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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) — Call them the ghosts of summer vacations past: two mostly empty cruise ships remain anchored off the coast of San Diego, waiting for the green light to resume operations as the nation grapples with the COVID-19 pandemic.Celebrity’s Millennium and Eclipse cruise ships have been anchored in San Diego since March, when the CDC suspended cruise ship sailings around the country March 14. That order has been extended to at least July 24.Several cruise ship companies have announced voluntary delays until September.After thousands of passengers disembarked from the Eclipse in late March, test results came back showing several passengers were COVID-19 positive.More than a month later, in May, 63 passengers remained quarantined on the Eclipse with hundreds of crew members.A third ship, the Disney Wonder, was anchored in San Diego for the first few months of the pandemic, but departed May 30, said Brianne Page, a public information officer for the Port of San Diego.For now, the Millennium and Eclipse are ghosts of their former selves. All the passengers have now disembarked, along with the vast majority of the crew.Both ships are down to minimal staffing levels of about 80 crew members to maintain the vessels and keep them operational, said Royal Caribbean Cruises spokesman Jonathon Fishman.“As of now, they expect to stay in this position through the summer until our return to service plans are finalized,” Fishman said via email.The ships occasionally pull into port to refuel, but otherwise stay anchored off the coast to avoid port fees that can exceed ,000 a day.When cruise ships pull into port with passengers, companies pay significantly higher fees, ranging from ,000 to ,000 per call, Page said.There were 28 canceled calls due to the pandemic, resulting in roughly million in lost revenue for the Port of San Diego, Page said, plus a staggering ripple effect for the region’s economy.The Port of San Diego estimates that each time a cruise ship visits San Diego as a midpoint in its journey, known in the industry as a “visitation,” the call generates 0,000 in regional economic impact as travelers visit local shops, restaurants and other businesses.Each time a cruise ship starts and ends its journey in San Diego, known as a “homeport,” the regional economic loss is about million, Page said.Using those estimates, the 28 canceled calls resulted in as much as million in regional economic impact.Cruise ships are working with the CDC and other medical professionals to establish safety standards once sailing is allowed to resume, and industry insiders expect the new guidelines may mirror ones recently adopted in Europe.“The European Union has issued guidelines for cruises operating in Europe, which include things like onboard separation by age group, reduced capacity, and COVID testing of all passengers,” said Doug Shupe, a spokesman for the Auto Club of Southern California.Shupe said interest in cruising remains high among Triple-A members, but members are mostly booking cruises for 2021.“We’ve seen that our bookings for 2021, for cruises, are actually higher than what they were this time last year,” he said.He said many cruise lines offered passengers with canceled bookings credits worth up to 125% of their original value. 3313

SAN DIEGO (KGTV) — Before Vice President Mike Pence made his way to Coronado, he spent the morning at the Hilton Bayfront Hotel.The Vice President and Second lady stayed there during their San Diego Visit. A few protestors inflated the now well-known "Baby Trump" outside of the hotel; It's possible the Vice President got a look at the giant balloon. "We're hoping that the Vice President sees this and sees that there is resistance here in San Diego," says protestor Will Johnson. The giant balloon was an attention grabber for many who saw it on Park Boulevard. "I knew he was coming to town, but I didn't know he was staying here," says Kate Permenter. Permenter is in town for a convention and staying at the Hilton Bayfront Hotel, saying, "So last night people kind of started freaking out."Outside of the hotel, security checked every car making its way into the garage. Hotel guests say there are dozens of police officers and secret service agents inside of the hotel. "At every entrance, there are cops just kind of staring at you."Dozens of officers escorted the motorcade as the Vice President left downtown this morning. Protestors said there would be another demonstration outside of the hotel at 7 p.m. but "Baby Trump" will not be in attendance. 1270

SAN DIEGO (KGTV) – Crowds are already flocking to San Diego beaches for the Fourth of July weekend.On Friday, many people claimed their spots early at Mission Beach and Oceanside.While some were able to keep their distance from one another, many did not have on facial coverings when near other people.“The majority of them are not wearing masks, I would say at this point in time,” said Rich Stropky, Marine Safety Lieutenant for San Diego lifeguards.He said more people are expected to make their way to San Diego Saturday as other Southern California beaches will be closed.Law enforcement agencies across San Diego have said they will focus on education, rather than enforcement when someone violates the public health order.He said the parking lots at Mission Beach were full by noon Friday.“As far as the capacity for our beaches, what has limited capacity in the past is the ability to park,” he said. “How far are people willing to park and still walk to the beach? Are they going to Uber in? Are they going to do drop-offs?”Stropky urged beachgoers to talk to lifeguards if they have any questions and to follow the public health order and original beach rules.“We have our COVID safety guidelines, and we want everyone to adhere to that,” he said. “We have our beach regulations; there’s no glass, there’s no dogs between 9 and 6, there’s no camping.”There’s also a beach hazard statement in effect this weekend. Lifeguards expect high surf and dangerous rip currents.“Come talk to us; we want to give you the ins and outs of the beach and keep everybody safe and just have a wonderfully happy Fourth of July.”Governor Gavin Newsom ordered state beaches in Southern California and the Bay Area to close temporarily.To increase safety, the City of Oceanside decided to also close beach parking lots in Oceanside.The goal is to minimize crowding, promote social distancing, and slow the spread of COVID-19. 1922

SAN DIEGO (KGTV) -- California will close state beach parking lots in San Diego County ahead of July Fourth.In a news release Friday, the state listed San Diego among six other counties where parking will also be closed at state beaches.Other state park units will remain open, according to the state, but State Park staff will monitor visitation to ensure compliance with public health orders."Everyone has the responsibility to mitigate the spread of COVID-19, including in the outdoors," the state said. RELATED: Oceanside to close beach parking lots to limit holiday weekend crowdsIn addition, the state says current camping reservations at all state parks will be honored over Fourth of July weekend.The news comes after the City of Oceanside decided Thursday to close beach parking lots over the weekend in an effort to limit holiday gatherings. 859

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