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SINGAPORE, Sept. 7 (Xinhua) -- Singapore scientists have found possible new ways to treat a type of aggressive breast cancer that is unresponsive to current forms of treatment, local broadcaster Channel NewsAsia reported on Wednesday.The team of scientists at the Genome Institute of Singapore ( GIS) and National University of Singapore (NUS), led by GIS senior group leader Qiang Yu, found that the enzyme EZH2 acts by inhibiting genes that stop the growth of tumors in the body.The insights could open the door to developing more effective treatment for fast spreading breast cancers, especially the estrogen receptor-negative breast cancer that is common all over the world.It was also found that through EZH2, cancer is promoted in the body by activating specific genes that impact breast cancer progression and cancer stem cell self-renewal.Yu said the new understanding on how EZH2 works as a cancer- causing gene in breast cancer has important therapeutic implication."The results suggest that small molecule drugs that block enzyme activity of EZH2 may not work for cancers caused by EZH2's activation genes," Yu said.Currently pharmaceutical companies have been developing drugs only to the block EZH2 enzyme activity so that tumor suppressers can perform their protective role in blocking cancer growth.Researchers said the next step would be to develop biomarkers to identify tumors with EZH2.This step would enable better treatment methods, with one of options being the development of therapies that shut down EZH2 completely and not just inhibit its enzymatic function.The findings have been published on the journal Molecular Cell.

BEIJING, July 26 (Xinhuanet) -- Seven of the 20 top selling American prescription drugs will lose their patents by the end of next year, making way for less expensive generic versions, according to media reports.It's a shift that could save consumers billions of dollars -- assuming those big-ticket medications are willing to give up a trusted brand name for an off-label replacement.The prices of medications such as cholesterol-fighting Lipitor and blood thinner Plavix are expected to go down significantly, according to the U.S. Food and Drug Administration (FDA).Lipitor will lose its patent in November. When that patent expires, people are advised to buy atorvastatin, the generic equivalent. Other brand names include the anti-psychotic Zyprexa and the rheumatoid arthritis and psoriasis drug Enbrel, of which the patent will expire in October and October of next year, respectively.Over the next 10 years, an estimated 120 more brand-name prescription drugs will lose their patents in the U.S.

RIO DE JANEIRO, Aug. 31 (Xinhua) -- The Brazilian city of Rio de Janeiroe may have an unprecedented dengue fever epidemic next summer, its mayor warned on Wednesday.The increasing number of dengue fever cases in the past few months shows similarities to the months predecing the 2002 and 2008 epidemics, Mayor Eduardo Paes said."Everything points to a new cycle of the disease, certainly the worst epidemic in Rio's history," he said.In 2008, Rio registered some 250,000 cases of dengue fever, with 174 people confirmed dead from the disease. In 2002, Rio had some 290,000 dengue fever cases and 91 people died.In efforts to halt the spread of the disease, Paes has declared a state of alert and is determined to take a series of measures to eliminate the habitat of the Aedes aegypti mosquito, which transmits dengue fever through its bite.Paes also announced an increase in the number of health care units for dengue fever patients. The total cost of a dengue prevention and combat program, which is expected to last until April 2012, will reach 42 million reais (26.25 million U.S. dollars).There is no vaccine against dengue fever, but Brazilian scientists are currently working on one which will immunize against four types of the disease.

DAMASCUS, Sept. 21 (Xinhua) -- The national archeological expedition recently discovered a gigantic building built with large-size hewn stones that date back to the Roman era, Syrian Arab News Agency (SANA) said Wednesday.The building, the thickness of its walls up to 1.5 meters, was found at Qumet Nibal site in the northeastern province of Raqqa, said SANA.Ibrahim Kheir Bek, head of the archeological department in the area, told SANA that the excavation unearthed a 6-meter-long entrance to the building, adding that works are still underway in the site.A day earlier, the national archeological expedition discovered a mosaic dating back to the 6th century A.D. in northeast Syria, SANA said, adding that the rectangular mosaic was found at Hwaija Halawa site on the banks of al-Assad Lake in Raqqa province.Ayham al-Fakhri, head of the national expedition, was quoted by SANA as saying that the expedition uncovered 58 square meters of the mosaic with various colorful geometric shapes.

CANBERRA, Aug. 17 (Xinhua) -- Australian scientist on Wednesday said his international research team has discovered the trick on how butterfly learn to change its wing pattern to avoid being eaten by birds.The Amazonian butterfly, Heliconius numata, has learnt to carry out a single genetic switch to alter its wing pattern so it appears to be another bad-tasting butterfly that birds will avoid.Dr. Siu Fai (Ronald) Lee from the Department of Genetics and Bio21 Institute at Australia's University of Melbourne was part of the international research team, which was led by scientists at Centre National de la Recherche Scientifique (CNRS) and the University of Exeter in United Kingdom.Dr. Lee said the historical mystery had puzzled researchers for decades."Charles Darwin was puzzled by how butterflies evolved such similar patterns of warning coloration," Dr. Siu Fai (Ronald) Lee from the Department of Genetics and Bio21 Institute at the University of Melbourne told Western Australia Today."We have now solved this mystery, identifying the region of chromosome responsible for changing wing pattern."He said the research team identified a genetic switch known as a supergene, which allowed the butterfly to morph into several different forms, allowing one species to mimic another."It is amazing that by changing just one small region of the chromosomes, the butterfly is able to fool its predators by mimicking a range of different butterflies that taste bad," he said."The butterflies rearrange this supergene DNA like a small pack of cards, and the result is new wing patterns. It means that butterflies look completely different but have the same DNA."There are other butterflies doing similar tricks, but this is the most elegant one."I was just fascinated by how elegant they were."He said the discovery proves that small chromosomal changes can preserve successful gene combinations, and thus help a species to adapt.The findings of the study are published on August 14 in the international journal Nature.

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