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WASHINGTON, Aug. 4 (Xinhua) -- U.S. scientists have found two gene mutations occurring in oligodendrogliomas, the second-most common form of brain cancer, according to a study to be published Friday in journal Science.For years scientists have been looking for the primary cancer genes involved in oligodendrogliomas evolvement. Scientists know the two chromosomes held the probable mutations, but the particular gene information remains unclear.Now scientists at Duke University Medical Center and Johns Hopkins University have discovered the most likely genetic mutations that researchers have been hunting for on chromosomes 1 and 19.The genes they identified, CIC or FUBP1, are tumor suppressor genes. The cancer-related pathways that involve these genes could become targets for future treatments, said Hai Yan, a Duke associate professor of pathology and co-corresponding author of the study.The researchers found CIC on chromosome 19 and FUBP1 on chromosome 1 based on an initial study of seven oligodendrogliomas. They found six mutations and two mutations, respectively, in the seven tumors. Further study of 27 more of these tumors showed that there were 12 and three mutations of CIC and FUBP1, respectively. The two genes were rarely mutated in other types of cancers, indicating that they are oligodendroglioma-specific genes.These genes were difficult to find until the technology improved, said Yan."The team used whole genome sequencing technology so that no genes would be excluded, and we found to our surprise that one gene, on chromosome 19, was mutated in six out of the seven initial tumor specimens we sequenced," Yan said. "A mutation frequency of 85 percent is very high."The finding of two additional new genes involved in oligodendrogliomas increases the chances for an effective combination drug therapy for the tumor, Yan said. He envisions a combination cocktail of drugs similar to the combination-drug treatments taken by HIV patients that would target different pathways involved in cancer, and assist both in reducing the chance of relapsing and increasing odds of success.
Robots perform a dance in a competition in Mudanjiang, northeast China's Heilongjiang Province, July 24, 2011. A nationwide robot competition was kicked off in the city on Sunday, with participants from 50 colleges and universities
WASHINGTON, Aug. 11 (Xinhua) -- The unique fossils of an adult plesiosaur and its unborn baby may provide the first evidence that these ancient animals gave live birth like mammals, according to a new study to be published Friday in the journal Science.The 78-million-year-old, 15.4-foot-long (4.7-meter-long) adult specimen is a Polycotylus latippinus, one of the giant, carnivorous, four-flippered reptiles that lived during the Mesozoic Era.Dr. Robin O'Keefe of Marshall University in West Virginia and Dr. Luis Chiappe, Dinosaur Institute director of the Natural History Museum in Los Angeles County, have determined that it is the fossil of an embryonic marine reptile contained within the fossil of its mother.The embryonic skeleton contained within shows much of the developing body, including ribs, 20 vertebrae, shoulders, hips, and paddle bones.O'Keefe and Chiappe have also determined that plesiosaurs were unique among aquatic reptiles in giving birth to a single, large offspring, and that they may have lived in social groups and engaged in parental care.Although live birth has been documented in several other groups of Mesozoic aquatic reptiles, no previous evidence of it has been found in the important order of plesiosaurs."Scientists have long known that the bodies of plesiosaurs were not well suited to climbing onto land and laying eggs in a nest," O'Keefe said."So the lack of evidence of live birth in plesiosaurs has been puzzling. This fossil documents live birth in plesiosaurs for the first time, and so finally resolves this mystery."
HOUSTON, July 25 (Xinhua) -- A shelter-in-place was ordered after a battery caught fire during a testing at NASA's Johnson Space Center Monday morning.A battery was being tested inside a containment system when it got overheated and caught fire at about 9 a.m. local time, ABC quoted the Houston Fire Department (HFD) sources as reporting.A shelter-in-place was issued for a few buildings because it's believed that one of the bi-products of the combustion could be dangerous, HFD said.The fire was put out before 11:30 a.m.A firefighter was injured when a hydrant cap blew off and struck him, according to ABC.