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WASHINGTON, Oct. 13 (Xinhua) -- U.S. researchers have corrected sickle cell disease in adult laboratory mice that had been bred to have the inherited blood disorder by activating production of a special blood component, according to a study published online Thursday in the journal Science.Sickle cell disease results from an abnormality in hemoglobin, the protein found in red blood cells that is responsible for transporting oxygen throughout the body. People living with sickle cell disease have two copies of an altered gene that produces sickle hemoglobin instead of normal adult hemoglobin. Sickle hemoglobin changes shape after releasing its oxygen, causing the red blood cell to become stiff, misshapen and sticky, and slowing blood flow to tissues. This process damages organs and causes pain.The study tested a new approach to increasing the production of a third form of hemoglobin -- fetal hemoglobin. Production of fetal hemoglobin predominates before birth, but turns off thereafter as adult hemoglobin production takes over. People with sickle cell disease are unable to make normal adult hemoglobin, and instead make sickle hemoglobin starting in infancy.An elevated level of fetal hemoglobin within the red blood cell reduces the tendency of sickle hemoglobin to change the shape of red blood cells. Considerable research has shown that the drug hydroxyurea increases production of fetal hemoglobin and reduces the number of pain crises and other complications of sickle cell disease in adults and children. However, not all patients respond well to hydroxyurea, and adverse side effects are a concern.The current study explores a more targeted approach to increasing fetal hemoglobin production. It builds upon earlier studies that discovered a protein called BCL11A normally suppresses the production of fetal hemoglobin soon after birth. The researchers viewed the BCL11A protein as a target for therapy and decided to see what would happen if they blocked production of the protein.The paper details how the research team silenced the mouse gene that produces the BCL11A protein in mice with sickle cell disease. Silencing the gene turned off production of the BCL11A protein and allowed the adult mice to continue to produce fetal hemoglobin. It appears to have eliminated disease symptoms without affecting other aspects of blood production."This discovery provides an important new target for future therapies in people with sickle cell disease," said Susan Shurin, acting director of the U.S. National Heart, Lung, and Blood Institute, which co-funded the study. "More work is needed before it will be possible to test such therapies in people, but this study demonstrates that the approach works in principle."Approximately 100,000 Americans live with sickle cell disease. It is most prevalent in people of African, Hispanic, Mediterranean, and Middle Eastern descent. There is no widely available cure for sickle cell disease. Bone marrow transplants have cured some patients, but the treatment is not without risk and most patients do not have relatives who can donate compatible and healthy bone marrow to them.

ACCRA, Dec. 19 (Xinhua) -- A strange disease has hit inhabitants of the Amansie West District in the Ashanti Region of Ghana, near Kumasi, 270 km north of the capital, claiming two lives, health officials said here on Monday.Director of Public Health Dr. Joseph Amankwa told Xinhua that the disease, which had been identified as Laffa viral hemorrhagic fever, and had symptoms similar to those of malaria, caused victims to bleed to death.Dr. Amankwa said he received information about the infection over the weekend but indicated that no other details were made available."We are sending a team to the affected area to verify what the actual situation is to determine our next action. We are also liaising with the World Health Organization to gather enough data on the infections and soon information will be sent out to the public," he said.According to reports carried by local Joy fm radio station, the disease was the first of its kind in the country.The reports quoted health officials as saying infection was passed on from infected rodents like mice and rats and was highly contagious."About two months ago, a young man of 19 years came to our health center here and complained of malaria, so we treated him for malaria but suddenly, blood started coming from the nose, mouth, anus and the ears, and immediately he died," Municipal Director of Health in the Amansie West District, Dominic Brobbey told the radio station.He warned that although the situation was under control, there were no drugs to treat the disease in Ghana, and therefore urged government to expedite action to acquire the necessary drugs to prevent further deaths.

SAN FRANCISCO, Oct. 5 (Xinhua) -- Microsoft announced Wednesday that it will bring cable television content to its Xbox video game console over the upcoming holiday season, expanding the console into an entertainment hub.According to the company's press release, nearly 40 world- leading TV and entertainment providers such as HBO GO and BBC will stream their content through the Xbox Live service in more than 20 countries and regions.Users will be able to sift through shows online with the Kinect motion sensor device for Xbox 360 and Bing voice search, Microsoft said.To watch TV programs via Xbox as an alternate delivery system, customers have to already subscribe to the TV services and Microsoft's Xbox Live Gold service of 60 U.S. dollars per year."Today's announcement is a major step toward realizing our vision to bring you all the entertainment you want, shared with the people you care about, made easy," Microsoft said in the press release.Microsoft first entered the gaming console market in 2001 with the Xbox, the predecessor to the Xbox 360. The Xbox 360 currently competes with Sony's PlayStation 3 and Nintendo's Wii as the seventh generation of video game consoles.In June, Microsoft said 35 million people subscribed Xbox Live service around the world, spending an average of 60 hours a month playing games and watching movies and shows. Last year, the company integrated social networking features into Xbox Live, allowing users chat with each other while watching programs.

SUVA, Jan. 21 (Xinhua) -- Three in four people of the Fiji population are physically inactive causing an increase in health risks, says the country's Ministry of Health.National Advisor on Non-Communicable Disease Dr. Isimeli Tukana said that lifestyle in this Fijian generation has changed a lot, especially for the younger population that have been influenced by technology.Tukana said on Friday many children nowadays are obese and that was of growing concern. That is why the Ministry of Health is working with the Ministry of Education in promoting more physical education in schools and making it compulsory from this school term.Fiji was recently ranked the fourth-most obese nation in the region, according to the Health Ministry.Recent studies in Fiji showed a high incidence of anaemia in children, women and men.Figures released by the ministry said more than 60 percent of the island nation's population is overweight while a significant number are deficient in iron and micronutrients.The figures show that the high rate of premature disability with Non Communicable Diseases (NCD), infection and cancer has taken its toll on the population."The importance of our traditional diets, healthy eating and physical activities is paramount," a ministry statement had said."In the Pacific NCDs have reached epidemic proportions," it said."Nutritional imbalances resulting from not eating local produce instead of canned, processed food contribute to the equation, especially in these times of global economic crisis."Women's Minister Dr. Jiko Luveni has advised mothers in the country this week to stock up on healthy foods for their families.She said having green leafy vegetables was vital and buying fruits for children's snacks instead of salted prepacked ones was the way to keep the family healthy.The National Food and Nutrition Council said Friday that as the school year draws parents should find healthy alternatives for their children.They have urged teachers and parents to include fruits in every child's meal to reduce NCDs.In other countries in the region Tokelau and Nauru's obesity rates stand at 93 percent to 93.5 percent of the population.In American Samoa and Kiribati obesity stands at 81.5 percent of the population, while Marshall Islands at 80.1 percent, Federated States of Micronesia (Pohnpei) at 73.1 percent.