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A third leading candidate COVID-19 vaccine has entered a final stage of human testing in the United States. AstraZeneca announced Monday its potential COVID-19 vaccine has entered final trials in the U.S. to test the effectiveness and safety of the product. The Cambridge, England-based company said the trial will involve up to 30,000 adults from various racial, ethnic and geographic groups. The potential vaccine was invented by the University of Oxford and an associated company, Vaccitech.AstraZeneca said development of the vaccine known as AZD1222 is moving ahead globally with late-stage trials in the U.K., Brazil and South Africa. Further trials are planned in Japan and Russia.“To have just one vaccine enter the final stage of trials eight months after discovering a virus would be a remarkable achievement; to have three at that point with more on the way is extraordinary,” Health and Human Services Secretary Alex Azar said in a statement.Two other vaccine candidates began final testing this summer in tens of thousands of people in the U.S. One was created by the National Institutes of Health and manufactured by Moderna Inc., and the other developed by Pfizer Inc. and Germany’s BioNTech. 1215

A Virginia judge has extended the deadline for Virginians to register to vote for two days after a state-run website crashed.The Associated Press reports that U.S. District Judge John A. Gibney, Jr. announced Wednesday that Virginians can now register to vote through this Thursday.The state website where Virginians can register online crashed Tuesday when Gov. Ralph Northam said a fiber optic cable was accidentally cut in a roadside project.This story is breaking and will be updated. 496

A Tennessee woman has called her 6-year-old son's daycare facility negligent after he was left alone outside when it closed early in observance of Veterans Day.Megan Talley, of Parrotsville, Tennessee, told WATE-TV that one of her son's school teachers happened to find him alone and crying outside Precious Memories daycare on Friday afternoon."I almost went into a full blown panic attack," Talley told the TV station. 433

A protester was accidentally run over and killed by a car during a demonstration over rising fuel prices, a top official in eastern France said Saturday.Mass demonstrations causing roadblocks across the country are part of the "gilets jaunes" or "yellow vests" movement, which opposes mounting gas prices and eco-taxes on polluting forms of transport.The death occurred when a driver "panicked" and ran over someone after arriving at a blockade for an undeclared protest not far from the city of Lyon, Louis Laugier, the prefect of the Savoie region, said at a news conference.A further 227 people were injured -- six severely -- in protests across the country, and 73 people were taken into police custody, the Interior Ministry said in a statement. Five police officers suffered slight injuries, and one was severely injured. Another five gendarmes were hurt as well.Speaking about the death, French Interior Minister Christophe Castaner said: "That's the reason why we were worried to have people (who are) not experienced organizing protests."Ecology Minister Fran?ois de Rugy called on citizens to "respect caution and safety recommendations" in order for protests to go ahead "without a new tragedy," in a tweet Saturday. He also offered his condolences to the family of the victim.More than 1 million people were expected to turn out Saturday for demonstrations across the country. Partway through the day, the numbers were much lower than that.About 280,000 people participated in more than 2,000 demonstrations, the Interior Ministry said."Honestly we're satisfied, even if it's true we are not hundreds of thousands people here, but still, people have come. The day is not over yet, and we're glad that there are no incidents here," Thierry Paul Valette, who helped organize a protest on the Champs Elysées in Paris, told CNN."We can't stand Macron's taxes any more. It's too much. We couldn't make ourselves heard through political parties or trade unions, so we had to do something."The protest was billed as likely to be one of the toughest tests yet of Emmanuel Macron's 18-month-old presidency.Website blocage17novembre said protests were planned in all 95 of France's mainland departments, while a petition on change.org calling on the French government to lower the cost of fuel has gotten more than 850,000 signatures.In addition to concerns over spiraling fuel prices, the protests also reflect long-running tensions between the metropolitan elite and rural poor. 2490

A person with knowledge of the punishment tells The Associated Press that at least three NFL coaches and their teams have been fined because their coaches weren't wearing face coverings on the sidelines at all times. The person says the three coaches who were fined are Vic Fangio of the Denver Broncos, Pete Carroll of the Seattle Seahawks and Kyle Shanahan of the San Francisco 49ers. The coaches were fined 0,000 each and their teams 0,000 each. Other fines could be coming as several other coaches violated the rules a week after the league sent out a memo reminding them to wear face coverings over their noses and mouths to protect against the spread of the coronavirus. 690