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Scientists are working to eliminate a type of heart disease in dogs using gene therapy. They're zoning in on a heart condition called mitral valve disease that’s common in 6% of dogs. Scientists are using Cavalier King Charles spaniels for the research. They tend to develop it at a younger age. Scientists at Tufts University have already tested gene therapy in mice. A virus is injected into them to deliver DNA to cells which causes them to create a protein. What it essentially does is stops the heart valve from getting thicker, stopping the valve from leaking. Researchers are now moving on to testing this in dogs. But they think the treatment could go beyond just canines. “Many of the dog diseases are naturally occurring and really great models for human disease,” says Dr. Vicky Yang, a veterinary cardiologist and research assistant professor at Cummings School of Veterinary Medicine at Tufts University. “And I can see this, if it becomes successful in dogs, potentially going into thinking about treatment for humans for mitral valve disease.”The biotech company behind the treatment agrees. It says it could also expand beyond heart problems. “I think a larger question, though, is if we are able to prove this thesis of treating aging, making the animal generally healthier, could also treat heart failure, what other diseases could we treat in dogs?” says Daniel Oliver, the CEO of Rejuvenate Bio. “And could we progress this treatment onto past dogs and other animals and possibly humans?” The gene therapy would only be used for dogs just starting to experience heart problems.Researchers still need to make sure the gene therapy is safe for all breeds before they make it available to the public. 1730
"By the grace of God, He kept me from losing my mind," said Viola Burton as she sat in the lobby of the G. Robert Cotton Correctional Facility in Jackson Monday waiting for her son. After 32 agonizing years, Viola's son, Danny, was being released from prison. "I knew in my heart that he couldn't kill nobody," she said.Anxiously waiting with Viola were attorneys Solomon Radner and Madeline Sinkovich from Excolo Law and Claudia Whitman of the National Capital Crime Assistance Network. Fifteen years ago, Danny Burton wrote a letter to Claudia, telling her about his case and that he was innocent. Claudia, who volunteers all of her time to investigate wrongful conviction cases, asked the attorneys to take a look at the case. The law team also investigated, talked to witnesses, and found a prisoner who would eventually sign an affidavit that named the real killers of the 1987 murder of Leonard Ruffin in Detroit."There was a lot of witness intimidation," said attorney Madeline Sinkovich, who added that young witnesses were mistreated by police to get statements. When a tearful Danny Burton walked out of prison, he gave his mother a long embrace. "I'm really shocked," Danny said while appearing to be in a state of disbelief. He wanted to see the rest of his family, but not everyone is still around. Danny's father died years ago from a heart attack. Viola said he just couldn't take the fact that his son was innocent but locked away. Danny's sister passed away last year. Before taking Danny to get some food - he requested McDonald's - his attorney took him to The Suit Depot in Oak Park where owner Marty Babayov, who heard about Danny's case, wanted to give him some new clothes, including suits for court. Danny now wants to help free other men he says are in prison for crimes they didn't commit. "A lot of them can't read or write to seek assistance," Danny said. Friday afternoon, a spokesperson for the Wayne County Prosecutor's Office released the following statement: 2003

A change is coming to some people’s life and health insurance policies that will make them more expensive. Prudential recently announced it will consider e-cigarette users the same as traditional smokers. Smokers pay on average about 50% more per year for life insurance. Depending on the policy, that’s between 0 and 0 more.Some other companies were already charging vapers more. The president of Consumer Watchdog, Jamie Court, says he doesn’t necessarily disagree with the practice. “Well you know I’m no fan of the insurance industry but I think they're probably right in this circumstance and you know vaping is a relatively unknown quantity we don’t have any longitudinal studies to show what happens in 10-20-30-40 years to the lungs of people who vape,” said Court. “But there has been some evidence that people have significant scarring.”Court says it’s a little more of a gray area when it comes to health insurance. Right now, plans under the Affordable Care Act don’t charge e-cigarette and tobacco users the same. Some states don’t allow smokers to be charged more. At the same time, the Insurance Information Institute reports some companies have vaping in the non-smoking category because there isn’t enough data yet on the health effects. But with recent injuries and deaths from vaping, some companies now consider it a higher risk factor. 1375
“These THUGS are dishonoring the memory of George Floyd, and I won’t let that happen. Just spoke to Governor Tim Walz and told him that the Military is with him all the way. Any difficulty and we will assume control but, when the looting starts, the shooting starts. Thank you!” https://t.co/GDwAydcAOw— The White House (@WhiteHouse) May 29, 2020 359
A 7-year-old boy complaining of jaw pain was found to have 526 teeth inside his mouth, according to the hospital in India where he was treated.The boy was admitted last month in the southern city of Chennai because of swelling and pain near his molars in his lower right jaw.When doctors scanned and x-rayed his mouth, they found a sac embedded in his lower jaw filled with "abnormal teeth," Dr. Prathiba Ramani, the head of Oral and Maxillofacial Pathology at Saveetha Dental College and Hospital, told CNN.While the surgery to remove the teeth took place last month, doctors needed time to individually examine each tooth before they could confirm their findings.After discovering the sac, two surgeons removed it from the boy's mouth. Then Ramani's team took four to five hours to empty the sac to confirm its contents and discovered the hundreds of teeth."There were a total of 526 teeth ranging from 0.1 millimeters (.004 inches) to 15 millimeters (0.6 inches). Even the smallest piece had a crown, root and enamel coat indicating it was a tooth," she said.The boy was released three days after the surgery and is expected to make a full recovery, Ramani said.Ramani said the boy was suffering from a very rare condition called compound composite odontoma. She said what caused the condition is unclear, but it could be genetic or it could be due to environmental factors like radiation.The boy actually may have had the extra teeth for some time. His parents told doctors that they had noticed swelling in his jaw when he was as young as 3, but they couldn't do much about it because he would not stay still or allow doctors to examine him.Dr. P. Senthilnathan, head of the hospital's Oral and Maxillofacial Surgery Department and one of two surgeons who operated on the boy, detailed the procedure to CNN."Under general anesthesia, we drilled into the jaw from the top," he said. "We did not break the bone from the sides, meaning reconstruction surgery was not required. The sac was removed. You can think of it as a kind of balloon with small pieces inside."Dr. Senthilnathan said the discovery showed it was important to seek treatment for dental issues as early as possible.Awareness about dental and oral health was improving, he said, though access in rural areas remained problematic."Earlier, things like not as many dentists, lack of education, poverty meant that there was not as much awareness. These problems are still there."You can see people in cities have better awareness but people who are in rural areas are not as educated or able to afford good dental health."In Ravindrath's case, all has turned out well; the boy now has a healthy count of 21 teeth, Dr. Senthilnathan said. 2715
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