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Hours after a chaotic presidential debate, Democratic presidential nominee Joe Biden embarked on a train tour through northeast Ohio and western Pennsylvania on Wednesday.Biden made seven stops in towns and cities throughout the region. He delivered an address in Cleveland at about 10 a.m. ET upon his departure and his tour concluded in Greensburg, Pennsylvania, east of Pittsburgh.During several terms as a Delaware senator and throughout his time as Vice President, Biden became known for commuting back and forth between Washington and his home in Wilmington, Delaware via an Amtrak train, earning him the nickname "Amtrak Joe."On Tuesday evening, Biden and President Donald Trump traded political barbs and personal insults in a messy presidential debate. Trump often interrupted both Biden and moderator Chris Wallace, preventing either candidate from fully expressing their campaign positions.Recent national polls show Biden still holds a lead over Trump a month out from the election. However, Biden will need a strong showing in Pennsylvania — a state that went to Trump in the 2016 election. Polls show that Biden has a small lead in the Keystone State and that Ohio is currently a toss-up race. 1215
Genetic testing company 23andMe has been given federal approval to sell at-home kits that test for three breast cancer gene mutations.This will be the first direct-to-consumer DNA test for these particular breast cancer gene mutations, the Food and Drug Administration said on Tuesday.A spokeswoman for 23andMe said the test for the three BRCA1/BRCA2 breast cancer gene mutations will be added "in the coming weeks" to the broader Health + Ancestry services, with no increase to the existing 9 cost.The test can only detect three out of more than 1,000 known BRCA mutations, according to the FDA. The BRCA1/BRCA2 hereditary mutations occur in about 2% of Ashkenazi Jewish women, but rarely occur in anyone else, the agency said in a press release."The test also does not provide information on a person's overall risk of developing any type of cancer," the FDA added.23sandMe already tests for genetic health risks for diseases like Parkinson's and Alzheimer's, along with wellness reports for things like lactose intolerance and saturated fat, and ancestral composition including Neanderthal ancestry.In 2013, the FDA ordered the company to stop sales of its home-testing kits, saying the Alphabet-backed company had failed to prove the validity of its product.Related: 23andMe gets funding for drug developmentAnne Wojcicki, who founded the company in 2006, called the FDA shutdown a "transformative moment" that prompted 23andMe to branch into drug development."Thank you to the FDA for hard work and progress on innovation," she tweeted on Tuesday.In 2015, 23andMe received approval from the FDA to test customers for whether they are carriers of certain disease-carrying genes that could be passed on to their children. In early 2017, the company received approval to issue genetic health risk reports.In September of last year, the company said it received 0 million in funding from Sequoia Capital to develop drugs based on user DNA.The-CNN-Wire? & ? 2018 Cable News Network, Inc., a Time Warner Company. All rights reserved. 2050

Historic numbers of background checks to purchase or possess a firearm have been conducted in June. It's just the latest month with record-breaking numbers since the system was created in 1998. The FBI reported Wednesday that 3.9 million checks were done last month in what's a key barometer of gun sales. The numbers are driven by the crises that have roiled the U.S., including the coronavirus pandemic, an economic recession, protests over racial injustice and calls to reduce police funding. A group representing gunmakers says firearm purchases are a reasonable reaction to the political climate, while gun control advocates say they're concerned first-time buyers don't have enough training. 705
HAWAII (KGTV) -- As more evacuations loom in Hawaii, San Diegans are working to help those already in shelters on the Big Island. 143
Happening now: a new eruption of Kīlauea inside Halema?uma?uSee live webcams inside Halema?uma?u, courtesy of USGS Hawaiian Volcano Observatory: https://t.co/Yf1Kc3AeJ9 pic.twitter.com/bsNmt3ZTUg— Hawaii Volcanoes NPS (@Volcanoes_NPS) December 21, 2020 266
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