restaurant Week brings special pricing and delicious eats to hungry locals, with more than 180 restaurants taking part in the week-long event offering two-course lunch price points from to , and three-course dinner options from to .Carlsbad Marathon, Half Marathon, and 5KWhere: Marron Rd. and Monroe St.; Cost: - 9San Diego runners take off in the first of three races this year as part of the Triple Crown series with the Carlsbad Full or Half Marathon. Carlsbad's half marathon takes runners on 8 miles along the Pacific Ocean, Buena Vista Lagoon, and on Highway 101. The out-and-back course is described as "gently rolling" with no major elevation changes and mostly unobstructed views of the ocean. 5193

SAN DIEGO (KGTV) -- In February, we spoke to Jelynn Malone from Mostra Coffee after her coffee shop won best roaster in the U.S. by Roast Magazine. Since then, things for small businesses like hers have been touch and loyal customers including high school juniors, Siya and Anoushka, wanted to help."A lot of businesses were closing. We both brainstormed about how we could help local businesses who have helped us in the past," said Anoushka." So they created a campaign called Loving the Locals. "We started a GoFund Me page and reached out to friends and family who were able to donate. With that money, we were able to donate to Mostra Coffee."And when Malone was ready to meet her donors she said, "I'm looking for adults, they didn't give me their names or tell me how much and I see these two young high school girls and they're like 'Are you Jelynn?'" To describe Malone as surprised was an understatement. "Then they hand over this large check to me and it says a thousand dollars and I'm completely shocked. I'm emotional, touched," Malone described. Malone's no stranger to giving back. A portion of her profits goes to farmers in the Phillippines, where she sources a lot of her product from. When the pandemic began, she donated gratitude boxes to frontline workers. All of her efforts never went unnoticed, even by young customers. "They [Mostra Coffee] continue to give back to community even during these difficult times and we felt that quality was important to us and it's what we were going for. We shared similar values and they were a great fit for us," Siya said. Mostra Coffee is the first business Loving the Locals has donated to. They have a GoFund Me and all profits will go to another small business once their goal is met. 1760

SAN DIEGO (KGTV) - Looking for more space for your money? The Del Cerro and Torrey Highlands are the best San Diego neighborhoods for renters, according to HotPads.Analysts evaluated rental size and price per square foot. San Diego’s median rental size is 1,154 feet, and renters can expect to spend .32 per square foot of space.The median rental size in Torrey Highlands is 2,033 square feet, at .14 per square foot, HotPads reported. Del Cerro residents pay .77 per square foot, with a median rental size of 1,710 square feet. Rancho Pe?asquitos, Miramar Ranch North (Scripps Ranch), and the South Bay neighborhood of Ocean Crest are also in the top five communities with the most space for the money.RELATED: Report: San Diego seeing housing price cutsLas Vegas, a top destination for San Diegans who choose to leave the city, has some of the largest rentals and the most affordable rents. Raleigh, North Carolina, is also a good value, according to HotPads analysts.Denver and Boston have the smallest rentals for the money, averaging about 1,050 square feet. By comparison, Los Angeles and San Francisco average at 1,200 square feet.Size matters, but not as much as price. A Zillow Group Consumer Housing Trends Report showed 82 percent of renters named affordability as a top concern, 42 percent said finding the right size rental was extremely or very important.RELATED: The 10 fastest-growing metro areas 1431

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