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The 2019 Nobel Prize for Medicine has been jointly awarded to William Kaelin Jr., Sir Peter Ratcliffe and Gregg Semenza for their pioneering research into how human cells respond to changing oxygen levels.Announcing the prize at the Karolinska Institute in Stockholm on Monday, the Nobel committee said that the trio's discoveries have paved the way for "promising new strategies to fight anaemia, cancer and many other diseases."The 2019 medicine laureates, the committee added, have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.The importance of oxygen has long been established, the committee explained, but how cells adapt to changes in its levels remained unknown.Randall Johnson, prize committee member, described the trio's work as a "textbook discovery.""This is something basic biology students will be learning about when they study, at aged 12 or 13, or younger, biology and learn the fundamental ways cells work. This is a basic aspect of how a cell works and, from that standpoint alone, it's a very exciting thing."The winnersNew York-born Kaelin established his own research laboratory at the Dana-Farber Cancer Institute in Boston and became a full professor at Harvard Medical School in 2002.Semenza, also born in New York, became a full-time professor at Johns Hopkins University in 1999 and since 2003 has been the Director of the Vascular Research Program at the Johns Hopkins Institute for Cell Engineering.Ratcliffe, who was born in Lancashire, England, studied medicine at Cambridge University and established an independent research group at Oxford University, becoming a full professor in 1996. 1694

The immigrants were shouting “Three million deportations” at Joe Biden because they are running a campaign to get candidates to commit to reunifying the record number of families deported under the Obama - Biden administration. 240

Thanks to social media and the help of people in Georgia – police say two dine and dashers have been caught – and claim they’ll make it right.“It breaks your heart,” said Lisa Ritter, the manager at Big Daddy’s Oyster Bar and Pub in Peachtree City, Georgia.Ritter says two people came in days before Christmas, spent hours at a table, racked up a huge tab, then took off.“If you can’t afford to go out and eat, it’s bad enough you don’t get tipped well enough, waitresses only make .13 an hour, and it’s really bad that they dine and dash,” Ritter added.She says this isn’t the first time this has happened, and it probably won’t be the last…but says it really hurts business.“We have to still pay for it,” Ritter said.Peachtree City police say the bill was more than 0, and they asked the community for help identifying the dine and dashers.“After we posted some photos on Facebook, we received an overwhelming response from numerous people providing identification information,” said Lt. Matthew Myers with the Peachtree City Police Department.Lt. Myers says they have been in contact with the alleged thieves and adds that you can face many criminal charges if you walk out on a bill.He also says it’s not uncommon for establishments to make the server foot the bill.“There are instances where the waitresses have to pay for it, because if you’re not checking on your tables, if you’re horsing around, I could see that happening,” added Ritter.This time, they didn’t make the waitress pay, but Ritter says the waitress was still stiffed.“She was very upset and crying,” Ritter said, “They had been here for like four hours, that’s her tip…that would have been like a tip.”Police say the dashers have contacted Big Daddy’s and offered to make it right.That is yet to be finalized. 1803

The Massachusetts Institute of Technology is reviewing about 0,000 it received from foundations controlled by accused sex trafficker Jeffrey Epstein, MIT's president said.The school also will donate that amount to a charity benefiting Epstein's victims or other sexual abuse victims, President L. Rafael Reif said in an email.The review will focus on the facts around the donations, made over 20 years, and how the school handles contributions and can improve that process, Reif said.Epstein was awaiting trial on charges of sex trafficking involving underage girls when he killed himself by hanging in a New York jail cell this month."I offer a profound and humble apology" to the victims on behalf of the administration, Reif said. "With hindsight, we recognize with shame and distress that we allowed MIT to contribute to the elevation of his reputation, which in turn served to distract from his horrifying acts. No apology can undo that."The donations went to the MIT Media Lab or Seth Lloyd, a professor of mechanical engineering, according to Reif's email. 1078

The deadly heat wave that has blanketed much of the US is in its final day.A cold front moving through the Midwest will reach the East Coast by Monday, bringing heavy rain and cooler air, according to CNN Meteorologist Ivan Cabrera.The front will quiet days of extreme temperatures, Cabrera said.This week's high temperatures prompted cities across the US to open cooling centers, issue safety instructions to residents and cancel many outdoor events. New York's mayor declared an emergency. One death has been attributed to the high temperatures: Former NFL player Mitch Petrus, 32, died of a heat stroke after working outside Thursday during a heat advisory in Arkansas, officials said.Part of the relief comes from the dropping of overnight temperatures in the Midwest, which had often hovered near 80 degrees in the past week.While temperatures on the East Coast and Midwest may sink down to the 70s on Monday, Sunday still has some heat in store.Sunday severe weatherAlthough down from Saturday's 157 million, there are still more than 95 million people under a heat warning or advisory for Sunday.The heat index has much of the Midwest feeling as if it's in the 90s, while the East Coast faces triple digits -- with Washington, D.C., at the highest with 110.And although the more central states are being cooled a bit by the moving front, at least 350,000 people are without power across Michigan due to severe weather, according to 1451