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Maryland-based vaccine developer, Novavax, has received .6 billion from the federal government to complete late-stage clinical development; set up large-scale manufacturing; and deliver 100 million doses of NVX?CoV2373, its COVID-19 vaccine candidate, as early as late 2020.This is the largest vaccine deal to date with the Trump administration as part of their Operation Warp Speed, which is focused on making a COVID-19 vaccine and treatments available as quickly as possible.Novavax has not brought any of their developed vaccines to market. According to information on their website, they have developed several vaccines for infectious diseases, however they are all in various stages of development or clinical trials. These include vaccines for the seasonal flu and RSV. Other vaccines created by Novavax are not actively being developed or studied at this time, including ones for Ebola, MERS, and SARS.According to a statement from Novavax, the agreement with the federal government includes the company demonstrating being able to rapidly get manufacturing and large-scale production of the vaccine going once approved. Novavax hopes to conduct their late-stage clinical study with 30,000 subjects in fall 2020.An early-stage clinical study took place in Australia in May on 130 participants. Study results are expected at the end of July.“Today’s .6 billion investment supports the Novavax candidate, depending on success in clinical trials, all the way through to manufacturing 100 million doses for the American people,” said U.S. Health and Human Services Secretary Alex Azar.Regeneron Pharmaceuticals has also received 0 million through Operation Warp Speed on Tuesday, to make and supply its COVID-19 vaccine candidate, REGN-COV2. Their vaccine is currently in phase 2 and phase 3 clinical studies for the treatment and prevention of COVID-19.Regeneron has several vaccines on the market currently, including Dupixent, used to treat allergic diseases such as eczema, asthma and nasal polyps which result in chronic sinusitis, and Praluent, used to treat high cholesterol. 2101

Many small businesses are struggling after the pandemic shut down a number of industries. Recently, more than 2,400 small businesses gave their thoughts on how various levels of government are helping them during this tough time.Nate Chai, who heads up the Pro Engagement Team at Thumbtack, says "the purpose of the survey is really to find out how small businesses across the country feel about the public policies that they're working with at the local, state and national levels. Do they feel supported? Do they feel the right policies are in place? Are things changing year-over-year for them?"Thumbtack, an online company that connects people with local independent professionals in industries like construction, wellness and music, conducts a small business friendliness survey every year. This year, they wanted to check in with the small businesses on their site to see how they were doing amid this COVID-19 pandemic."What we did notice is that there were strong divergent between how many felt their states and local governments were doing versus what they saw from the federal government. To put that in perspective, we saw many states score A, A- or B in terms of that local response but at the federal level people almost universally what people were seeing was not good enough," said Chai.Chai says overwhelmingly, small business owners gave the federal government an F when it came to their response. "We saw several states earn Fs and unfortunately the worst of those, starting from the bottom up were Arizona followed by Oregon, Missouri, Georgia and Tennessee," said Chai. The highest ranked states were Vermont, which received an A+, followed by A ratings for Rhode Island, Connecticut, Massachusetts and an A for Maryland. Gerard Cassagnol, the Engineering and Operations Manager for Trevor Technical Solutions in Maryland, took part in the survey."It started off really good here in Maryland. They were very proactive in how to address the pandemic. What I basically mean is they were going by the science," Cassagnol said. Cassagnol says the funding, though, from State and Federal levels, was lacking, as well as information and guidance about programs and how to operate has been inconsistent. Cassagnol says before the pandemic, 80 percent of his company's revenue came from work from the government. Over the last three months, that dwindled down to 5 percent, putting his business in a dire state and prompting him to lay off staff. "It's a survival instinct right now that we're operating on," said Cassagnol.Of the roughly 2,400 businesses that took the survey, 65 percent had only one employee, in that the person owned their business and works alone; 28 percent had two to five employees and the remaining six percent had more than six employees."Given what’s going on, it's a great time to consider reaching out to small businesses if you’ve got those projects on the back burners, and finding ways to support small businesses if you have the means," said Chai."We've got to find a solution to this. America is going to suffer ultimately if the small business isn't there," said Cassagnol. Thumbtack is encouraging people to support their local businesses in any way they can right now as many feel uncertain when or if they will recover from this economic downturn. 3306

