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SINGAPORE – There would be "significant improvement across the board" if countries were led by women, former President Barack Obama said, 151

A lockdown has been lifted at Pearl Harbor Naval shipyard after a US sailor fatally shot two people and injured another before killing himself Wednesday, an incident for which officials do not yet have a motive.The shooter's name has not been released, but he has tentatively been identified as an active-duty US sailor assigned to the USS Columbia, a submarine that is in dry dock at the base for standard maintenance work, said Rear Adm. Robert Chadwick, commander of Navy Region Hawaii."We are saddened by this incident, & our thoughts & prayers are with the victims & their families," Chadwick said on the verified Twitter account of the 666

The opioid crisis has had a devastating impact across the country.Now, doctors in one state are tackling the problem head on, and it starts with how they treat pain in the emergency room. When Dr. Donald Stader walks through his emergency room these days, it's almost like he's a different doctor. “I used to over prescribe opioids for the first several years of my career and residency,” he says. “I was giving them out like Tic Tacs, if you will.” All that changed a few years ago, when he met a woman overdosing on heroin. “She told me that she actually got hooked after being prescribed Percocet for an ankle sprain,” Dr. Stader says. “And one thing that struck me, earlier that day I had prescribed Percocet for an ankle sprain and thought that I was practicing really good medicine.” Now, he and his hospital, Swedish Medical Center, are a part of the Colorado Hospital Association’s ALTO Project, a program aiming to reduce the use of opioids in emergency rooms in the state, using alternative pain treatment.The program is paying off.However, experts say it's too late. The crisis is so bad, so simply improving prescription practices is not enough to combat opioid abuse. In an article published in JAMA Psychiatry, doctors say in addition to tighter drug restrictions, psychiatrists specializing in depression and suicide, along with new research and treatments, are needed. Now, they treat patients with medications like Tylenol and ibuprofen. For stronger pain, they use ketamine, bentyl and lidocaine, which is often used in the dentist’s office. Two million Americans struggle with opioid addiction and 42,000 people died of overdoses in 2016 alone. 1678

The drug ketamine is used as an anesthetic, a pain reliever or even a club drug. But now, a ketamine-like drug could soon be approved by the FDA to help people fighting severe depression. Sally Owens is one patient undergoing ketamine treatment. “You feel secure in and grounded, even though you're in a dream state,” Owens says of the treatment. “And in an hour, you come out of it and you're feeling better.” The retired nurse started getting IV ketamine treatments after fighting depression with antidepressants for most of her adult life, with no success. But after two sessions at Vitalitas, a Denver ketamine infusion center, she saw results. “I was doing more things around the house and getting out and and doing more things with friends,” she says. Owens says she’s excited to hear the FDA is considering a more accessible, less potent nasal spray similar to ketamine. “You could essentially think of esketamine as half of ketamine,” describes Dr. Roman Langston, who treats patients with ketamine. Esketamine would be for people with severe depression who haven't benefited from at least two different therapies, the doctor says. 300 million people around the world are affected by severe depression. Drug makers hope the spray can help 30 to 40 percent of patients, who don't respond to antidepressants. Antidepressants can take weeks to take effect, while they say nasal spray benefits start after four hours. Dr. Langston says FDA approval could make more people comfortable using the drug, commonly known as a party drug. Right now, it's not covered by insurance. Sessions can range from 0 to 0 for a session. “If they qualify for coverage through their insurance company, maybe it's a copay, and they can give it a try and it could make a huge difference in their life,” he says.Dr. Langston says it remains to be seen what the long-term consequences of esketamine are. 1907

A construction worker was killed while working on Disneyland property in Anaheim, California, early Thursday, police said.The 38-year-old man was working for a contractor for the park when he became pinned under a large metal plate in a trench, Anaheim Police Sgt. Daron Wyatt said.The worker was installing a large pipe when "construction equipment struck a crossbeam, dislodged the plate, which fell and struck him," Wyatt said.Anaheim Fire and Rescue were able to rescue him from the trench, but he was pronounced dead at the scene."We are saddened by this tragic accident involving a contractor and on behalf of Disneyland Resort extend our deepest sympathies to this gentleman's family, friends and coworkers," said Liz Jaeger, Disneyland Resort spokeswoman. 775