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Holidays will look different this year for many Americans, with dinners outside, social distancing, or passing on family gatherings altogether. But several companies developing rapid at-home COVID-19 tests are hopeful that won't be the case next year. The goal is to make inexpensive, easy-to-use COVID tests that can deliver results in minutes, just like a pregnancy test. "For people to feel comfortable to associate with friends or family, there needs to be a testing methodology ideally that can be performed at home," said Tony Lemmo, CEO of the manufacturing company BioDot.The company's technology is being used by over 70 manufacturers worldwide making COVID-19 antigen, antibody, and PCR tests. Their automated platforms dispense nanoliter/picoliter amounts of reagent onto the tests accurately and fast.Lemmo says just one of their systems can support the production of roughly 100 million COVID-19 tests per year, helping to make high-volume production possible.“We knew we were going to be called on by customers to manufacture more equipment to provide them the ability to manufacture more tests," said Lemmo. To meet customer demand, BioDot increased staffing and built a new facility, compressing production time from months to weeks. The FDA recently authorized the first rapid at-home test that can deliver results in 30 minutes, eliminating the need for a lab to test the sample. But the molecular single-use test will only be available to patients with a doctor's prescription who are suspected of being infected with COVID-19.Companies developing tests hope the FDA will soon authorize another at-home testing tool: the rapid antigen test.These inexpensive tests provide results within minutes, and companies developing them say millions could be sold without a doctor's referral.“From what we’re hearing, it’s really just a matter of possibly months before there’s at least sufficient data to be able to support an at-home use of a test like an antigen test," said Lemmo.Lemmo says if authorized by the FDA, manufacturers could make millions of these tests in a matter of months. But antigen tests are less accurate, and the FDA wants to ensure they'll be simple enough for people to use at home. There are also concerns over how the data will be reported to health authorities. “I think any at-home testing or massive rollout of a test into the communities needs to be done very carefully and with a lot of education around it," said Clinical Lab Director Melissa Miller. Dr. Miller is a professor of pathology and laboratory medicine at the University of North Carolina Chapel Hill and Medical Director for the Clinical Microbiology Lab for the Medical Center.She worries the inaccuracies of these tests could eventually lead the public to lose trust in all testing. “Even at 98 percent specificity, which is very, very high. That means you’re going to have a false positive two out of every 100. If you started testing a hundred million people, this is millions of people who have a false-positive test," said Dr. Miller. She says this could lead to healthy people isolating and missing work or school unnecessarily, and false-negative results could give people a false sense of security. “These rapid antigen tests were pushed out to skilled nursing facilities; this is a very high-risk patient population. This is actually where you want a very accurate test," said Dr. Miller. She says it’s unclear how well antigen tests detect the virus in asymptomatic patients but agrees more data is needed to figure that out.“It might make more sense for K-12 schools, or even college settings, where there’s less risk for a poor outcome if you have a false positive or a false negative," said Dr. Miller. But with a growing demand for convenient at-home testing, manufacturers are hopeful that in the months ahead, the FDA will soon open the door to new solutions. 3889

GERMANY — Bayer plans to slash thousands of jobs as part of a corporate overhaul following its acquisition of Monsanto.The chemicals and pharmaceuticals group said it would cut 12,000 jobs out of its global workforce of 118,000 by the end of 2021. A significant number of reductions will be made in its home market of Germany.More than 4,000 jobs will go at the company's crop sciences division, a consequence of Bayer's acquisition of US rival Monsanto earlier this year.Bayer (BAYRY) spent over billion buying Monsanto. To gain regulatory approval for the deal, Bayer agreed to sell assets including its seed business and some herbicide brands.The German company said in a statement on Thursday that it was considering whether to sell more assets, including the sunscreen business Coppertone and footwear brand Dr. Scholl's.It will get out of the business of animal health, and sell its 60% stake in Currenta, a company that provides services to chemical companies.Shares in Bayer have dropped by more than a third so far this year, in part because of concerns over the company's exposure to lawsuits involving Roundup, a weedkiller made by Monsanto.In August, San Francisco jurors awarded 9 million in damages to a former school groundskeeper who said his terminal cancer had been caused by the product.The damages were later reduced by a judge, but hundreds of other patients have made similar claims. Monsanto has said the product is safe when used as directed. 1481

From coast to coast we found hundreds of people sharing similar stories.Men, women and children all spoke of scalp sores, bald spots and hair falling out in clumps.Jessica Deets said her hair started falling out at an alarming rate two months after she began shampooing with Monat. She also estimates her daughter lost most of her hair after using Monat's children's line. Jessica showed us the clumps she says she found in little girl’s crib. 451

Gun raffles or giveaways aren't anything new, especially in rural parts of the country. But they're drawing renewed scrutiny after 17 people were killed last week in a mass shooting at a Florida high school.Some people are outraged that a lot of gun raffles are giving away AR-15-style rifles, the type used in multiple mass shootings. Police say Nikolas Cruz used an AR-15-style rifle February 14 at Marjory Stoneman Douglas High School in Parkland, Florida.A raffle currently underway in Kentucky is raising funds for the Central Kentucky Batcats, a girls' softball team. Buy a ticket and you could win a semiautomatic pistol or an AR-15-style rifle kit.While some people have complained about the raffle -- which began before the Florida shooting -- the store has mostly received calls of support, said Kenny Barnett, owner of Fully Loaded Inc., an outdoor and sporting goods store in Lawrenceburg that's providing the guns for the raffle."I've had calls both ways," Barnett told CNN. "For every one against, I've probably had 10 more asking where can they buy tickets?"'Truly astonished' 1103

Here's what's happening in the world of politics Saturday, April 21, 2018.WaPo: Sessions threatened to resign if Rosenstein was fired-- Attorney General Jeff Sessions reportedly threatened to resign if President Trump fired Deputy Attorney General Rod Rosenstein, who oversees the Russia probe.Sessions reportedly told the White House he would have considered leaving if Trump had fired Rosenstein, though another source told the Post, that the comment was less a threat and more an attempt to convey his difficult position.CNN reported this month that the White House was preparing an effort to undermine Rosenstein.Read more. 665