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SAN DIEGO (KGTV) - Beer lovers can enjoy the best of San Diego Beer week with a brewery tour.The Beer Train Trolley Tour stops at four local breweries with flights of craft beer; about 15 different beers will be served, along with a light lunch.10News viewers can get a off discount with the coupon code FHNNY4GJ.Check tours and reservations on the San Diego Beer, Wine and Spirits Tours website. 407

SAN DIEGO (KGTV) -- Caltrans maintenance crews closed the westbound Interstate 8 connector to northbound state Route 67 at 9 p.m. Thursday night, but lanes were reopened at 5 a.m. Friday morning. The closure took effect for guardrail repair, according to Caltrans.Signs were posted to direct motorists on westbound I-8 to exit at West Main Street and turn left to eastbound I-8 to SR-67.Motorists were reminded to be work zone alert and slow down when approaching Caltrans vehicles with amber flashing lights.Caltrans says Californians can expect more roadway improvement projects like this made possible by the recently passed Road Repair and Accountability Act of 2017, Senate Bill 1.  715

SAN DIEGO (KGTV) — At least six companies are working on COVID-19 vaccine candidates in San Diego, all within a 1.5-mile radius of where the I-5 and I-805 split.Locally, the farthest along appears to be Inovio Pharmaceuticals, which plans to launch a Phase 2 trial next month, potentially with a simultaneous Phase 3 trial. A Phase 3 trial is the final step in vaccine testing, with thousands of participants.The company is developing the vaccine using a DNA technique that isn’t used in any other vaccines on the market, although some are in the final stages of testing, said Dr. Kate Broderick, who leads Inovio’s vaccine program.To ensure the DNA enters a person’s cells, the company uses a proprietary device about the size of a toothbrush to deliver doses into the skin rather than a needle and syringe. The company announced Tuesday it secured a million grant from the Department of Defense to speed up production of the devices.Just down the street, TriLink Biotechnologies is working with researchers in London on a vaccine candidate that replicates itself in the body. It just started a Phase 1 trial this month.Nearby, Sorrento Therapeutics is working on both a COVID-19 vaccine and a treatment, but it hasn’t advanced yet to human trials. 10News previously featured the company’s efforts, which are based on techniques developed to fight cancer.On the other side of the 805, Arcturus Therapeutics is working with Duke University on a vaccine based on RNA, which acts as a messenger for DNA. There are no vaccines approved for humans that use this RNA approach. Trials are expected to begin in August, according to a tracker by the Milken Institute.UC San Diego is developing a vaccine using plant virus nanotechnology, leveraging an approach that’s used in vaccines against Hepatitis B and shingles. The university is also taking part in research on a COVID treatment.A spokeswoman for San Francisco-based Vir Biotechnology says the company is using its San Diego satellite office to help crunch data for the work on its vaccine, which is a collaboration with GlaxoSmithKline (GSK).GSK, Janssen, and Pfizer each have vaccine candidates of their own and offices near the 5-805 split, but 10News was not able to immediately confirm if any of those companies were conducting COVID research locally. 2318

SAN DIEGO (KGTV) -- Caltrans plans to close a portion of eastbound State Route 56 overnight Thursday.According to the agency, all eastbound lanes of SR-56 at Camino Del Sur as well as the Camino Del Sur on-ramp will close Thursday from 12:01 a.m. to 4 a.m.The closure will take place so crews can work on the Carmel Road overcrossing. The work is part of a county-wide project to install self-reflecting signs.CHECK TRAFFIC CONDITIONSAccording to Caltrans, the new signs will enhance nighttime visibility and will replace signs that require light fixtures. 569

SAN DIEGO (KGTV) — As fans of San Diego's craft beer settle into the family life, their love for the industry certainly continues. So naturally, breweries have looked to help those beer-loving parents with setups that are family- and kid-friendly.And many of San Diego's breweries won't prompt the grandparents to judge why there's a baby in a bar, combining outdoor games and play areas with general family-friendly restaurant atmospheres.RELATED: Pet-friendly restaurants, bars in San Diego     Here are some local stops where you and your kids can enjoy a day out:(It goes without saying, drink responsibly. Some breweries offer designated driver discounts. Please check with the brewery to see if they offer any deals. Ride-sharing services are easy to hail at many local breweries as well!)Stone Brewing - Liberty Station2816 Historic Decatur Rd, San DiegoLiberty Station's Stone Brewing spot is great for families who want a day out, but maybe not the entire day at a brewery. Stone's outdoor area is packed with seating and a pond, all right next to Liberty Station's shops, park, art, and food hall. Ballast Point - Miramar9045 Carroll Way, San DiegoBallast Point's flagship location packs a family-friendly restaurant into a brewery, giving options for the entire family on its menu. It also has an area just outside for games and a firepit. Pizza PortMultiple locationsPizza Port locations have all been a favorite among local parents. They combine the appeal of a family-friendly pizza joint, with the craft beer love of a brewery. Kids can chow down on pizza and play arcade games not far from the beach. Second Chance Beer Co.15378 Avenue of Science #222, San DiegoSecond Chance has a set up like your traditional San Diego brewery (inside a business park) but don't let that fool you. The brewery itself has a big area filled with games like corn hole, Jenga, and darts, as comfy couches for board games. Belching Beaver Brewery302 E Broadway, VistaBelching Beaver's setup in Vista is perfect for families (and dogs). Its restaurant and bar lead out to a massive outdoor area complete with picnic seating, fire pits, and games. AleSmith Brewery9990 AleSmith Ct, San DiegoAleSmith's expansion dining area helps out parents with its own children's play area with chalkboards, books, and crayons. The brewery also has its own Tony Gwynn museum, featuring Gwynn's gear, awards, and history. Station Tavern2204 Fern St, San DiegoStation Tavern isn't a brewery in the traditional sense, but offers up many of the craft brews around San Diego that have put our town on the map. Better yet for parents, it has its own kids area complete with toys, chalkboards, and picnic tables. 2788

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