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The US Food and Drug Administration approved two cancer treatments, Vitrakvi and Xospata, this week after expedited reviews.Vitrakvi, approved Monday, is "a treatment for adult and pediatric patients whose cancers have a specific genetic feature (biomarker)."The FDA said in a statement that it is the second approved cancer treatment that is based on a tumor biomarker instead of the place in the body where the tumor originated.Vitrakvi will be used for the treatment of solid tumors that have an NTRK (neurotrophic receptor tyrosine kinase) gene fusion that do not have a known resistance mutation, that are not metastatic or where surgical removal is likely to lead to severe morbidity, and that have no alternative treatments or have progressed after treatments.NTRK genes are rare but occur in many types of cancer, the FDA said, such as mammary analogue secretory carcinoma and infantile fibrosarcoma.Xospata tablets, approved Wednesday, are for the "treatment of adult patients who have relapsed or refractory acute myeloid leukemia (AML) with a FLT3 mutation," according to the FDA.Alongside the tablets, the agency also approved a diagnostic to detect the mutation."Approximately 25 to 30 percent of patients with AML have a mutation in the FLT3 gene. These mutations are associated with a particularly aggressive form of the disease and a higher risk of relapse," Dr. Richard Pazdur, director of the FDA's Oncology Center of Excellence, said in the statement.AML is a rapidly progressing cancer that affects the numbers of normal blood cells and calls for continuous transfusions, the FDA said.Both treatments were granted Priority Review designation.Priority Review, established in 1992, means the FDA aims to review the drug or treatment within six months, opposed to 10 months for a standard review."A Priority Review designation will direct overall attention and resources to the evaluation of applications for drugs that, if approved, would be significant improvements in the safety or effectiveness of the treatment, diagnosis, or prevention of serious conditions when compared to standard applications," the FDA says.Both treatments also received?orphan drug?designation, a status granted to drugs for rare diseases or conditions. 2261

The Southeastern Conference is considering barring league championship events in Mississippi unless the state changes its Confederate-based flag.“It is past time for change to be made to the flag of the State of Mississippi,” Commissioner Greg Sankey said in a statement Thursday. “Our students deserve an opportunity to learn and compete in environments that are inclusive and welcoming to all. In the event there is no change, there will be consideration of precluding Southeastern Conference championship events from being conducted in the State of Mississippi until the flag is changed.”The NCAA has already said it would not schedule postseason events in Mississippi because of the state flag.National protests about racial injustice have renewed debate about Confederate symbols. Mississippi has the last state flag that includes the battle emblem: a red field topped by a blue X with 13 white stars. White supremacists put the symbol on the flag in 1894 during the backlash to black political power that developed during Reconstruction.During a Black Lives Matter protest June 5 outside the Mississippi Governor’s Mansion in downtown Jackson, thousands of people cheered as an 18-year-old organizer, Maisie Brown, called for the removal of all Confederate symbols in the state, including from the flag.Bipartisan coalitions of state lawmakers have been trying to build momentum to change the flag, but Republican Gov. Tate Reeves has said repeatedly that if the banner is to be redesigned, it should be done by the state’s voters.People who voted in a 2001 election chose to keep the flag rather that replace it with a design that did not include the Confederate emblem.All of Mississippi’s public universities and several cities and counties have stopped flying the state flag in recent years because of the emblem. The state has two SEC schools — the University of Mississippi and Mississippi State University.Leaders at both universities said Thursday that the state should change the flag.“Mississippi needs a flag that represents the qualities about our state that unite us, not those that still divide us,” Ole Miss Chancellor Glenn Boyce and athletic director Keith Carter said in a joint statement. “We support the SEC’s position for changing the Mississippi state flag to an image that is more welcoming and inclusive for all people.”Mississippi State President Mark E. Keenum said in a statement that he respects Sankey’s position. Keenum said he wrote to state elected officials June 12 telling them that the university’s students, faculty and administrators have been on record in favor of changing the flag since 2015.“The letter said, in part, that our flag should be unifying, not a symbol that divides us,” Keenum said. “I emphasized that it is time for a renewed, respectful debate on this issue.” 2829

The U.S. women’s national team wants the U.S. Soccer Federation to repeal the anthem policy it instituted after Megan Rapinoe started kneeling during the “The Star-Spangled Banner.”The U.S. women’s team also wants the federation to state publicly that the policy was wrong and issue an apology to the team’s black players and supporters.“Further, we believe the Federation should lay out its plans on how it will now support the message and movement that it tried to silence four years ago,” the U.S. women’s team said in a statement posted on the Twitter feed of its players association Monday night.Rapinoe took a knee during the anthem at a pair of national team matches in 2016. She said she wanted to express solidarity with San Francisco 49ers quarterback Colin Kaepernick, who silently took a knee during the national anthem before NFL games to raise awareness of police brutality and racial injustice.The U.S. Soccer Federation then approved a policy in February 2017 that stated players “shall stand respectfully” during national anthems. The policy remains in place, though the unions for the men’s and women’s teams believe it doesn’t apply to their players because of their collective bargaining agreements.Kaepernick and Rapinoe each faced sharp criticism for the protest for years. But public sentiment has changed since George Floyd’s death last month.Floyd, a black man, died after a white Minneapolis police officer pressed his knee into Floyd’s neck while Floyd was handcuffed and saying that he couldn’t breathe. His death sparked protests in Minneapolis and around the country, some of which became violent.A lawyer for the men’s team union also called for the repeal of the policy and an apology in a statement provided to BuzzFeed News, which was the first to report on the U.S. women’s statement.A message was left by the AP seeking comment from the federation.___More AP soccer: https://apnews.com/Soccer and https://twitter.com/AP_Sports 1970

