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SAN DIEGO (KGTV) - After moving to San Diego almost three years ago, Derek and Terri Ruff are on a mission to experience everything the city has to offer. “Yes we are, it’s fantastic! We hardly leave the county, there’s just so much to do," said Derek.The couple moved here from New Mexico, and for nine years Derek's colon cancer seemed to be behind them. “I won’t say cancer-free, but I didn’t have any symptoms for years, until last May, whenever I came in for a checkup, and they discovered cancer again," said Derek.It was stage IV metastatic colon cancer.“It’s a lot. It’s a tough diagnosis, it’s really difficult to live through.”After three months of aggressive chemotherapy, Ruff's condition only got worse. His journey brought him to UC San Diego Health's Moores Cancer for a clinical trial, which unfortunately did not work. But he Ruff became a candidate for another trial involving natural killer cells created from stem cells.“These are patients who don’t have a lot of good options in terms of chemotherapy or immunotherapy," said Dr. Sandip Patel, a medical oncologist who is leading the trial at UCSD. Decades of research on natural killer cells have culminated in the new cancer treatment being developed by San Diego-based Fate Therapeutics.Fate is the first to mass produce cancer-killing cells from a type of stem cell called a human-induced pluripotent stem cell (iPSC). "The concept of utilizing the stem cells that are within us, within our blood factory, within our blood marrow, to create a master bank of cells that we can utilize to program in different ways to fight cancer with cellular immunotherapy."The off-the-shelf, iPSC-derived natural killer cell cancer immunotherapy received U.S. Food and Drug Administration approval to move into clinical trials in November 2018. Ruff is the first person in the world to receive the treatment and got his first dose in February.“Being the first is exciting but it was less so hearing that you have stage iv cancer and you don’t have much of a future, and now I feel hopeful, again," said Ruff.While it's too early to tell if the treatment is working, researchers are hopeful this treatment will one day help many cancer patients. 2212

SAN DIEGO (KGTV) - Almost 2,000 people gathered in San Diego to honor Dr. Martin Luther King Jr. Friday at the 38th annual Human Dignity Award breakfast in Mission Valley. “He fought and gave his life not just for African Americans but for everyone,” said Dee Sanford, this year’s honoree. Sanford stared a telecommunications business in 1994, was an adjunct professor at colleges, and created public access television and radio stations. “You don't do it for honor but when someone remembers and acknowledges your work, it’s really a humbling experience,” she said. RELATED: San Diego to celebrate Martin Luther King Jr. at annual paradeSanford said she remembered when Dr. King’s life was taken. “I knew about him when I was a young woman. My father was part of the civil rights movement. He was our king,” said Sanford. Organizers said they hoped the event, which was held at the Town and Country Hotel, would leave each attendee inspired to help someone or do something good. Dr. King would have been 91 years old this year. 1036

SAN DIEGO (KGTV) - Almost seven years after she was found hanging from a bed at the Spreckels Mansion in Coronado, the trial over Rebecca Zahau's death will begin Monday with jury selection. 198

SAN DIEGO (KGTV) - A simple move across the city could bring San Diegans more help when it comes to finding a job.Monday, the San Diego Workforce Partnership relocated from its longtime office in City Heights to a new headquarters in Kearny Mesa. The partnership expects to save 0,000 in rent this year and million over the next fifteen years."That's more staffing, more services for job seekers, and more outreach to employers," said Peter Callstrom, the Workforce Partnership's CEO. "To save money is the big deal because we want to keep costs low and fund programs."San Diego Unified bought the partnership's old office, getting them out of a long term, expensive lease. The partnership, a quasi-public agency, funds six job centers in the county and more than 30 training programs.For more information on its offerings, visit workforce.org. 859

SAN DIEGO (KGTV) — A San Diego-based biotech company appears to be making huge strides with its experimental COVID-19 vaccine after testing it on monkeys.Inovio Pharmaceuticals is one of more than 100 companies working on a vaccine. It’s one of few to make it to human clinical trials.“We’re much closer to finding a safe and effective vaccine,” said Dr. Kate Broderick, the VP of Research and Development for Inovio. “We’re so excited and feel so confident about the results we’ve got both in animals and our human clinical trials.”Broderick said clinical trials had shown positive results regarding the safety of Inovio’s experimental vaccine.“Our phase one has been our U.S. based trial, and we’re about to start a trial in China,” she said. “We really are looking to test the vaccine all over the world. The immune responses that these people have generated after getting the vaccine, we’re so pleased with those because they’re really broad.”She said the latest positive development came from testing the vaccine on monkeys in what’s called an Animal Challenge Study.“Those monkeys received their vaccine, then just after four months later they received the virus itself, we were able to show they were protected from that,” she said. “What we were able to show in the lungs, and the nose is that those monkeys really were protected from the symptoms of COVID-19.”It will take some time to ensure all testing is done correctly, and the potential vaccine is safe before it is given to the general public.“Realistically we should be looking at a vaccine being available for certain members of the public at the end of 2021,” she said. “Most vaccines historically take 5 to 10 years to be generated and developed; this is really a short time frame.”Broderick, a busy working mom with two young kids at home, hopes the positive results will ease the minds of those anxiously waiting to get back to normal.“I do just want to let you know there is light at the end of the tunnel; there is hope out there,” she said. “Our vaccine is looking very promising there’s other vaccines out there that are looking very good.” 2123

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