MEXICO CITY (AP) — Mexican authorities said a group of about 350 migrants broke the locks on a gate at the Guatemalan border Friday and forced their way into southern Mexico to join a larger group of migrants trying to make their way toward the United States.The National Immigration Institute did not identify the nationalities of the migrants, but they are usually from Central America.A similar confrontation occurred on the same border bridge between Mexico and Guatemala last year.RELATED: Where federal government falls short, San Diego agencies fill in to help migrantsThe institute said the migrants were acting in a "hostile" and "aggressive" way, and accused them of also attacking local police in Metapa, a Mexican village that lies between the border and the nearby city of Tapachula.The group of 350 pushed past police guarding the bridge and joined a larger group of about 2,000 migrants who are walking toward Tapachula in the latest caravan to enter Mexico.Claudia Jaqueline Sandoval, 43, from El Progreso, Honduras, was walking toward Tapachula with her 6-year-old daughter. Another son and a daughter are already in the United States.RELATED: Judge blocks Trump's asylum policy but delays enforcement"I have been HIV positive for 16 years," said Sandoval, but her reason for going north was not just medical treatment. "It has been two years since I heard from my son" in the United States, and money is scarce, she said.There are already several groups of migrants in the southern border state of Chiapas who have expressed frustration at Mexico's policy of slowing or stopping the process of handing out humanitarian and exit visas at the border.A group of several hundred Cuban, African and Central American migrants have been waiting at the immigration offices in Tapachula for documents that would allow them to travel to the U.S. border, where most plan to request asylum.RELATED: Mexico is apprehending more migrants. Is it because of Trump?Some members of that group have scuffled with immigration authorities and broken windows at the offices in recent days, accusing officials of making them wait too long for papers.And another group of an estimated 2,500 Central American and Cuban migrants have been stuck for at least a week further west in the Chiapas town of Mapastepec, also waiting for papers. 2337

LOUISVILLE, Ky. – This year’s Kentucky Derby will be held with spectators, but “under strict guidelines."Churchill Downs Racetrack made the announcement Thursday after consulting with Gov. Andy Beshear and state public health officials.The Derby is set to take place on Saturday, Sept. 5 after being postponed from its original date, Saturday, May 2.Churchill Downs says its plan was developed in conjunction with advice and counsel from the Louisville Metro Health Department and Kentucky’s Healthy at Work guidance.Some of the steps that will be taken to ensure guest and employee safety include:Venue capacity reductions to limit overall crowd density, including general admission, outdoor reserved seating, premium dining and suites. More information on ticketing and seating areas will be released in the coming days and also will be sent directly to ticket holders.Access throughout the facility will be severely limited.Credentials for employees, media and guests will be reduced.Barn area access will be restricted to essential personnel. Guests and parties in the barn area for morning workouts and during race days will be eliminated.Changes in venue operations to limit person-to-person touchpoints.Team member protocols established to protect employees and guests.A revised "Fan Code of Conduct" will also be in place that establishes expectations for guests coming to the Derby:Guests will be consistently and frequently encouraged to wear a mask at all times unless seated in their reserved seat or venue, including when riding on a shuttle, traveling through the venue, going to the restroom, placing an in-person wager, and purchasing food or beverages from a concession stand. Guests will be asked to wash their hands for 20 seconds or sanitize them frequently.Guests will be encouraged to socially distance themselves from others when possible.Tickets purchased for the originally scheduled Kentucky Derby Week dates are automatically valid for the new race dates. Guests may arrive on the new dates in September with their printed ticket or mobile ticket to be scanned for entry at the gates. Click here to learn more about tickets.“We truly appreciate the leadership of the Governor of Kentucky, Andy Beshear, and all of the hard work, collaboration and guidance that state and local officials and public health experts have provided us to safely and responsibly host Kentucky Derby Week in September with spectators,” said Churchill Downs Racetrack President Kevin Flanery. “Our team is deeply committed to holding the very best Kentucky Derby ever, and we will take all necessary steps to protect the health and safety of all who attend and participate in the Derby. In response to the COVID-19 pandemic, we have established a comprehensive set of operating procedures, which include a multitude of precautionary measures to be followed while fans are in attendance at our facility. We are determined to keep our customers, employees and communities as safe as we responsibly can.” 3011

MEXICO CITY (AP) — Mexico's office for environmental protection says it has filed a criminal complaint against the organizers of the Score Baja 1000 off-road race for damaging protected desert areas.The office said Thursday that some participants in the Nov. 14-18 race departed from agreed-on routes and damaged cactuses and other desert plants in the Valle de los Cirios protected area. Inspectors found damaged choya, agave and cardon plants.Score International spokesman Juan Tintos Funcke says the Reno, Nevada-based company has not received any formal notification from Mexican authorities. Tintos Funcke's statement adds that "as soon as we do we will coordinate ourselves with them in order to attend to it."The race starts from Ensenada in Baja California state. 779

来源：资阳报