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As we're all focused on the current rollout of the COVID-19 vaccine, a technology known as thin-film freezing is getting a lot of attention. It's groundbreaking and could change the way we administer drugs or use medicine in general.You've probably heard about the need to keep the COVID-19 vaccine cold. It has to be so cold, in fact, that the shipment and transport are challenging. Well, what if that vaccine could be turned into powder?“What we’ve most recently been working on is the elimination of cold chain by storing as a powder, a dry powder where the drug is much more stable than if it was stored as a liquid or as a frozen liquid,” said co-inventor Dr. Robert Williams.Williams said it would eliminate the need for extreme cold storage and transport. The technology isn't new. He got a research grant and came up with it about 15 years ago.Williams, who is also a pharmacy professor at the University of Texas in Austin, said they were working on the technology and its multiple uses when the pandemic hit. And all of a sudden, they got a lot of attention.“We have published over 70 papers on the technology and using it for different products- it’s quite a mature process," Williams said. "We developed it because with other vaccines, the majority of the vaccine cost is in wastage because of this cold chain issue, so we published several key papers where we showed our thin-film freezing technology would protect vaccines - and you wouldn’t need cold chain storage.”Glenn Mattes, President, and CEO of TFF Pharmaceuticals added that the powders can be converted to topical preparations and they are currently working with the US Army to take some of the preparations and would then administer them directly through the eye.TFF is launching thin-film freezing into development through the FDA process. “I use the term ubiquitous because it is and disruptive because it is,” Mattes said. He added that they've explored their technology in the cannabinoid realm. But, as for the COVID vaccine, they're aiming for a second-generation usage.“To truly eradicate the pandemic, you have to have a global response," Mattes said. "The companies we’ve been speaking to certainly recognize the broad utilization of the technology but the application to the developing world, rural area, remote areas, where you can take a powder and inhale it or take the powder and reconstitute it has tremendous potential."Experts say it is only just the beginning as they launch their technology into a new world. 2511
As many people started decorating early, it's likely 2020 is a "boom" year for Christmas tree sales. Some even bought a "real" tree for the first time.In July, Bob Schaefer had a feeling it was going to be a big year for Christmas tree sales. The general manager of Oregon-based Noble Mountain Tree Farm says his company looks at the big holidays leading up to the Christmas season to get an idea of what the market will be like.“The next thing we watch is pumpkins - again, off the charts, early,” Schaefer said.Noble Mountain is a large tree producer, and it has been in the Christmas business since 1969. It now sells about half a million trees a year. Schaefer says it developed helicopter harvesting and can have your tree cut and shipped in 24 hours.“This year, we shipped to Dubai, Hong Kong, Canada, Mexico and of course the US,” Schaefer said.Christmas trees are a 10-year crop and once a farm has harvested those trees that are mature and ready, that's it for the tree.“Our sales were off the charts and we did sell out,” Schaefer said. “We’re wholesalers, we don’t sell to individual customers, but our wholesale sales were done by the first of October. Our trees were committed for sale."Schaefer said people started decorating the weekend after Halloween, leading to thriving initial sales.“If it turns out that COVID has people staying home and they have in their hearts the need for a lot of Christmas cheer, then we can provide that with a real tree,” Doug Hundley, spokesman for the National Christmas Tree Association, said.He said if you don't have your tree yet, don't worry. They won't sell out."We’ve never had a shortage. What we have now is a nice balanced, tight market between supply and demand,” Hundley said.It's no easy feat to predict the market, in fact, it's next to impossible, he said.“When we have a boom year like we may be having right now, we kind of suspected it, but we didn’t anticipate it and we can’t produce a real tree overnight,” Hundley said. “So, we have to provide what we have and hope it’ll work out.”He said if lots are empty, it's because the major tree weekends have passed.Ninety percent of people have already gotten their tree this year. Hundley says what's left will suffice for those who still need one. He hopes they all sell. If they don't, they're rendered useless.“The beauty of real trees over fake is we have a highly biodegradable product, it’s grown naturally, part of nature, benefits the environment supports the American economy and when we’re done, we can grind them so easily and chip them into mulch,” Hundley said. “They literally become soil in a couple of years, put back in the ground.”If you are purchasing a natural Christmas tree, experts recommend not adding additives. All your tree needs is plain water at any temperature. 2813

BAKERSFIELD, Calif. — U.S. Customs and Border Protection officers executed the second largest methamphetamine bust recently along the southwest borders in CBP's history, according to the U.S. Drug Enforcement Administration.A press release states that a driver of a tractor-trailer with a "shipment that was manifested as medical supplies," pulled up to the Otay Mesa cargo border in San Diego Friday morning. An agent there at the time decided to pull the truck over for a more thorough inspection. Imagining systems, similar to an x-ray, were used to investigate the trailer and revealed suspicious components in the back of the trailer.Officers offloaded more than 1,800 packages mixed with medical supplies. That's when they discovered more than 3,100 pounds of methamphetamine, 64 pounds of heroin, 29 pounds of fentanyl powder, and almost 37 pounds of fentanyl pills. The narcotics are estimated to have a street value of .2 million, according to the press release.“This massive seizure is a testament of what law enforcement agencies can do when we combine forces – prevent over million worth of deadly drugs from entering our country; thus saving countless lives from addiction and overdose deaths,” said DEA Special Agent in Charge John W. Callery. 1271
ATLANTA -- Senator Lindsey Graham said Tuesday he has spoken with election officials in a number of battleground states about their ballot counting procedures.Georgia’s secretary of state said that U.S. Sen. Lindsey Graham asked him whether he had the power to reject certain absentee ballots. Secretary of State Brad Raffensperger told The Washington Post he interpreted the question as a suggestion that he toss out legally cast ballots.Raffensperger said Graham asked him whether political bias might have caused election workers to accept ballots that might have been discarded for non-matching signatures. An accusation that there has been no evidence to suggest.Graham on Monday said that was “ridiculous.” He said he was trying to find out how signature verification for absentee ballots works in Georgia.Raffensperger, also a Republican, has been criticized by President Donald Trump and other fellow Republicans over his handling of the election and said he’s received death threats. He has rigorously defended the integrity of Georgia’s election results.Graham told reporters in D.C. Tuesday he also talked with officials in Arizona and Nevada, specifically to ask them questions about the process for validating signatures on ballots.President-elect Joe Biden is projected to win both Arizona and Nevada, and holds a 13,000 vote lead in Georgia as they finish up a recount.The Trump campaign issued a statement Tuesday afternoon that seemed to support Graham’s line of questioning, without providing evidence.“Georgia officials must continue with their recount efforts to ensure that the American people know the true outcome of the 2020 presidential election, and the Georgia recount must include a thorough matching of signatures,” the statement reads.When Sen. Graham was asked why he was making these calls, he responded he is a “United States senator who is worried about the integrity of the election process nationally, when it comes to vote by mail.” 1977
ATLANTA (AP) — Early in-person voting began Monday in Georgia for the state's two U.S. Senate runoffs.The early voting period runs as late as Dec. 31 in some counties.It could determine the outcome of the races between Republican U.S. Sens. David Perdue and Kelly Loeffler and Democratic challengers Jon Ossoff and Raphael Warnock.A majority of votes before the Nov. 3 general election were cast in person during early voting.The period could be even more important during the runoffs because of the shortened period for voters to request and return ballots by mail.More than 125,000 people cast ballots in October on the first day of early voting. Lines were long then and could be long again Monday. 709
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