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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) -- In anticipation of its members returning, 24 Hour Fitness locations around San Diego County have made several changes that will allow them to follow county health guidelines and keep their doors open.Under the state’s tiered system for businesses, 24 Hour Fitness is among those able to resume indoor operations, but with specific modifications in place.The fitness centers are now requiring reservations for 90-minute workout sessions, and each location can only operate at 10 percent capacity, so they have to keep a close eye on how many people are inside of the building.While reservations will not be required for clubs in San Diego County, each club in the county will be capped at a 10 percent capacity.Jeremy Franke, Regional Vice President of 24 Hour Fitness, said, “We have a check-in system where we can check at any time and know how many people are in the club. And when we reach capacity, our system flags and says we’re at capacity. And we’ll have the next person wait. Like retail stores, we let one in and one out if we get full.”Once inside the gym, social distancing is a must. There are signs and markers that remind members about staying six feet apart.24 Hour Fitness has also stepped up with cleaning and disinfecting, shutting everything down for 30-minute periods throughout the day to do so.Some things will remain closed, such as spas, saunas, pools, and basketball courts. Drinking fountains won’t be available either.Management also says each of their 25 locations in San Diego County will be very strict when it comes to enforcing wearing facial coverings.Right now, group classes are not yet available, but 24 Hour Fitness is working on bringing those back.Hours of operations have also changed temporarily, with clubs operating from 5 a.m.-9 p.m. 1806

SAN DIEGO (KGTV) -- Large churches throughout San Diego are scaling down services in an effort to control the spread of the novel coronavirus. Miles McPherson, Senior Pastor of The Rock Church, says they normally get 12 to 13 thousand people who attend services at their seven campuses. Now, attendees who show up for worship won’t be allowed inside. A message sent out to members let them know about the change. RELATED: What's the difference? Cold vs. Flu vs. Coronavirus Symptoms“All of our physical Rick Church campuses will be closed for the foreseeable future. However, we are still going to have church and it’s going to be awesome,” McPherson said. “Here’s what’s going to happen. On Sunday at our normal times – 8, 10, 12, and 6, we will be broadcasting all of our services online on all of our platforms,” he added. McPherson also said church staff are taking precautions for those inside by sanitizing surfaces and not shaking hands. RELATED: Districts across San Diego County closing schools amid coronavirus outbreakClick here to watch the live Sunday services. The Rock Church isn’t the only religious organization making changes amid COVID-19. The San Diego Catholic Diocese says, beginning Monday, all daily Masses will be cancelled, but they will be streaming Sunday Mass in English, Spanish and Vietnamese. The Diocese adds that churches will remain open for parishioners who want to pray and seek spiritual assistance. It’s unclear how long Mass will be cancelled. RELATED: What's been canceled, postponed in San Diego, nationally due to coronavirusClick here for more information, or to watch Mass online. 1634

SAN DIEGO (KGTV) - It’s a great time to buy a used car. “These deals are once in a lifetime,” said Ivan Drury, a used car expert with Edmunds. Amid the uncertainty caused by the coronavirus pandemic, used car prices have been decreasing. According to Bloomberg News, the average price of a used car fell 11.4% from March to April. Drury predicts those prices could continue to fall, as desperate rental car companies start to offload unused inventory. Hertz, which filed for bankruptcy on Friday, has a fleet of about 500,000 vehicles. It’s unclear what their plan is for them, but Drury suspects they will only keep enough to maintain a basic level of service. “That influx of used vehicles will have a dramatic impact on price,” he said. Adding to the supply of used cars, Drury predicts that some drivers who have leased cars will hold on to them for a few more months rather than trade them in. But in several months to a year, he expects that could lead to another flood of used vehicles. “You kind of have a perfect storm for used car values to drop even further,” said Drury. 1090

SAN DIEGO (KGTV) -- It’s almost time to welcome back the nail-biting excitement of the Scripps National Spelling Bee.This year’s countywide bee will be held on March 15 at the McMillin Companies Event Center at Liberty Station.Roughly 100 spellers are expected to take the stage, making competition fierce.Last year was an exciting year for the competition as it saw its youngest speller ever, Edith Fuller of Oklahoma, who was only 5-years-old when she qualified.Fuller went all the way to the national stage. The spelling bee has been around for more than nine decades.The bee was founded in 1925 and has been held every year since, except during the World War II years of 1943, 1944 and 1945.In 2017, the competition celebrated its 90th National Spelling Bee.2017’s winning word was marocain, which is “a ribbed crepe fabric used in women's clothing.”The Scripps National Spelling Bee will begin May 29 and end on May 31.  943

来源：资阳报