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This is a battle that could shutter some classrooms indefinitely.Hundreds of Oklahoma teachers filled the state Capitol for a second day Tuesday, demanding an additional 0 million in school funding and increased raises for themselves and support staff.Their walkout comes days after the state approved some raises and school funding -- but only a fraction of what the teachers' union demanded.So despite school cancellations and even the risk of discipline from some districts, teachers say they won't budge."We will hold the line until hell freezes over, and then we will be here on ice skates," Muskogee High School teacher Diane Walker said. "We love our kids." 675

Today our office issued a letter to Kanye West informing him of the insufficiency of his independent candidate nomination petition for President. The petition was determined to have 6,557 valid signatures of the required 10,000. pic.twitter.com/vxOSk8WCD3— Missouri SOS Office (@MissouriSOS) August 25, 2020 315

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

They've been ignored for decades, but now, drive-in movie theaters are making a huge comeback. It's the only place where large crowds of people can see a movie together, and still maintain a social distance.Usually on vacant lots or in rural areas, the drive-in was hugely popular. Until it wasn't. Fancy theaters took over and many of those sites became a piece of history, the empty lots they sat on often doubling as a swap meet.“It’s been one of the most interesting stories of the pandemic, in terms of the movie business, is that drive-ins, which have been mostly ignored since the 70s and 80s, have become the focal point for theatrical movie going and for people who want to get out of the house and go to the movies, because those are the spaces that are open and I think it will have an impact going forward,” said Ross Melnick, professor of film and media studies at the University of California Santa Barbara.Melnick is also the man behind the website Cinema Treasures. The site provides research on more than 50,000 theaters around the world. “It features memories, comments, data, photographs; it’s a globally crowd-sourced information database in which people can talk about when they worked at theaters, the information they have on them. as well as remembering their history and contemporary function,” he explained.Now, it's a social site. People keeping in touch, remembering their favorite theaters, and their favorite memories. “When you’re home, you’re thinking about what you’re missing, what you used to do--used to go to the restaurant, coffee shop and one of the things they used to do is go to the movies,” Melnick said.The Memphis-based Malco Theatres has been a family business since 1915. There are 36 locations and one drive-in, which recently reopened. Malco called it a "socially distant cinematic success."“It’s selling out. It’s like the glory days,” said David Tashie, president of Malco Theatres. “Cars are piling in. The food is different, there’s walk-up tents and we’re bringing the food, so it’s definitely making a surge, and hopefully it continues when the indoor theaters open."The "glory days" as shown from this newspaper clipping on the cinema treasures site. Malco Theatres have been through a lot through the decades, having to adapt to every technological evolution. “We were the first to integrate theatres,” said Tashie. “We’ve survived Spanish flu, wars.”And now, they've survived a pandemic. “There’s a lot of history here we’re trying to protect and we’re on it, and Hollywood needs to keep delivering movies and we’ll have great places to show them,” he said.The Summer Drive-in is not alone. Melnick says there's been pop-up drive-ins all over the country and world. Some are so full they're turning people away. It's the one place where people can be together, even if they're not. "The longevity of the kind of business it creates a stake in the community there’s this continuum you have this place that and multiple generations have grown up in the area,” Melnick said. “The summer drive-in is this consistent location for rites of passage- childhood, teenage hood or parenthood. You have this consistency.” 3175

This flight attendant gives an emotional farewell to passengers, crew on her final flight. https://t.co/Nbj9wt0knR pic.twitter.com/6wn3GB2S6s— Good Morning America (@GMA) October 4, 2020 194

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