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At least 10 big businesses have said they will be shuttering some, if not all, of their brick-and-mortar stores this year. Many are affected by the popularity of online shopping.Here are the stores that announced closures in recent months:1. Victoria's SecretSales in 2018 dropped dramatically for Victoria's Secret, and it announced 53 stores will close in 2019.2. JCPenneyAt least 24 JCPenney stores will close in 2019, after it closed dozens in 2018 and 2017.3. Family DollarFamily Dollar announced in March 2019 that it will close 390 stores in the year and make big changes to the stores it is keeping open as the discount chain seeks a turnaround.4. GymboreeGymboree announced in January it has filed for Chapter 11 bankruptcy protection, and that filing has led to the impending closure of 800 stores.5. Payless ShoeSourcePayless ShoeSource filed for bankruptcy a few years ago, and in 2019 announced it will close all of it's stores. Sales on its website immediately closes.6. Charlotte RusseClothing retailer Charlotte Russe will close all of its 416 stores in 2019, which it announced after filing for bankruptcy in February.7. GAPThe CEO of Gap said stores that are not meeting its profitability requirements will close, and the Old Navy brand will be split off and made its own company. Closures will include 230 Gap stores in 2019 and 2020.8. Ann Taylor, Loft, Lane Brant: The Ascena Retail GroupAscena Retail Group owns brands such as Ann Taylor, Loft and Lane Bryant and has been closing stories since 2017. More are expected in 2019.9. Macy'sEight Macy's stores in locations the company believes may be over-saturated will close in 2019. The company closed dozens of stores in 2017.10. LifeWay Christian StoresLifeWay leaders said all of its 170 brick-and-mortar stores will close, but it will continue in the online retail business. 1861

Apple product launches always get buzz, but one new gadget announcement has left some people bemused: a monitor stand that costs nearly as much as some computers.At its annual 188

BALTIMORE — People all over Maryland reported seeing a massive meteor falling from the sky Tuesday night. Many said they saw it in places like Howard County, Anne Arundel County and Washington, D.C.Here is a better view of the 239

ATLANTA, Ga. – Federal officials are investigating a multi-state outbreak of Salmonella Dublin infections linked to ground beef. The Centers for Disease Control (CDC) announced Friday that 10 people infected with the outbreak strain have been 255

Axel Dennis and his family have faced challenging times in his short life after being diagnosed with a rare disease at 5 weeks old. Alex was diagnosed with Spinal Muscular Atrophy Type 1 which is a serious and deadly condition. According to U.S Department of Health and Human Services, symptoms include muscle weakness, lack of motor development and poor muscle tone. Children diagnosed with SMA1 generally are unable to sit up or stand. Left untreated, the disease is typically fatal by age 2. In the past, this diagnosis would have been considered terminal. But a recently developed treatment has made it possible for children to survive and live a normal life. The drug is called Spinraza and it was approved by the FDA in 2016. It allows children to reach and maintain age appropriate developmental milestones, including sitting, crawling, and walking. The drawback is it only slows the progression of the disease. It also has to be injected into the spine every fourth months under anesthesia. Health and Human Services also said that some babies do not respond to the treatment. A second drug was released this year called Zolgensma, which would give Axel likely the best chance of living a normal life. The drug uses gene therapy IV fusion that replaces a missing gene. But the revolutionary drug has a cost of .1 million.According to an article by 1370

来源：资阳报