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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - A UC San Diego Health professor is one of 85 members in the health and medicine field elected to this year's class of the National Academy of Medicine, UCSD announced today.Dr. Lucila Ohno-Machado is the chair and founder of UCSD's Department of Biomedical Informatics."Bioinformatics and big data are increasingly a foundation and driver of modern medicine. Lucila is an undisputed expert and pioneer in both," said Dr. David Brenner, UCSD's vice chancellor of health sciences. "Her leadership and dedication to scientific excellence make her an ideal NAM member. We are proud of the many research and education programs she has built here, helping UC San Diego remain a leader in these critical fields."The 2018 academy class includes 75 regular members and 10 international members. Current members elect new members each year, focusing on medical professionals who have made significant contributions in the medical science, health care and public health fields. Academy members elected Ohno-Machado for her work creating an algorithm that allows medical professionals to share clinical data while maintaining a patient's privacy, according to the NAM.Ohno-Machado is an informatics and technology professor at the School of Medicine and a founding member of the UCSD Halicioglu Data Science Institute. In addition to her work at UCSD, Ohno-Machado is a research health scientist for San Diego's Veterans Affairs healthcare system, co-leads the 1474

SAN DIEGO (CNS) - Mayor Kevin Faulconer and San Diego Police Chief David Nisleit have launched a digital marketing campaign that aims to fill more than 200 positions that are currently vacant in the department, the mayor announced Thursday.Downtown-based Loma Media will run the marketing campaign, which includes videos that will be shared on social media as well as a new recruitment website, with the goal of fully staffing the department by 2020, Faulconer said."Getting the San Diego Police Department back to full staffing of over 2,000 officers is a top priority," Nisleit said in a statement.In December 2017, the City Council approved an agreement to boost salaries for San Diego police officers through the 2020 fiscal year.Since the raises were announced, the number of officers lost to other law enforcement agencies is down 84 percent from last year, Faulconer said."The best way to keep San Diego one of the safest big cities in the country is by attracting the best and brightest recruits to the San Diego Police Department," Faulconer said in a statement. "We're going to be innovative and creative in how we do that."Loma was one of four companies that responded to a request for proposals issued by SDPD earlier in the year. A panel selected the firm because of its social media expertise and prior clients, which included the U.S. Naval Special Warfare Command, Semper Fi Fund, UC San Diego and Google, among others.The 0,000 contract with Loma, which was approved in June, lasts two years, with an option to extend the contract for up to three more years.Funding for the first two years of the marketing contract was included in the current fiscal year budget. 1691

SAN DIEGO (CNS) - Father Joe's Villages announced Friday that it has established an emergency fund to raise money for the homeless during the COVID- 19 crisis. With its thrift and donation stores shuttered, and donation pick-ups and drop-offs on hiatus as part of the shelter's efforts to reduce the risk of spreading the virus to clients and staff, Father Joe's representatives say the new fund will be crucial to continue to provide shelter, health care, food, showers and laundry for those in need. Qualcomm co-founder Franklin Antonio has provided a 0,000 matching gift challenge in an effort to encourage monetary support from the community, Father Joe's Villages said. Donations can be made online here.While some services have been paused in the wake of the coronavirus outbreak, Father Joe's Villages reiterated there are no confirmed COVID-19 cases at the shelter.One client showed signs of COVID-19 symptoms on Wednesday, leading to a temporary interruption in intakes. However, the client was tested for COVID- 19 and was confirmed negative for the virus Thursday, leading the shelter to resume accepting intakes following direction from county officials. 1177

SAN DIEGO (CNS) - Gov. Gavin Newsom announced Monday the state will send .7 million to support San Diego's proposed purchase of two hotels to provide more than 330 rental housing units for San Diegans experiencing homelessness.The funds -- part of the state's Project Homekey -- will go toward the purchase of the Residence Inn Hotel Circle and Residence Inn Kearny Mesa, to be considered by the San Diego City Council in October.The purchase of the two properties would create 332 permanent supportive housing units, with 72 of the units having two bedrooms, enough to provide housing for more than 400 individuals. According to a city statement, the units were determined to require minimal work before people could move in. The Hotel Circle property was built in 2003, while the Kearny Mesa property was built in 1990 and underwent a renovation in 2013."San Diego has proven we can put state dollars to action on programs and services that reduce homelessness," said Mayor Kevin Faulconer. "We have the real opportunity to house hundreds of individuals with these two hotels, and the Project Homekey grants will go a long way toward achieving that."RELATED: City of San Diego to buy hotels for permanent housing for the homelessThrough the Project Homekey program, the state is making 0 million in grant funding available to local public entities in California, including cities, counties or housing authorities. The grant funds may be used to purchase and rehabilitate housing, including hotels, motels, vacant apartment buildings, and other buildings, and convert them into interim or permanent, long-term housing.Residents of the two San Diego properties would include individuals currently staying at Operation Shelter to Home at the San Diego Convention Center -- which opened April 1 as a temporary shelter during the COVID-19 pandemic and serves about 1,100 people per day."The lack of housing options for our unsheltered residents is a humanitarian crisis, and confronting it is a top priority," said City Council President Georgette Gomez. "The clear solution is more homes, and so the announcement that the city of San Diego will receive substantial funding from Project Homekey to create new apartments with supportive services for some of our most vulnerable unhoused neighbors is very exciting news."The state awarded the funds based on applications the San Diego Housing Commission submitted."Securing two hotels, and bringing online over 330 permanent supportive housing units, is another example of our region implementing recognized best practices to protect the most vulnerable among us during COVID- 19," said City Councilman Chris Ward, who also serves as Chair of the Regional Task Force on the Homeless.The housing commission board voted 6-0 on Friday to recommend that the city council, in its role as the Housing Authority of the City of San Diego, authorize the purchase of Residence Inn Hotel Circle and Residence Inn Kearny Mesa.The County of San Diego Board of Supervisors voted unanimously Aug. 25 to approve Supervisor Nathan Fletcher's request to authorize .4 million to fund essential supportive services for the individuals who would reside at the properties.One of the main objectives of Operation Shelter to Home is to streamline how people experiencing homelessness access housing resources and move them quickly into permanent housing. So far, the project has helped more than 600 people secure housing.According to San Diego's Community Action Plan on Homelessness -- which the City Council adopted in October 2019 -- the city has a critical need to increase permanent supportive housing by 2,659 units for individuals experiencing homelessness within a decade, with 60% of those units, or 1,595, to be developed within the first four years. 3798

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