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SAN DIEGO (KGTV) -- San Diego is home to some impressive pieces of property, but for many people those places are pure fantasy. The reality is that many San Diegans can't even find a place to rent, let alone buy.At least 70 percent of San Diegans can't afford to buy a house at the county's median home cost of 0,000. In an interview with 10News, Mayor Kevin Faulconer said housing is also one of the most complex and challenging issues to tackle, especially when it comes to the middle class."That missing middle has really been, not only here in San Diego, but up and down the state of California what has been so desperately needed," said Faulconer. 688
SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

SAN DIEGO (KGTV) — San Diego Mayor Kevin Faulconer and President Trump may have met in the Oval Office Tuesday, but their accounts of what was discussed differ.Faulconer visited the White House this week to discuss the United States-Mexico-Canada Agreement and raise concerns over polluted water flowing in the Tijuana River Valley. Following the meeting, Faulconer confirmed the topics on Twitter, saying, "We talked about the pending #USMCA deal, California’s homeless crisis, and I also brought up sewage coming from the Tijuana River Valley – and encouraged more federal action to fix it."Though Wednesday night, the President told Fox News' Sean Hannity, another topic came up: "The wall."RELATED: Mayor Faulconer meets with President Trump to discuss issues facing San Diego“We just finished San Diego, as you know, San Diego, in California. They’re so happy. The mayor was just up in my office, great guy. He came up to thank me for having done the wall because it’s made such a difference. He said, it’s like day and night. He said people were flowing across and now nobody can come in,” Trump said.This didn't happen, Faulconer's director of communications, Craig Gustafson, says.“That’s not what Mayor Faulconer said. We all know that the President uses his own terminology. But that wasn’t the focus of their conversation," Gustafson said. "The President as an aside asked Mayor Faulconer what he thought about the border, and the Mayor’s response is that we welcome federal investment in our land ports of entry. We're the busiest border crossing in the Western Hemisphere, and federal dollars help us make it easier to trade, cross legally and commute across the border."RELATED: Official: ICE to begin immigration raids in 10 cities on June 23Gustafson continued, "Mayor Faulconer said to the President that the border does not define San Diego's relationship with Mexico. Trade does, and that’s why he’s so focused on getting the USMCA trade agreement approved by Congress. Mayor Faulconer doesn’t support a wall from sea to shining sea. Let’s invest instead on stopping sewage from the Tijuana River Valley.”The mayor's press secretary, Ashley Bailey, told City News Service Tuesday that immigration was not discussed between the two. Faulconer was originally scheduled to meet with the White House Intergovernmental Affairs Team, before Trump heard Faulconer was in Washington and invited him to meet.Sections of old border wall have been replaced along San Diego's border recently, including a 14-mile stretch of newly constructed primary and secondary border wall just east of Otay Mesa. 2614
SAN DIEGO (KGTV) — San Diegans have been waiting patiently for several popular holiday traditions to return to town. That time has finally arrived!Special holiday events like the Old Globe's production of "The Grinch," trips to the North Pole out of Campo's North Pole Limited express, Christmas on the Prado, Escondido's Winter Wonderland Festival pack yuletide cheer, treats, and shopping into grand events.There's even a little snow in the forecast for some events.RELATED:San Diego holiday tree lightings to catch this seasonTurkey trots, holiday runs in San Diego this seasonSkate away on one of San Diego's outdoor ice rinks this holiday seasonThe fun for many of these events starts early in November, giving everyone plenty of chances to experience one of San Diego's holiday traditions.Dr. Seuss' How the Grinch Stole ChristmasWhere: Old Globe Theater; When: Nov. 10-Dec. 29The annual Old Globe run of "How the Grinch Stole Christmas" returns through Dec. 29. Take in the performance of the beloved Dr. Suess tale as the theater is transformed into Who-ville for the holiday season.Santa Train North Pole LimitedWhere: Campo; When: Fridays and Saturdays, Nov. 29 - Dec. 21Bring the kids on a journey aboard the North Pole Limited in Campo. The train stops at Santa's Workshop for a special visit and travelers enjoy treats, carols, and stories along the way. Christmas on the PradoWhere: Balboa Park; When: Nov. 30Christmas on the Prado brings tons of Christmas fun to Balboa Park's Organ Pavilion and International Cottages, including holiday kids crafts, photos with Santa, music, delicious seasonal treats, and a tree lighting.SoNo Fest & Chili Cook-OffWhere: North Park; When: Dec. 1It's not a "holiday" event, but chili is best enjoyed when its cold outside! The annual cook-off features delicious chili, three stages of live music, and vendors with handmade holiday gifts.December NightsWhere: Balboa Park; When: Dec. 6-7December Nights will cover Balboa Park in holiday cheer with light displays, bands and performances, attractions, shopping, and delicious foods from the park's International Cottages to Spanish Village.Winter Wonderland FestivalWhere: California Center for the Arts; When: Dec. 7The North Pole comes to Escondido as visitors enjoy real snow, winter-themed arts and crafts, holiday entertainment, reindeer, and a visit from Santa during the Winter Wonderland Festival. Little Italy's Christmas VillageWhere: India Street, Little Italy; When: Dec. 7Little Italy will become a Christmas village at Piazza della Famiglia with a grand tree lighting ceremony, live music, carriage rides, holiday snacks, vendors for all your holiday shopping, and a visit from Santa.Chula Vista Starlight Children’s FaireWhere: Third Avenue; When: Dec. 7The Starlight Children's Faire will entertain kids with a snow hill, sledding, games and prizes, and photos with Santa before the annual Starlight Parade kicks off on Third Ave.La Mesa's Holiday in the VillageWhere: La Mesa; When: Dec. 13-14Holiday in the Village returns to downtown La Mesa with holiday music and dance, delicious treats, children's activities, shopping, and more yuletide fun over two days.San Diego Santa RunWhere: Pacific Beach; When: Dec. 14San Diego Santa Run hits Pacific Beach as thousands of runners clad in red hats and white beards will dash through the beachside town. Afterward, the fun continues with the annual Pacific Beach Holiday Parade. 3448
SAN DIEGO (KGTV) — San Diego court records show a history of legal disputes with Clark Construction Group, the company that employed the worker who died in yesterday’s accident on a construction site at UC San Diego.10News found a court complaint over the 2017 death of a driller. Frederick Von Kahl's family sued Clark Construction and other defendants for negligence, alleging they created a dangerous workplace at a San Ysidro job site which reportedly caused a valve to strike Kahl in his chest.Friday afternoon, Kahl family attorney Benjamin Bunn said that the case just recently moved into a settlement agreement. He said that Kahl had been married for 40 years.The Occupational Safety and Health Administration (OSHA) website revealed that it issued violations and a ,260 fine. In another negligence case, a worker sued Clark Construction Group and other defendants over a 2010 accident at the San Diego Marriot & Marina Hotel, claiming that a large piece of concrete dropped through a roof and struck a worker's body and right arm. The case was later dismissed.There's also a negligence suit that settled after a 91-year-old woman reportedly suffered broken bones from a fall while walking by a downtown construction site that she claimed was unsafe.The Division of Occupational Safety and Health of California (Cal/OSHA) has done at least 10 investigations into the company in the last 10 years. A Cal/OSHA spokesperson said Thursday that most of the investigations involve complaints from workers reporting unsafe conditions, with no violations issued. However, Clark Construction was reportedly issued two safety violations and a ,000 fine in 2014 over a project in Riverside, California. 1715
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