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LOS ANGELES (CNS) - USC researchers have found the likely order in which COVID-19 symptoms first appear: fever, then cough and muscle pain, followed by nausea, and/or vomiting, and diarrhea, it was announced Thursday.Knowing the order of COVID-19's symptoms may help patients seek care promptly or decide sooner than later to self isolate, according to scientists at the USC Michelson Center for Convergent Bioscience. The information also may help doctors rule out other illnesses, or help doctors plan how to treat patients, and perhaps intervene earlier in the disease.The study, which appears in the journal Frontiers in Public Health, was led by doctoral candidate Joseph Larsen and scientists Peter Kuhn and James Hicks at the USC Michelson Center's Convergent Science Institute in Cancer."This order is especially important to know when we have overlapping cycles of illnesses like the flu that coincide with infections of COVID-19," said Kuhn, a USC professor of medicine, biomedical engineering, and aerospace and mechanical engineering. "Doctors can determine what steps to take to care for the patient, and they may prevent the patient's condition from worsening."Fever and cough are frequently associated with a variety of respiratory illnesses, including influenza, Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome. But the timing and symptoms in the upper and lower gastrointestinal tract set COVID-19 apart."Given that there are now better approaches to treatments for COVID- 19, identifying patients earlier could reduce hospitalization time," Larsen said.To determine COVID symptom chronology, the authors analyzed more than 55,000 confirmed coronavirus cases in China collected from Feb. 16 to Feb. 24 by the World Health Organization. They also studied a dataset of nearly 1,100 cases collected from Dec. 11 through Jan. 29 by the China Medical Treatment Expert Group via the National Health Commission of China.In addition, to compare the order of COVID-19 symptoms to influenza, the researchers examined data from 2,470 cases in North America, Europe and the Southern Hemisphere, which were reported to health authorities from 1994 to 1998."The order of the symptoms matter, " Larsen said. "Knowing that each illness progresses differently means that doctors can identify sooner whether someone likely has COVID-19, or another illness, which can help them make better treatment decisions." 2440

LONDON — People across England face tough new fines if they fail to self isolate after testing positive for COVID-19.Starting Monday, those who fail to follow the rules face a 1,000-pound (,200) fine, which increases to 10,000 pounds for repeat offenders. The Department of Health and Social Care says those who test positive also will be fined if they knowingly provide false information to contact tracers.Health Secretary Matt Hancock says the government will “not hesitate” to introduce further measures to restrict the spread of the coronavirus.The House of Commons on Wednesday may consider an amendment to existing legislation that would give Parliament the right to vote on any new restrictions.Britain already has Europe’s worst death toll from the pandemic, with about 42,000 confirmed deaths. But those who are calling for tighter restrictions are being challenged by critics who fear further damage to the economy.In addition to national restrictions, about one-quarter of the U.K.’s 65 million people are living under tighter local restrictions to fight local outbreaks. 1093

LOS ANGELES (AP) — Mayor Eric Garcetti didn't create the city's homeless crisis, but he owns it.The two-term Democrat who not long ago flirted with a presidential run has been besieged by complaints about homeless encampments that have gotten so widespread he's facing a potential recall campaign.The low-key mayor who in 2016 helped convince voters to borrow .2 billion to construct housing for the homeless has found himself forced to explain why the problems have only gotten worse.Figures released earlier this month showed a 16% jump in LA's homeless population over the last year, pegging it at 36,300 — the size of a small city.That's no surprise to anyone who lives or works in downtown Los Angeles, where tents crowd sidewalks within sight of City Hall and the stench of urine is unmistakable.The homeless crisis has become "a state of emergency," said Alexandra Datig, who is leading the recall effort.It's not clear if the recall effort will succeed — the threshold to reach the ballot requires over 300,000 voter signatures. It nonetheless represents at least a symbolic statement about public unrest with the growing homeless problem. 1157

LONG BEACH, Calif. (CNS) — An allegedly drunken 29-year-old man who celebrated his birthday by riding a horse on the 91 Freeway is now behind bars.About 1 a.m. Saturday, a 911 caller alerted California Highway Patrol officers to the rider on a white Arabian horse, trotting eastbound along the freeway near Paramount Boulevard.Alcohol screening tests allegedly showed that Luis Alfredo Perez of Placentia had a blood-alcohol content of .21 percent, more than double the legal limit, according to a CHP report.RECORD-BREAKING DUI ARRESTS | CAR CHASE BEGINS ON 91 HWY | HORSE REUNITED WITH OWNER AFTER LILAC FIREThe horse, named ``Guera,'' was unharmed and released to the suspect's mother, who was on the scene quickly, according to KTLA5, which first reported the arrest.CHP posted on Twitter, advising the public, "No, you may not ride your horse on the freeway, and certainly not while intoxicated." 919

LONDON (AP) — Angelina Jolie has not ruled out a move into politics — and has joked that she might be tough enough to take the rough and tumble that comes with it.The American actress and U.N. envoy told BBC radio she "can take a lot on the chin" — a possible reference to her bitter divorce from Brad Pitt.When asked if she is moving in the direction of politics, the 43-year-old Oscar winner said, "I honestly will do whatever I think can really make change."Jolie is a special envoy for the U.N. refugee agency. She used her slot as a "guest editor" on the BBC to highlight refugee issues in the Middle East.She also included Chinese artist Ai Weiwei and Nobel Peace Prize winner Denis Mukwege on the show. 717

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