The US Postal Service is asking for the biggest price jump on stamps in its history.Facing pressure from the Trump administration to address a revenue shortfall, the Postal Service on Wednesday proposed raising the price of 1-oz. letters from 50 cents to 55 cents, which would be a record nominal increase if approved. The price of each additional ounce would go down slightly.The request was made by the USPS' board of governors, which has been operating on an emergency basis?because of a lack of confirmed members. It will have to be approved by the Postal Regulatory Commission."The Governors believe these new rates will keep the Postal Service competitive while providing the agency with needed revenue," the USPS said in a press release. "The Postal Service has some of the lowest letter mail postage rates in the industrialized world and also continues to offer a great value in shipping."Rates for mailing services -- which includes catalogs and magazines as well as letters -- are pegged to consumer prices. Those have been rising faster this year, but still limited the price hike for that category to 2.5 percent.Prices for packages, however, can float with market rates. The USPS wants to boost Priority Mail prices by an average of 5.9%. A small flat-rate box that costs .20 to ship, for example, would next year cost .90.The steep price increases come at a time when the USPS' losses have been mounting, dragged down in part by a requirement that the quasi-public agency pre-fund the cost of retiree health benefits.As letters and advertising mailers have been replaced by e-mail and online ads, the USPS has been making less and less money. Revenue from first-class mail declined from .4 billion in fiscal year 2015 to .6 billion in 2017.Package revenues fueled by the rise in e-commerce have been a bright spot, bringing in .5 billion in 2017, up from billion in 2015. But it hasn't made much of a dent in the .7 billion net deficit that the Post Office has accumulated over the years.The White House has proposed privatizing the Post Office, a plan that postal unions protested in nationwide demonstrations on Monday.President Donald Trump has repeatedly criticized the terms of USPS' contract to deliver Amazon packages, the details of which are confidential. The Postal Service says it makes a profit through the arrangement."Why is the United States Post Office, which is losing many billions of dollars a year, while charging Amazon and others so little to deliver their packages, making Amazon richer and the Post Office dumber and poorer?" Trump tweeted last December. "Should be charging MUCH MORE!"In April, Trump ordered a review of the Postal Service's business model by a task force led by the Treasury Department. Postal Service spokesman Carl Walton says the review has been completed, but that the agency hasn't seen it yet."I think they're waiting until after the elections," Walton said. "We're waiting just like everybody else." 3041

The Wisconsin Division of Criminal Investigation (DCI) identified Rusten Sheskey as the officer who shot Jacob Blake seven times in the back in Kenosha, Wisconsin on Sunday.The DCI, which provided its first update on the case late Wednesday, nearly 72 hours after the shooting, said its continuing its investigation, but is not pressing charges as of now.The shooting has prompted massive unrest in Kenosha since. The unrest culminated in a shooting incident that killed two people and injured one person on Tuesday amid the late-night demonstration. A 17-year-old was arrested in connection to Tuesday's shooting.In response to Sunday’s shooting, professional athletes in multiple sports boycotted scheduled games. All three NBA Playoff games on Wednesday were postponed, and a MLB game between the Milwaukee Brewers and Cincinnati Reds was also postponed.Investigators said that Sheskey, who was placed on administrative leave, has been with the police department for seven years.The DCI gave the following description of Sunday’s incident:“During the incident, officers attempted to arrest Jacob S. Blake, age 29. Law enforcement deployed a taser to attempt to stop Mr. Blake, however the taser was not successful in stopping Mr. Blake. Mr. Blake walked around his vehicle, opened the driver’s side door, and leaned forward. While holding onto Mr. Blake’s shirt, Officer Rusten Sheskey fired his service weapon seven times. Officer Sheskey fired the weapon into Mr. Blake’s back. No other officer fired their weapon. Kenosha Police Department does not have body cameras, therefore the officers were not wearing body cameras.”Officials also said that Blake told officers he had a knife. The DCI said that officials later found a knife on the driver's side floor of the car.The only videos of the incident were take bystanders that showed Blake opening his car door before he was shot at a close distance by Sheskey.Blake’s family said on Tuesday that the 29-year-old is partially paralyzed, but was fortunate to survive from his injuries. 2048