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WELLINGTON, May 24 (Xinhua) -- New Zealand researchers have found a way to stop the growth of certain cancer tumors by " silencing" a group of PAX genes, members of a small family of genes that play important roles in embryonic development, but also allow cancer cells to grow and divide in adult tissue.In an article published in UK medical journal Oncogene, Otago University Professor Michael Eccles and colleagues revealed how they used the PAX8 gene to kill cancer cells.After detecting high levels of PAX8 protein in the majority of kidney, ovarian and thyroid cancers they studied, the researchers used molecular techniques to silence the PAX8 gene in several cancer cell lines."We found that these PAX8-depleted cancer cells ceased growing and dividing. The cells were essentially stopped in their tracks through the failure of multiple mechanisms and pathways crucial to their cell division cycle. They then entered into a state called senescence in which they no longer divided, and after that they ultimately died," Eccles said in a statement from the university Tuesday.The findings suggested that PAX8 could be a good target for the development of new cancer therapies, he said."Any resulting drugs would be a long way down the road, but in the meantime this research helps confirm that a focus on PAX genes may prove to be a fruitful line of attack against a number of cancers," he said.The research was supported by grants from the Health Research Council of New Zealand. It formed the main piece of work carried out by Otago doctoral graduate Caiyun (Grace) Li, now a postdoctoral fellow at Stanford University. Study co-authors also included Professor Antony Braithwaite and master's student Jen Nyman.In 2003, research led by Eccles discovered that proteins from one or more of the nine PAX genes were present in many common cancers. They found that "silencing" the gene expression of PAX2 in ovarian and bladder cancer cells, and of PAX3 in melanoma, led to the rapid death of the cells.

BEIJING, March 11(Xinhuanet)-- People with more fat around their waist, often known as “apple shape”, may not have a greater risk of heart attack than those with fatter bottoms and hips, according to a new study published in Lancet as quotted by media reports Friday.This study funded by the Medical Research Council and British Heart Foundation, reviewed 220,000 individual records from 17 countries and monitored the occurrence of heart attacks or strokes based on body mass index (BMI) versus waist-hip circumference. It found that people with "apple-shaped" obesity were at a higher risk of having heart risks compared to those with general obesity as assessed by their BMI.  This contradicts previous claims that "apple shaped" bodies were three times more likely to suffer heart attacks than those with more generally distributed fat.But experts warn obesity is still bad for the heart, no matter where the fat is, and they argue there is confusion about the best way to measure it. "Regardless of how you measure it, being obese is bad for your heart. This study suggests that measuring your waist is no better than calculating your BMI but it's not time to throw away the tape measure just yet, “Dr Mike Knapton, associate medical director at the British Heart Foundation said."We tend to underestimate our body shape and size, so measuring our waist or checking our BMI are both quick and easy ways we can check our health at home."Besides, he also listed some other heart risk factors that we need to think about too, such as blood pressure, cholesterol, diabetes and smoking.

BEIJING, March 29 (Xinhuanet) -- A new study has found that rejection can literally hurt in the same way as physical pain does, according to media reports Tuesday.Researchers found that intense emotional pain, such as feelings of rejection after a breakup of a relationship, can trigger brain activities similar to when people suffer physical pain.The research findings were published in Tuesday's Proceedings of the National Academy of Sciences.The study followed 40 volunteers who experienced unwanted romantic breakups in the past six months, and the researchers analyzed their brain activity during two "painful" situations.The results showed that the two situations, thinking about the loss of their ex-partner and experiencing mild physical pain similar to holding a very hot coffee cup, caused response in the overlapping parts of the brain."This tells us how serious rejection can be sometimes," said study author Edward E. Smith, director of cognitive neuroscience at Columbia University. Smith added. "Our ultimate goal is to see what kind of therapeutic approach might be useful in relieving the pain of rejection."

MOSCOW, May 13 (Xinhua) -- The main and backup crews that will fly to the International Space Station in June have passed preflight tests and are ready for space travel, the Russian Cosmonauts Training Center said Friday.The main crew includes Russian cosmonaut Sergei Volkov, Japanese astronaut Satoshi Furukawa and American astronaut Michael Fossuma.A Russian spaceship Soyuz TMA-02M will send the crew to the space station on June 8, Interfax news agency reported.The backup crew includes members from Russia, the Netherlands and the United States.The crews were tested on the various emergency situations they could face during the flight.Next Monday, the commission will make a final choice of crewmembers for the launch.The crew will spend 161 days in orbit and conduct three space walks.

JINAN, May 14 (Xinhua) -- Chinese scientists said Saturday that they have found a new species of giant theropod dinosaur in the eastern province of Shandong.The new species, described as a close relative of Tyrannosaurus rex (T. rex), has been named "Zhuchengtyrannus magnus". Paleontological experts found it has unique upper jawbones after examining the skull and jawbones discovered in the city of Zhucheng.It was estimated to be about 11 meters long and 4 meters tall, weighing close to 7 tonnes."We discovered two kinds of tyrannosaurus fossils here and the identity of the other one still remains unclear," said Xu Xing, a researcher at the Institute of Vertebrate Paleontology and Paleoanthropology under the Chinese Academy of Sciences."We've named the new genus Zhuchengtyrannus magnus, which means the 'Tyrant from Zhucheng' because the bones were found in Zhucheng," Xu said.The bones were a few centimeters smaller than the similar bones in the largest T. Rex specimen, so there was no doubt that Zhuchengtyrannus was a huge tyrannosaur, Xu said.According to Xu, Zhuchengtyrannus magnus belonged to a specialized group of gigantic theropods called tyrannosaurines which existed in North America and eastern Asia during the Late Cretaceous Period that dated back about 65 to 99 million years.All tyrannosaurs were carnivorous, bipedal animals that generally had small arms and large skulls. Among the tyrannosaurs, the tyrannosaurines were the largest and characterized by having just two fingers on each hand and large powerful jaws to deliver a bone crushing bite. They were likely both predators and scavengers.The fossil quarry in Zhucheng contains one of the largest concentrations of dinosaur bones in the world. At least 10 dinosaur species have been found in three rounds of excavations since the 1960s, including Tyrannosaurus and Hadrosaurs.