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LONDON (AP) — Oxford University says trials of a coronavirus vaccine that it is developing with pharmaceutical company AstraZeneca will resume, days after being paused due to a reported side-effect in a patient in the U.K. The university said in large trials such as this “it is expected that some participants will become unwell and every case must be carefully evaluated to ensure careful assessment of safety.” It said globally 18,000 people have received the vaccine so far. Oxford insisted that it is “committed to the safety of our participants.” Pauses in drug trials are commonplace. The Oxford-AstraZeneca vaccine is seen as one of the strongest contenders among the dozens of coronavirus vaccines being tested. 728

LOS ANGELES (AP) — Southern California residents faced with the loss of lives and homes in a huge wildfire also are grappling with the destruction of a vast swath of public lands that are popular destinations for hikers, horseback riders and mountain bikers.The Woolsey Fire has charred more than 83 percent of National Park Service land within the Santa Monica Mountains National Recreation Area, where officials announced Wednesday that all trails were closed."We understand that folks are curious about how their favorite park spots fared. We promise to share that ASAP," the park service tweeted, warning that the blaze was still active after burning for nearly a week.Three people have been found dead in fire zone, which spans 153 square miles (396 square kilometers).RELATED: Malibu residents frustrated by fire recoveryThe fire broke out Nov. 8 and quickly became one of the largest and most destructive in state history. Firefighters have made steady progress this week, getting it more than halfway contained, but warned many hotspots remain.A massive burn scar encompasses more than 30 square miles (80 square kilometers) within the recreation area that stretches from beaches to inland mountains straddling Los Angeles and Ventura counties. It's the largest urban national park in the nation, with more than 30 million visitors every year.Cyril Jay-Rayon, 52, watched the news with despair as flames engulfed what he called his "main playground" — a rugged area where he rode his mountain bike a few times a week. It includes the famous Backbone Trail, a 65-mile (104-kilometer) route that offers challenging terrain for bikers and hikers who are rewarded with soaring views of the Pacific Ocean."It's just devastating. Those trails are my sanity. It's where I ground myself," he said. "I love the city, but I also love how easy it is to get out into the wild."People share their recreation areas with wildlife, including 13 mountain lions tracked by biologists via GPS collars. Park officials said two of the big cats were unaccounted for. Four monitored bobcats also were believed to have survived, but their habitats were burned, the park service said.While the damage was still being assessed, officials confirmed that Paramount Ranch's "Western Town," a landmark film location dating to 1927 that included a jail, hotel and saloon, burned to the ground. The TV shows "Westworld," ''The Mentalist" and "Dr. Quinn, Medicine Woman" were among the productions that shot there.Officials took the loss of the film location especially hard, because it was a unique feature among all the national parks."It's so special to share the story of moviemaking that came out of Southern California," recreation area spokeswoman Kate Kuykendall said. "We're the only National Park Service site that interprets American film history."There's been an outpouring of public support for rebuilding the site, she said, adding that at least three homes of park employees were gutted.The fire also destroyed much of nearby Peter Strauss Ranch, which hosted performances by Johnny Cash and Willie Nelson in the 1950s and more recently was a wedding destination.Jay-Rayon, 52, said customers at the sports nutrition store he owns were coming to terms with the fact that it could be months or longer before they can ride or hike in their favorite wilderness areas again.Also charred was Cheeseboro Canyon, former ranchland featuring trails through rolling grasslands against the backdrop of peaks and canyons. After winter and spring rains, the area is awash in green, but vegetation quickly dries in the persistent sun, fading to yellow and then brown. Grasses and other plants were brittle in the weeks before the fire started.U.S. Interior Secretary Ryan Zinke was touring the Woolsey burn area Thursday.About 15 percent of the Santa Monica Mountains National Recreation Area is National Park Service land. The remainder is made up of private property, California State Parks and other conservation lands.___Follow Weber at https://twitter.com/WeberCM___Associated Press journalist Brian Melley contributed to this report. 4138

