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People look at a W154 Mercedes Benz racing car at a vintage car show marking the German car maker's 125 anniversary at the former Tempelhof airport in Berlin, August 27, 2011.

WASHINGTON, Sept. 12 (Xinhua) -- An enzyme that appears to play a role in controlling the brain's response to nicotine and alcohol in mice might be a promising target for a drug that simultaneously would treat nicotine addiction and alcohol abuse in people, U.S. researchers find.Over the course of four weeks, mice genetically engineered to lack the gene for protein kinase C (PKC) epsilon consumed less of a nicotine-containing water solution than normal mice, and were less likely to return to a chamber in which they had been given nicotine. In contrast, normal mice steadily increased their consumption of nicotine solution while the mice lacking PKC epsilon did not.The study conducted by researchers at the Ernest Gallo Clinic and Research Center, affiliated with the University of California, San Francisco, appeared Monday in the online edition of the Proceedings of the National Academy of Sciences.In normal mice, as in humans, nicotine binds to a certain class of nicotinic receptors located on dopamine neurons, which causes dopamine to be released in the brain. Dopamine creates a feeling of enjoyment, and thus prompts a sense of reward. Researchers found that mice lacking PKC epsilon are deficient in these nicotinic receptors.The finding complements earlier research in which researchers found that mice genetically engineered to lack the PKC epsilon enzyme drank less alcohol than normal mice and were disinclined to return to a chamber in which they had been given alcohol."This could mean that these mice might not get the same sense of reward from nicotine or alcohol," said Gallo senior associate director and investigator Robert Messing. "The enzyme looks like it regulates the part of the reward system that involves these nicotinic receptors."The reward system is a complex of areas in the brain that affect craving for nicotine, alcohol and other addictive substances.The next step in the research, said Messing, would be to develop compounds that inhibit PKC epsilon. The ultimate goal, he added, would be medications that could be used "to take the edge off of addiction by helping people get over some of their reward craving."

LOS ANGELES, June 29 (Xinhua) -- The war on cloud intensified as Microsoft Office announced its decision on Tuesday to go cloud in an attempt to compete with its immediate but not last competitor, Google Docs.Microsoft holds a virtual monopoly on office productivity software. Most computer users in the world use the Office software for word processing, spreadsheet, presentation and other purposes. However, Microsoft Office faces a strong enemy -- Google Docs, which provides cloud service, that means users do not have to purchase any software to be installed on their computers. If they go online, they can start use the application, and they do not need to worry about their files, because the files also go with the cloud, and users can get access to their files at anytime, anywhere.The cloud-based Office 365 is designed for the mobile age when people go with their software and documents.The actual features and functionality of the tools have a lot of bearing on which productivity suite users choose. The Word Web App is more visually appealing and polished than its Google counterpart, but overall the two seem roughly equivalent in features.When tested on a sample presentation in both the PowerPoint Web App and Google Docs Presentation, the PowerPoint Web App immediately presented with a diverse selection of attractive themes to choose from, but Google defaulted to plain black text on a plain white background.On slide and image, in Google Presentations, the image filled the whole slide but the PowerPoint Web App was smart enough to size the image automatically.When push comes to shove, the features of the Office Web Apps in Office 365 are pretty much the same as what Google Docs has to offer. However, Microsoft makes key features easier to get to, and works more intuitively. For users already familiar with Microsoft Office, the Office Web Apps version is easy to use.Both Office 365 and Google Docs are Web-based platforms, and they will work from any Web browser. Google Docs excels in the Chrome browser while Microsoft Office 365 works best in Internet Explorer. It makes sense that each would make sure that their online productivity tools are optimized for performance and functionality in their own browser.Collaboration in real time is the primary selling point of Google Docs, which can be shared with any other Google account. The users who share a file can all access and work with it simultaneously. Each user is assigned a unique color so users can easily identify who is making changes to what.But in the price war, Microsoft can not beat Google Docs. Office 365 starts at six dollars per user per month for the Professional and Small Business plan. The Medium Business and Enterprise plans range from 10 to 27 dollars per user per month. But the Google Docs is free.Microsoft also faces a challenge on how to go cloud while still keep the computer-based Office software.Statistics showed that nearly nine of every 10 office computers runs one of the 14 versions of Office the company has released since the software's launch in 1989. The company now needs to convince those computer users, estimated at about one billion, to switch to Office in the cloud without disrupting the legacy version that is financing the transition.The growing cloud market is profitable. The International Data Corp. projected the market for cloud-computing services and software is expected to grow more than 27 percent annually over the next five years and reach 73 billion dollars by 2015.It is estimated that by 2015 one of every seven dollars spent on technology will be connected with cloud computing and the winners of the cloud platform wars will likely be the new power brokers of the IT industry.It is reported that Salesforce.com has added a communication technology called Chatter to its service to allow clients to communicate within its sales management cloud service. Amazon's Elastic Cloud has attracted enterprise customers because of its ability to scale up capacity to match peaks in client demand.By 2015, it is estimated that software-oriented cloud services will account for roughly three-quarters of all spending on public cloud services. Enditem

SAN FRANCISCO, Sept. 13 (Xinhua) -- Researchers in San Francisco, U.S. have found in a latest study that bisphenol A (BPA) and methylparaben, two chemicals commonly used in consumer products, can interfere with the breast cancer drugs, local media reported on Tuesday.In the study, doctors from California Pacific Medical Center in San Francisco found that healthy breast cells from high-risk patients started to find ways to bypass breast cancer drugs after they were exposed to BPA and methylparaben in the lab.The cells exposed to the two chemicals kept growing and didn't die after they were introduced with Tamoxifen, a current standard drug therapy for female breast cancer and most common used treatment for male breast cancer, Dr. William Goodson, lead author of the study, told San Francisco Chronicle.Goodson said that BPA and methylparaben not only mimic estrogen 's ability to drive cancer, but appear to be even better than the natural hormone in bypassing the ability of drugs to treat it. The finds have been published online in the British medical journal Carcinogenesis.The research shows more evidence of safety issues of BPA, a chemical primarily used to make plastic baby bottles, food containers, household electronics and etc, as well as the less known methylparaben, a chemical preservative used in cosmetics and other personal care products.The researchers noted that the breast cancer rates have been growing by about the same amount in men as in women over the past three decades. Scientists have been looking at environmental causes for the disease and wondering where the hormones are coming from.Goodson said BPA and methylparaben are used so widely and even found in household dust, noting that it is still unknown whether the effects of exposure to the chemicals are reversible.Since 2008, several governments issued reports questioning the negative health effects of BPA, especially raising concerns regarding exposure of fetuses, infants and children. BPA use has been banned in baby bottles in a lot of countries and regions.As for methylparaben, the U.S. Food and Drug Administration said on its website that "at the present time there is no reason for consumers to be concerned about the uses of cosmetics containing parabens (including methylparaben)."