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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) - As the government shutdown approaches its third week, San Diego’s food stamp recipients are preparing for possible changes to their benefits. The Supplemental Nutrition Assistance Program, or food stamps, helps feed roughly 40 million Americans. According to the USDA, eligible recipients are guaranteed benefits through January. The U.S. Department of Agriculture is expected to make a statement this week on SNAP funding into February, according to San Diego Hunger Coalition spokesman Joseph Shumate, citing the Center on Budget and Policy Priorities (CBPP).Any SNAP adjustments could also increase the burden on San Diego charities. Many Feeding San Diego beneficiaries also rely on SNAP to help their families, the organization said."For every one meal we do, the SNAP program does 12 meals," said Feeding San Diego CEO, Vince Hall. "That is a 12 to 1 ratio, so any cut to SNAP is going to have dramatic effects on charities already struggling to keep up with the demand, the unmet need for food across our communities."Hall says they are preparing for worst-case scenarios, like the shutdown continuing for weeks or months. According to CBPP, the USDA may rule that the only appropriation available for SNAP after January is the program’s billion “contingency reserve,” which was made available through the fiscal year 2018 appropriations act. But SNAP benefits currently amount to about .8 billion a month, so the billion reserve cannot fully fund February benefits.Other feeding programs, including WIC, which provides food aid and nutrition counseling for pregnant women, new mothers and children, and food distribution programs on Indian reservations, will continue on a local level, but additional federal funding won't be provided. School lunch programs will continue through February. The shutdown started Dec. 21. About 420,000 federal employees are working without pay, while 380,000 are being forced to stay home. Associated Press contributed to this report. 2009

SAN DIEGO (KGTV) -- Baseball is back, and that could mean potentially good news for businesses near Petco Park in downtown San Diego.On Tuesday, Major League Baseball announced a 60-game season will begin on July 23 and 24. Players are expected to return for training camps on July 1.While the MLB announcement did not specify the role of fans, multiple reports suggest the season will begin in empty ballparks with no fans in attendance.To reduce travel, the schedule will include 10 games for each team against its divisional opponents, along with 20 games against the opposite leagues corresponding geographical division.For the San Diego Padres, that will mean 10 games each against the San Francisco Giants, Los Angeles Dodgers, Arizona Diamondbacks, and Colorado Rockies. The Padres will also play teams from the American League West."Major League Baseball is thrilled to announce that the 2020 season is on the horizon," MLB Commissioner Robert Manfred said in a news release. "We have provided the Players Association with a schedule to play 60 games and are excited to provide our great fans with Baseball again.Businesses near Petco Park welcomed the news.Brant Crenshaw, co-owner of the sports bar Social Tap, which is located next to the ballpark, said the pandemic has hurt business. He is hopeful that the return of baseball will lead the way for more sports to return. He said it could help bring some customers back, especially if fans aren't yet allowed back into the ballparks."The only way you're going to be able to watch these games is on TV, and you can come down here and watch every game," Crenshaw said. "It's a one-stop-shop, so if you're a fan of teams out of state, we'll have them playing. So, I think it will help to get some sports back on TV.” 1783

SAN DIEGO (KGTV) - Car owners at a senior community in University City woke up to a messy surprise Tuesday morning. Louise, who asked 10news not to identity her, went to her SUV which was parked on Kantor Street, and her heart sank."I walked to my car and saw that the window had been burst.  It was terrifying," said Louise.Glass was everywhere and inside her vehicle was another mess.  Her glove compartment had been tossed, her insurance and registration scattered.  Nothing was missing, but Louise is nervous."Very afraid of the personal information now they know what address I'm actually at," said Louise.It appears someone took a bat or something like that to bash the window, before unlocking their passenger door.  Louise is not the only victim.  Nearby there were more vehicles hit, some 14 in all.  The windows on those vehicles were also shattered.  Some items were stolen and the repairs will cost hundreds of dollars for each incident."A lot of people on fixed incomes. This is really hurting them, because it is costly to put these windows in these cars," said Louise.If you have any information on the case, call the San Diego Police Department's Northern Division at 858-552-1700. 1245

SAN DIEGO (KGTV) -- As the nation continues to process what happened during the first presidential debate, many are expressing frustration about what didn’t happen.Local and national Latino American leaders are calling out the moderator and the candidates for making no mention of the millions of Latinos in the country.Just moments after the debate ended Tuesday night, organizations like the National Association of Hispanic Journalists shared a series of tweets highlighting that Latinos were not mentioned during the debate.According to the Pew Research Center, more than 32 million Latino voters are eligible to vote in November.Voters like Denisse Roldan Newell wanted to hear more from both candidates about their policies on a range of issues.“It's not just immigration, it's not just the border wall, it's having to do with economics, with smalls business development, with affordable health care, with education,” said Roldan Newell.Roberto Alcantar with the Chicano Federation told ABC 10News it was concerning that the candidates made no mention about COVID-19 and it’s disproportionate affect on the Latino community.In San Diego, Latinos make up 34% of the population but 65% of COVID-19 cases."These are not just Latino issues, these are issues for all of us as American. While, yes, we are Latinos, we are American and our issues are America’s issues," said Alcantar. Locally, Latino leaders like Roldan Newell and Alcantar hope the debate organizers and moderators to make a change before the next debate.The next debate is between the vice presidential candidates on Wednesday, October 7th. 1616

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