LOS ANGELES (CNS) - As part of its stepped-up response to a surge in COVID-19 cases, California is tightening its requirements for face coverings, issuing revised rules that mandate everyone wear a mask at all times outside the home when within six feet of people from other households.The revised guidance issued Monday states that residents "must wear face coverings when they are outside the home," unless they are more than six feet away from other people.People who are outdoors but not close to anyone else do not have to wear a mask, but they must have one with them to put on in case they come within six feet of other people. The rules apply to anyone aged 2 or older, but exempt people with specific medical conditions and those who are hearing impaired or communicating with a hearing-impaired person.Other exemptions to the rule include:-- people in a car alone or with members of their own household-- people working alone in an office or room-- people who are "actively eating or drinking"-- workers who must wear respiratory protectionThe state has long called on residents to wear face coverings in public, particularly while in close contact with others. The new rules broaden previous guidance that provided recommendations on when people should wear masks.The state rule essentially mirrors the guidance in Los Angeles County, which says residents "should use a clean face covering anytime they will be in contact with other people who are not household members in public or private spaces." 1518

LOS ANGELES (AP) — The pork industry is challenging the constitutionality of a voter-approved California measure that will prohibit the sale of meat products from hogs born to sows confined in spaces that don’t meet new minimum size requirements.A lawsuit filed late Thursday in San Diego federal court by the National Pork Producers Council and the American Farm Bureau Federation targets Proposition 12, which voters overwhelmingly passed a year ago and goes into effect in 2022.“Proposition 12 has thrown a giant wrench into the workings of the interstate market in pork,” the filing states.The measure bans the sale in California of pork and veal from farm animals raised in conditions that don’t meet its standards. It also requires that all eggs sold in the state come from cage-free hens.The rules will apply to pork products coming to California from farmers nationwide, not just from in-state farms. The industry lawsuit contends that extraterritorial reach intrudes on authority given to Congress.”Plaintiffs seek a declaration that Proposition 12’s requirements with regard to breeding pigs violate the Commerce Clause and principles of interstate federalism embodied in the U.S. Constitution, and an injunction against the enforcement of Proposition 12’s requirements concerning pork,” the lawsuit states.The ballot measure, dubbed the Prevention of Cruelty to Farm Animals Act, was sponsored and financed by the Humane Society of the United States.The lawsuit was termed “frivolous” in a statement from Jonathan Lovvorn, the Humane Society’s senior vice president for animal protection litigation.“It’s an industry out-of-step with the preponderance of consumers who find animal abuse unacceptable, yet is still trying to hold on to archaic practices — like those banned by Prop 12 — that inflict an immense amount of pain and suffering on animals,” he said.Proposition 12′s requirements include giving breeding pigs at least 24 square feet (2.2 square meters) of floor space in group pens.It also bars the use of individual stalls that do not meet “stand-up, turn-around” requirements, except during brief periods prior to farrowing and during weaning.The lawsuit states that the measure’s requirements “are inconsistent with industry practices and standards, generations of producer experience, scientific research, and the standards set by other states.”It also imposes “enormous costs” on pork producers that will ultimately increase costs for consumers, it says.Before the election, the nonpartisan state Legislative Analyst’s Office said Proposition 12 would likely result in an increase in prices for eggs, pork and veal partly because farmers would have to remodel or build new housing for animals.It could also cost the state as much as million a year to enforce and millions of dollars more a year in lost tax revenues from farm businesses that choose to stop or reduce production because of higher costs, the office said.According to 2017 U.S. Department of Agriculture data cited in the lawsuit, nearly 65,000 farms nationwide sold hogs that year with a market value of more than billion. Pigs are raised nationwide, but production is concentrated in the Midwest and North Carolina.California’s pork consumption accounts for about 13 percent of the national market. But the state has only about 1,500 commercial breeding sows and needs the offspring of about 673,000 sows to satisfy its residents’ annual demand for pork meat, the lawsuit states. 3487

LOS ANGELES (KGTV) - A water main break created a sinkhole Friday, swallowing cars and flooding streets in South Los Angeles.The Los Angeles Department of Water and Power said a 24-inch cast iron water main broke around 5 a.m. near Towne Avenue and East 55th Street."We can't shut it down fast. On this shutoff, there's 12 valves involved. You just can't shut it down completely. You have to keep some water in the system. It's just a slow process," Eric Shavly from LADWP told KABC. "Whatever the cause, it could be corrosion, age - we don't know at this moment until we dig down and see the actual damage on the water main."A pickup truck that fell into the sinkhole also cracked a gas line, causing gas and water to be shut off to the area. 41 people were evacuated during the emergency, KABC reported.After four hours, crews gained control of the flow.The cause of the water main break was unclear. 910