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WASHINGTON, June 16 (Xinhua) -- Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage. New research by a team of scientists at the University of Rochester has unveiled an important new mechanism that allows cells to recognize when they are under stress and prime the DNA repair machinery to respond to the threat of damage.Their findings will be published Friday in journal Science. Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage.The scientists, led by biologists Vera Gorbunova and Andrei Seluanov, focused on the most dangerous type of DNA damage -- double strand breaks. Unrepaired, this type of damage can lead to premature aging and cancer. They studied how oxidative stress affects efficiency of DNA repair. Oxidative stress occurs when the body is unable to neutralize the highly-reactive molecules, which are typically produced during routine cellular activities.The research team found that human cells undergoing oxidative stress synthesized more of a protein called SIRT6. By increasing SIRT6 levels, cells were able to stimulate their ability to repair double strand breaks. When the cells were treated with a drug that inactivated SIRT6, DNA repair came to a halt, thus confirming the role of SIRT6 in DNA repair. Gorbunova notes that the SIRT6 protein is structurally related to another protein, SIR2, which has been shown to extend lifespan in multiple model organisms."SIRT6 also affects DNA repair when there is no oxidative stress," explains Gorbunova. "It's just that the effect is magnified when the cells are challenged with even small amounts of oxidative stress."SIRT6 allows the cells to be economical with their resources, priming the repair enzymes only when there is damage that needs to be repaired. Thus SIRT6 may be a master regulator that coordinates stress and DNA repair activities, according to Gorbunova.
HELSINKI, July 4 (Xinhua) -- A new Finnish research shows that sleeplessness may be hereditary, and insomniacs are more likely to die earlier than people with healthy sleep patterns.The research is the first to link insomnia with mortality risk, Finnish media reported on Monday.The research is conducted by the Institute of Occupational Health in collaboration with the University of Helsinki and the Finnish National Institute for Health and WelfareIn a large-scale twin study, the Finnish researchers followed the health status of 12,500 adult twin pairs during the years from 1990 to 2009. Twenty percent of the participants were suffering from sleeplessness symptoms, including difficulty in initiating sleep, nocturnal awakening and non-restorative sleep.The study found out that compared with unidentical twins, identical twins were more likely to suffer from similar insomnia symptoms. This finding indicates that genetic factors play a role in the formation of insomnia.Moreover, the participants were divided into three groups, according to their sleep qualities. Out of the participants, 48 percent were good sleepers, 40 percent average sleepers and 12 percent poor sleepers. The search result shows that insomnia-related symptoms may increase mortality risk.In addition, compared with good sleepers, 7 percent of the women and 22 percent of the men who were average sleepers were more likely to die earlier; and poor sleepers were 1.5 times more likely to die earlier.According to the researchers, sleeplessness is a common health problem among working-age cohort. Chronic sleeplessness raises the risk of many illnesses and accidents, and thus weakens people's quality of life and ability to operate properly.The experts suggest that insomniacs should seek medical treatment in time, and chronic insomnia patients should be better treated with non-drug therapy.
SAN FRANCISCO, June 9 (Xinhua) -- Hewlett-Packard Co. (HP) on Thursday announced that its tablet computer, HP TouchPad, will go on sale in the United States on July 1.Two versions of HP TouchPad, with the option of either 16 gigabytes or 32 gigabytes of internal storage, and both only with Wi-Fi connection, will be available in the United States for 499. 99 U.S. dollars and 599.99 dollars respectively, the company said in a statement.The product will hit stores in Britain, Ireland, France and Germany a few days later and in Canada in mid-July, with availability scheduled to follow later this year in Italy, Spain, Australia, China's Hong Kong, New Zealand and Singapore.Preorders in North America and Europe will begin on June 19, HP said.HP did not release the price details when it introduced TouchPad on Feb. 9. The black device, with a 9.7-inch touch screen, runs webOS operating system, a mobile platform developed by Palm, a smartphone maker acquired by HP last April for 1.8 billion dollars.
BEIJING, Aug. 24 (Xinhua) -- China will prioritize the development of six types of new materials in its new material industry over the next five years, the China Securities Journal said on Wednesday.The report cited an insider, who noted that the country's 12th Five-Year Plan (2011-2015) for the new material industry will come out in September, in which the government will launch key projects to support the development of the six materials.The six materials will be high-strength light alloy, advanced iron and steel, carbon fiber composite, new power battery material, function coated material, and rare earth function material, according to the report.The plan states each of the six sub industries will form a sizable industrial scale, with the industry's total output value to hit trillions of yuan by the end of 2015, and the self-supply rate to reach 70 percent during the period, the report said.Meanwhile, the government will also foster the development of materials in sectors such as green building material and the biomedical industry over the next five years, it added.
SAN FRANCISCO, June 28 (Xinhua) -- Google has launched a new site wdyl.com, a search service standing for "what do you love" and integrating a variety of Google's search products on one page.According to a report by technology blog TechCrunch, wdyl.com was quietly rolled out several days ago and the formal launch was set for Monday, but engineering issues have been holding it back until early Tuesday morning.The site can return users a single page of relevant results across a variety of Google's search services for whatever query is typed into the search box, whose search button is even a heart.For example, after typing in "pasta," several columns appear on the search results page, allowing users to see images of pasta, watch videos of pasta, or browse latest news about pasta.Other search results include pasta-related maps, books, blogs, patents, translation, popularity on the web and etc.