武清做包皮天津市龙济(泌尿外科医院武清龙济) (今日更新中)

I’m at a loss. No words. I’ve been part of two big families with Grant Imahara over the last 22 years. Grant was a truly brilliant engineer, artist and performer, but also just such a generous, easygoing, and gentle PERSON. Working with Grant was so much fun. I’ll miss my friend.— Adam Savage (@donttrythis) July 14, 2020 330

In another sign of the times for retail, Lowe's is closing 51 North American stores.The home improvement chain said Monday that locations are underperforming and the decision will help the hardware chain focus on its most profitable stores and "improve the overall health of its store portfolio."Lowe's (LOW) is shutting down 20 stores in the U.S. and 31 in Canada. The company said that a "majority" of the shuttered stores are within 10 miles of another Lowe's location.The stores will be closed before Feb. 1, 2019. The company will try to find jobs at nearby stores for its employees affected by the closings."We believe our people are the foundation of our business and essential to our future growth," said CEO Marvin R. Ellison.Lowe's is struggling to keep up with its larger rival Home Depot. Ellison, who joined the company in May, has already made some big strategic decisions, including closing all of its Orchard Supply Hardware stores and slashing inventory at its Lowe's stores.The company cut its sales and profit outlook for the year. Its next earnings report is on November 20. 1102

If you aren’t on this medication, chances are you know someone who is. It’s used to treat everything from pain to mood disorders and can be just what the doctor ordered for many.But now, there is mounting research uncovering misuse of and even a black market for this popular prescription.We’re talking about gabapentin. It’s approved for some types of seizures and nerve pain.Doctors also use it off-label to treat everything from insomnia to migraines to anxiety. Sixty-four million prescriptions of it were sold in the U.S. in 2016, up more than 60 percent from four years earlier.The thing is, experts say there is growing evidence it’s being abused, too. It’s even being sold on the streets under the name “Johnnys.” Dr. Joseph Insler, an addiction psychiatrist, says he’s seeing it all too often.“Sometimes, I've even experienced patients ask me for their “Johnnys” and then they'll, maybe, catch themselves and say, ‘No, no, no. I mean gabapentin',” he says.Why is this prescription being misused?“I think that some individuals may say that they use it to get high, and others may say they use it and get a drowsy effect. So, we're talking about the euphoria versus sedation, “ says Rachel Vickers Smith, Ph.D.Dr Vickers Smith wrote her dissertation on gabapentin abuse when studying drug abusers in Appalachia.“We found a nearly 3000 percent increase from 2008 to about 2014 in individuals reporting gabapentin abuse for the purposes of getting high,” she says.We wanted to see for ourselves, so we searched online. We easily found people talking about taking “Johnnys”, or gabapentin, to get high. There were also threads of people trying to spread awareness about the abuse.Experts say gabapentin is typically misused by substance abusers who mix it with other drugs.But, Dr. Insler says it’s also possible for people with legitimate prescriptions to misuse, too.He says, “If somebody’s taking excessively high doses or needing early refills” or if their mood changes, family members or clinicians should see these signs as red flags.A growing body of research shows the problem of abuse, especially among substance abusers is clear.  But some experts also worry about the number of prescriptions being handed out.A recent New England Journal of Medicine letter warned that “clinicians who are desperate for alternatives to opioids” are “increasingly prescribing gabapentin” and that “evidence suggests that some patients misuse, abuse or divert gabapentin.”Dr Rachel Vickers Smith says, “ I think that's why it's really important to get out the message,” about abuse, in general.Gabapentin is not a controlled substance or scheduled drug on the Federal level.We reached out to several government agencies. There was little information on potential abuse although the National Institute on Drug Abuse pointed us to existing research and the DEA says it is beginning to receive calls.Dr Vickers Smith says, “ I don't think that gabapentin abuse is on the CDC, DEA’s, NIDA’s radar, in part because we had this opioid epidemic.”All experts we talked to stress that this is NOT the next opioid epidemic, but they believe gabapentin abuse is something to watch closely and believe more research is needed.We contacted two of the manufacturers of gabapentin, including Pfizer, which told us, “Gabapentin is an important treatment option for their approved indications”. 3416

I can’t even describe what this meant to me and my sisters, my brother, my mom and closest friends to experience together. Thank you so much Kanye for this memory that will last a lifetime ? Here’s a more close up view to see the incredible detail. pic.twitter.com/XpxmuHRNok— Kim Kardashian West (@KimKardashian) October 29, 2020 338

House Republican leaders on Thursday released details of reforms that would overhaul the U.S. tax code, cut individual income tax rates and remove a number of breaks and deductions in the name of making Americans’ tax bills simpler and smaller.Much political wrangling remains before the plan would become law; both houses of Congress must approve the bill, and President Donald Trump has to sign it. But were it to take effect in 2018, as Republicans would like, here’s how the tax plan could change things for you. 529

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