汉中补习机构实力升学率(铜川高一复读效果好) (今日更新中)

SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) - The cost of living in San Diego doesn’t always make it easy for local families to take vacations. Hotels and home rentals can drain a family’s savings. 10News reporter Jennifer Kastner found a local family that’s able to go jet setting without breaking the bank, thanks to a home exchange network.Dana Fallentine, her husband, and their four kids have been taking incredible vacations at an impressive savings. “[We’re talking] thousands and thousands and thousands of dollars,” she tells 10News. Fallentine found the website Love Home Swap, which connects users with homeowners around the world. Arrangements can be made to do temporary home trades.The fee is 0 a year. Compare that to the most recent average U.S. hotel price, which is 0 a night, according to Statistica. Members can swap homes or use points to stay in rental homes. Type in where you want to go and when. Browse the options to see photos and amenities, and then start chatting with the owner. For privacy and security, Love Home Swap does ID verification. For protection, phone numbers, email addresses and home addresses are not made visible on the website.The Fallentine family's most memorable experience was from a swap they did with an Italian family. The Italians got to the Fallentine's home the night before the Fallentine's flew off to the Italians' home in Rome.“I took them to Costco. They bought all this food and then they said, ‘Oh, we're going make you guys dinner.’ I’m like, ‘Totally! I’m not going to pass up a meal by real Italians. I mean, that's crazy!’”Fallentine says when her own family home-swaps, having access to another home’s kitchen is one of the biggest cost-savers.“If you're thinking about the food aspect, just to be able to cook your own food is amazing and [you have a] full kitchen with everything you need,” she adds.Another perk is having access to a home's laundry room. It allows the Fallentines to save on airline baggage fees, because now they can carry-on backpacks and wash their clothes at the vacation homes. For a family wanting to live large on a small budget, she says Love Home Swap has been a game changer. “It saves money. It’s just common sense, basically,” says Dana. 2235

SAN DIEGO (KGTV) -- Taco Tuesday is a serious ritual, especially in San Diego.  This week, you're getting another reason to eat Mexican food (not that you needed an excuse). Thursday, April 5 is National Burrito Day! On Tuesday we asked 10News?Instagram followers where to find some of the best burritos in the county. If you came here looking for food chains offering deals, scroll down! Here are the best burritos, according to our Instagram followers:  483

