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WASHINGTON, Sept. 14 (Xinhua) -- Controlling diabetes may someday involve mining stem cells from the lining of the uterus, Yale School of Medicine researchers report in a new study published Wednesday in the journal Molecular Therapy. The team treated diabetes in mice by converting cells from the uterine lining into insulin-producing cells.The endometrium or uterine lining, is a source of adult stem cells. These cells generate uterine tissue each month as part of the menstrual cycle. Like other stem cells, however, they can divide to form other kinds of cells.Led by Yale Professor Hugh Taylor, the researchers bathed endometrial stem cells in cultures containing special nutrients and growth factors. Responding to these substances, the endometrial stem cells adopted the characteristics of beta cells in the pancreas that produce insulin. Over the course of a three- week incubation process, the endometrial stem cells took on the shape of beta cells and began to make proteins typically made by beta cells. Some of these cells also produced insulin.After a meal, the body breaks food down into components like the sugar glucose, which then circulates in the blood. In response, beta cells release insulin, which allows the body's cells to take in the circulating glucose. In this study, Taylor and his team exposed the mature stem cells to glucose and found that, like typical beta cells, the cultured cells responded by producing insulin. The team then injected diabetic mice with the mature, insulin-making stem cells. The mice had few working beta cells and very high levels of blood glucose.Mice that did not receive the stem cell therapy continued having high blood sugar levels, developed cataracts and were lethargic. In contrast, mice that received the cell therapy were active and did not develop cataracts, but the animals' blood sugar levels remained higher than normal.The Yale team's findings suggest that endometrial stem cells could be used to develop insulin-producing islet cells, which are found in the pancreas. These islet cells could then be used to advance the study of islet cell transplantation to treat people with diabetes.Taylor said in a statement that the next step in the research will be to verify how long this treatment remains effective.
SYDNEY, July 1 (Xinhua) -- Breastfeeding mothers should limit their use of codeine-containing painkillers to four days as they can cause harm, an Australian doctor warned on Friday.The warning is being discussed at a meeting of anesthetists in Sydney."New mothers should limit their use of codeine-containing painkillers to no more than four days and, if they feel drowsy while taking this medication, cease its use and have their baby examined by a doctor for signs of drowsiness," Sydney's Royal North Shore Hospital anesthetist Dr. Gavin Pattullo said."This is because codeine needs to be metabolized by the liver into morphine to offer pain relief and this liver conversion process is very unpredictable," Pattullo said."Some patients' livers produce large amounts of morphine after taking codeine, causing drowsiness, while others fail to produce any morphine at all."Pattullo said for breastfeeding mothers, a large dose of morphine could make its way into the baby and result in the baby's death by overdose."While new mums shouldn't be unnecessarily alarmed, they need to be aware that codeine-containing painkillers in certain circumstances can cause harm," he said.Breastfeeding mothers are being advised to see a doctor if their baby gets sleepy while taking the painkillers.
BEIJING, Sep. 16 (Xinhuanet) -- Government incentives are important to pave a low-carbon road to economic growth, but companies that improve their industry models and technologies are the main players and also benefit receivers, noted officials and industry insiders at the Summer Davos forum held in Dalian on Sep 14."The most important thing is to have the right direction," said Gao Jifan, chairman and CEO of Trina Solar, a national leading solar panel manufacturer in China.According to Gao, new energy solutions such as solar power, is the "right direction" of future growth, although many deficiencies still exist today. "As long as we have the direction correct, we can succeed as last. But this also requires policies, technologies and investment," he said.Malini Mehra, founder and CEO of the Centre for Social Markets, a non-profit organization that promotes sustainability, said there are two ways in which the governments can support low-carbon businesses to continue along a "green" path."The first is to provide some means of recognizing their good work," she said. And the second is building a measuring system to "verify which company is actually doing well, not just talking about doing well".Preferential policies are only the foundation, said Gao. "We must have a good overall plan along with advanced technologies to bring value back to the investors."Gao envisions that most of the world’s families will have "zero-consumption" houses with energy supply and storage systems relying purely on solar power by 2020.Without grid limitations, the technology can be used everywhere in the world, especially in the less developed areas."The cost of solar technologies has been on the decline over the past few years because of policy incentives and innovations of companies around the world," said Gao.A solar panel producing one watt’s electricity cost in 2005, but now it is reduced to only .2 to .3, he explained."This is the result of technological innovations and large-scale manufacturing. And it makes us more confident to see the solar energy to become a major part of the energy system in the future."Being low-carbon also helps a company attract clients because it is the current fashion and customers are more likely to choose low-carbon products, noted Klaus Kleifeld, CEO of the US aluminum products maker Alcoa Inc."The generation that we recruit today has a very different social consciousness and standards," he said. "They want to see and only want to work for companies that are sustainable."
BEIJING, August 1 (Xinhuanet) -- U.S. researchers have discovered a genetic mutation unique to African Americans that links to heighten their asthma risk, according to reports published on Sunday in the journal Nature Genetics.Researchers of University of Chicago found a gene, PYHIN1, and its variations may account for asthma risk in people of African descent. In their study, they examined data from nine previous genome-wide association studies, totaling more than 2 million single nucleotide polymorphisms in 3,246 asthma patients and 3,385 control patient, 1,702 patient-parent groupings, 355 family-based cases, and 468 family-based controls.In the study, the researchers found that between 26 percent and 29 percent of people of African-descent carried at least one copy of the gene. In particular, one polymorphism of the gene was 34 percent more likely found in African-American and Afro-Caribbean people with asthma. More interestingly, this variant of the gene is rarely found in Caucasian people and in Latino population, it was found in less than 5 percent.This new variant is part of a family of genes linked with the body's response to viral infections. It is thought to be involved in interferon signaling, which could influence the occurrence of asthma.The team stressed that each gene variant on its own plays only a small role in increasing asthma risk, but that risk could be multiplied when combined with other risk genes and with environmental factors.