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WASHINGTON, Oct. 13 (Xinhua) -- In a trial that included about 35,000 men, those who were randomized to receive daily supplementation with vitamin E had a significantly increased risk of prostate cancer, according to a study published this week in the Journal of the American Medical Association.The study followed more than 35,533 men 50 or older at 427 sites in the United States, Canada and Puerto Rico. The men were divided into four groups who took daily doses of 400 international units of Vitamin E and 200 micrograms of selenium; Vitamin E and a placebo that looked like selenium; selenium and a placebo that looked like Vitamin E; or two placebos. The recommended daily intake of Vitamin E is about 22.4 international units.The researchers from the Cleveland Clinic found that the rate of prostate cancer detection was greater in all treatment groups when compared with placebo but was statistically significant only in the vitamin E alone group -- a 17 percent increased rate of prostate cancer detection. The difference in rates of prostate cancer between vitamin E and placebo became apparent during the participants' third year in the trial. The elevated risk estimate for vitamin E was consistent across both low- and high-grade disease."The observed 17 percent increase in prostate cancer incidence demonstrates the potential for seemingly innocuous yet biologically active substances such as vitamins to cause harm. The lack of benefit from dietary supplementation with vitamin E or other agents with respect to preventing common health conditions and cancers or improving overall survival, and their potential harm, underscore the need for consumers to be skeptical of health claims for unregulated over-the-counter products in the absence of strong evidence of benefit demonstrated in clinical trials," the researchers said.
WASHINGTON, Dec. 12 (Xinhua) -- British scientists have discovered a new way to target cancer through manipulating a master switch responsible for cancer cell growth. The findings, published Monday in the U.S. journal Cancer Cell, reveal how cancer cells grow faster by producing their own blood vessels.Cancer cells gain the nutrients they need by producing proteins that make blood vessels grow, helping deliver oxygen and sugars to the tumor. These proteins are vascular growth factors like VEGF -- the target for the anti-cancer drug Avastin. Making these proteins requires the slotting together of different parts of genes, a process called splicing.Scientists at the University of West England and the University of Bristol discovered that mutations in one specific cancer gene can control how splicing is balanced, allowing a master switch in the cell to be turned on. This master switch of splicing makes cancer cells grow faster, and blood vessels to grow more quickly, as they alter how VEGFs are put together.In experimental models, the researchers found that by using new drugs that block this master switch they prevented blood vessel growth and stopped the growth of cancers."The research clearly demonstrates that it may be possible to block tumor growth by targeting and manipulating alternative splicing in patients, adding to the increasingly wide armory of potential anti-cancer therapies," the authors said.

BEIJING, Jan. 8 (Xinhua) -- China's central authorities have highlighted travel safety as the nation on Sunday officially kicked off the world's largest holiday migration, a time in which mass numbers of passengers will be homeward bound for the traditional Chinese Spring Festival.Safe travel has emerged as a hot-button issue facing the government as passenger trips during the 40-day travel peak are expected to hit a record high of over 3 billion.Liu Tienan, vice chief of the National Development and Reform Commission, the country's top economic planner, told the press on Sunday that passenger transport during the period is not looking good as the enormous migration outweighs existing transportation capacities.?A volunteer guides passengers to their train at Chengdu Railway Station in Chengdu, capital of southwest China's Sichuan Province, Jan. 7, 2012. Starting from Jan. 8, 2012, China's transport system will undergo a 40-day travel rush, which is characterized by a hightened passenger flow around the time of the oncoming Chinese New Year.Liu warned of the likelihood of heavy snow and icy rain that could hamper travel while vowing greater efforts to avoid another travel disaster, as was seen in early 2008 when unprecedented heavy snow and freezing rain inundated the south of the country, bringing traffic to a standstill during the peak holiday season.A total of 3.16 billion passenger trips are expected during the next 40 days, up 9.1 percent from a year earlier, of which, 235 million trips will be made via the country's railways, up 6.1 percent year-on-year.Hu Yadong, vice minister of railways, said a daily average of 5.88 million people will make train trips during the period, 340,000 more than the corresponding period in 2011.At the Beijing Railway Station on Sunday, staff members checked passengers' train tickets and ID cards, as an ID-based train ticket purchasing system kicked off nationwide at the start of the new year in an effort to curb ticket scalping.
BEIJING, Oct. 27 (Xinhuanet) -- A new study shows that it's not simply a lack of willpower that explains weight regain but hormones keep one insisting on eating, a persistent biological urge. As any dieter knows, it's hard to keep weight off. Weight regain is a familiar problem for dieters. The research appears in Thursday's issue of the New England Journal of Medicine. To study what drives it, Proietto and his colleagues enrolled 50 overweight or obese patients in Australia in a 10-week diet program. On average, the participants lost almost 30 pounds in the 10 weeks - faster than the standard advice of losing a pound or two per week. Even so, they gained an average of 12 pounds back over the next year. The scientists checked the blood levels of nine hormones known to influence appetite - and found that even a year after the end of the weight-loss program, six of the hormones were still out of whack. People who regain weight should not be harsh on themselves, as eating is our most basic instinct, study author Joseph Proietto of the University of Melbourne in Australia said. It's better not to gain weight than to try to lose it.
来源:资阳报