SAN DIEGO (KGTV) -- The California Department of Public Health made a quiet announcement late Monday night that could be a welcoming relief for families all over the state looking for outdoor activities amid the pandemic.Health officials are allowing counties to reopen outdoor playgrounds located in parks, campgrounds, and other publicly accessible locations.But guidance is firm and strict as the state continues to battle the deadly coronavirus pandemic."COVID-19 continues to pose a severe risk to communities and requires all people in California to follow necessary precautions and to adapt the way they live and function in light of this ongoing risk," state health officials said.At the top of the list of requirements is the rule on face coverings. "Face masks over the mouth and nose are required for everyone 2 years of age or older with caregiver supervision at all times to ensure face mask use," officials said.Other rules include a 30-minute limit on visits when others are present, no eating or drinking in playgrounds, and elderly persons and others with underlying medical conditions should avoid playground when others are present."This guidance does not apply to indoor playgrounds or family entertainment centers," the state said.San Diego County has not yet issued a timeline for when the caution tape wrapped around local playgrounds since March will finally come down.Last Tuesday, a group of two dozen state lawmakers sent a letter to Governor Gavin Newsom asking him to create clear guidelines for reopening. San Diego Mayor Kevin Faulconer tweeted his support for the letter.A recent report from the American Academy of Pediatrics reinforced guidelines that say kids 3-5 years old should get three hours of physical activity every day. Kids 6-17 need at least one hour.Doctors, however, still urge caution."Playgrounds are gold mines for transmissions for other diseases," says Dr. Christian Ramers, an Infectious Disease Specialist at Family Health Centers of San Diego."Kids get runny noses. There's a lot of touching there. Kids are touching everything with their hands. So I think there's uncertainty."READ STATE GUIDANCE BELOWOutdoor Playground Definition:Fully outdoorsPublicly accessibleFree to enter and useOperated by a city, state, county, or federal governmentDesigned primarily to serve nearby residents within a half a mileCan provide State-mandated outdoor space for preschools (which could be scheduled in advance to avoid overlapping use)Typically includes recreational equipment, like play structures, slides, swings, etc. intended to enrich children's physical health and developmentVisitors to outdoor community playgrounds must comply with the following requirements:1. Face masks over the mouth and nose are required for everyone 2 years of age or older with caregiver supervision at all times to ensure face mask use2. Do not use the playground when different households are unable to maintain a physical distance of 6 feet or when the capacity limit of [number of children and number of adults] has been reached3. Caregivers must monitor to keep adults and children from different households at least 6 feet apart4. Consider coming on different times or days to avoid wait times and potential crowded times5. No eating or drinking in playground, to ensure face masks are worn at all times6. Wash or sanitize hands before and after using the playground.7. Elderly and persons with underlying medical conditions should avoid playground when others are present8. Limit visit to 30 min per day when others are presentNote: Facility operators should download and print this flyer to post at all outdoor playgrounds.All playground facilities operators should review and follow these recommendations:1. An adult must actively supervise each child at all times to make sure that children two years of age or older keep their face covering over their nose and mouth and stay 6 feet away from adults and children outside their household.a. Children who are supervised by the same adult must stay together in the same play area or play structure at all times, to allow active supervision.b. If an infant or child requires attention (nursing, diapering) that precludes an adult from actively supervising other children using the playground, the adult should ask the other children to leave the play structure/area and stay by the adult's side until needed care is complete.2. People standing outside the playground, including people waiting to enter the playground, should remain 6 feet away from areas of the playground used by children and adults.3. Maintain six-foot distancing between children and adults from different households including children using or waiting to use play structures or play areas, and families waiting to enter the playground.4. Increase cleaning of frequently touched surfaces, daily as practicable.5. To the extent feasible, provide handwashing stations or sanitizer to facilitate hand hygiene, especially during times of heavy usage. Use a hand sanitizer containing (60% ethanol or 70% isopropanol). Never use hand sanitizers with methanol due to its high toxicity to both children and adults.6. Post the maximum number of children allowed at the entrance of each playground.a. Determine and post the maximum occupancy of each play structure, (e.g., climbing structures, slides, swings, spinning structures, and sand areas) with 6 foot vertical and horizontal distancing.b. Determine and post the maximum occupancy for supervising adults to ensure that each adult can maintain six feet of distance from other adults and children.c. Provide directions on how to wait in line when maximum playground occupancy has been reached.7. Mark playgrounds to help children and adults maintain 6 foot distancing.a. Mark spaces for families to stand while waiting to enter the playground. The spaces should be far enough apart to allow 6 feet of distance between households.b. For play structures or play areas that can hold more than one child while allowing 6 foot distancing:i. Post the maximum number of children allowed on each structure/in each area to allow 6 foot distancing vertically and horizontally.ii. For play structures or areas that can hold more than 1 child, consider marking with tape or other visual indicators to help children assess whether they are 6 feet apart.c. Mark designated spaces 6 feet apart for children to stand while waiting to use a play structure/area.Additional ConsiderationsIf there is a pre-scheduled activity that will access the playground, the playground must be closed to the broader public during that time.Child care programs, schools, out-of-school time programs and other programs for children and youth where children must remain in cohorts may not use playgrounds during times when they are open to the public. However, if the playground operator permits, the childcare, school or other program may reserve a time for the exclusive use of the playground by the program. While on the playground, cohorts should maintain separation and avoid mixing. 7063

SAN DIEGO (KGTV) – The affidavit accusing San Diego County Congressman Duncan Hunter and his wife, Margaret, of prohibited use of campaign contributions, provides shocking details about how the couple allegedly spent the money and covered it up.The grand jury's indictment accused Hunter and his wife of misusing campaign funds on everything from vacations to tequila shots at a restaurant.The affidavit says the Hunters made purchases with campaign funds including more than ,000 for a family trip to Italy, more than ,300 for purchases at Costco, and more than ,000 for airline tickets and hotel rooms for their family and friends.GALLERY: Alleged instances of campaign fund misuse in Hunter affidavitNumerous alleged charges also cover amounts in the hundreds at grocery and retail stores and restaurants, including one charge in 2015 at Disneyland totaling 9.44 for Minnie Mouse Ear headbands and apparel, and another in 2016 for "30 tequila shots and one steak" totaling 2.46 at a restaurant.Charges listed in the affidavit span from San Diego County locales to Washington, D.C."The Hunters illegally converted and stole more than 0,000 in campaign funds to purchase goods and services for their personal use and enjoyment," the affidavit reads. "The Hunters disregarded rules implement by the Treasurer to track legitimate expenses ... and, when pressed by the Treasurer to comply, dismissed the rules as 'silly.'"RELATED: Congressman Duncan Hunter and wife indicted for campaign fund misuseHunter has repeatedly denied any wrongdoing or campaign fund misuse. Tuesday, he categorized the indictment as a "politically motivated" attack."We’re excited about going to trial with this, frankly," Hunter said of the indictment. "This is modern politics and modern media mixed in with law enforcement that has a political agenda. That’s the new Department of Justice."The affidavit says the Hunters overdrew their bank account more than 1,100 times, resulting in bank overdraft fees of about ,761.RELATED: San Diego Congressman Duncan Hunter addresses federal indictment in 10News interviewAs the U.S. Representative for District 50, Hunter has an annual salary of 4,000, according to ballotpedia.org. 2283

来源：资阳报