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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) — Beautiful sunsets may be considered a common occurrence in San Diego but that doesn't make them any less special.While pretty much any spot in San Diego can be considered "the best place to see sunsets," there are some areas that capture the scene better.And yes, many of them are at the beach.RELATED: San Diego's?most picturesque spotsBut that's not to say there aren't great places elsewhere! So if you're ready to grab your camera or just observe with your eyes, here's where to enjoy a breath-taking sunset around the county:Sunset CliffsIt's in the name. Sunset Cliffs gives photographers and anyone peering out to sea nearly 180-degrees of sky meeting water to gaze at. And during a sunset, that can create some amazing viewings as colors are reflected off the waves.Balboa ParkAs San Diego's crown jewel, Balboa Park lends itself to beautiful scenes museums and landscaping with the city in the background. Drop in a sunset and those scenes seem to transform once your eyes hit the horizon.Lake CuyamacaThe Lake Cuyamaca area brings San Diego's routinely dry, East County landscape together with the calmness of the lake. Sunsets are reflected beautifully off the lake, while the dry brush and mountains on the horizon can split through, creating some stunning imagery.Temecula wine countryUp north, San Diego County's wine region creates a mesmerizing foreground to sunsets. Between the vines curling up and over one another, rays of sunlight break through.Oceanside HarborThere nothing quite like a shot of the sun peering over masts and sails from boats bundled together in a harbor. Though there may not be a lot of reflection of the water, there's plenty to stand in awe and observe. 1733

SAN DIEGO (KGTV) - Community leaders are reacting to this week's move by state lawmakers to let voters decide in November whether to reinstate affirmative action.“It’s been a long, hard road and now we can actually see some light at the end of the tunnel,” said San Diego NAACP President Francine Maxwell on Thursday afternoon. It follows Wednesday's news that California lawmakers approved a proposal to repeal the 25-year-old law that bans looking at race, sex, ethnicity, color or national origin in college admissions, contracting and public employment.“The NAACP San Diego branch is elated that it was a 30-10 vote. Two-thirds majority said that things have to change and we're headed to November,” she added.Assemblymember Shirley Weber (D-San Diego) authored the bill and asked for support on ACA 5, which lets voters decide whether to reinstate affirmative action by repealing Prop 209.“The ongoing pandemic as well as recent tragedies of police violence is forcing Californians to acknowledge the deep-seated inequality and far-reaching institutional failures that show that race and gender still matters,” she told her colleagues this week.“African Americans have been at the bottom for over 401 years. Affirmative action was an opportunity so they could open the door to walk into colleges, to [have] the opportunity of economics, to change the narrative of their family,” Maxwell told ABC10 News.Republican Assembly candidate June Cutter from San Diego opposes the return of affirmative action. Thursday, she told ABC10 News, “It is a band-aid put at the end of the problem rather than trying to find a solution to the disparity that I absolutely acknowledge exists and instead of trying to fix it at the starting line we're trying to fix it at the finish line and that's what I have a real problem with.”Cutter said she believes real change needs to happen earlier through the course of opportunities in K -12 education within under-served and under-privileged communities.Assemblymember Weber was unavailable for an interview on Thursday but her office sent ABC10 News the following statement.“The fate of Prop. 209 will now be in the hands of voters on November 3rd. While it was sold as a civil rights law when it passed in 1996, Proposition 209 has cost women- and minority-owned businesses .1 billion each year, perpetuated a wage gap wherein women make 80 cents on every dollar made by men, and allowed discriminatory hiring and contracting practices to continue unhindered. Far from being colorblind, the bill has set up barriers to women and minorities to share in the economic life of California. Proposition 209 has hindered public policy, thwarted opportunity and maintained economic disparity long enough. It’s time to give voters a chance to right this wrong.” 2796

SAN DIEGO (KGTV) - Clothing retailer Forever 21 announced Tuesday it may close three stores in San Diego County as part of its Chapter 11 bankruptcy restructuring. The affected locations, which include Fashion Valley, University Towne Center, and Parkway Plaza in El Cajon, could be shut down "pending the outcome of continued conversations with landlords,” according to court documents. Attorneys also said the list of store closures could change pending restructuring efforts.Forever 21 has 800 stores worldwide and plans to close almost 200. "We do however expect a significant number of these stores will remain open and operate as usual, and we do not expect to exit any major markets in the US," the company said. The chain was founded in 1984 in a small Los Angeles store by South Korean immigrants Do Won Chang and his wife, Jin Sook. The chain expanded quickly in suburban malls, and catering to young girls and women with a mix of inexpensive basics. The company perfected the fast-fashion model, drawing in customers with its frequently updated mix of clothes than what was offered at department stores or single brands.CNN contributed to this story. 1169

SAN DIEGO (KGTV) — Border agents arrested 15 people over Presidents’ Day weekend during a smuggling event in Mission Bay.U.S. Border Patrol agents caught the smuggling incident in action on Saturday at about 2 p.m. at a Ski Beach launch ramp. As agents got closer, they say they noticed a large group of people quickly exiting the boat and heading for three vehicles.Agents stopped the individuals from getting away and questioned all 15 people involved in the incident.Agents say six people in the group were suspected of human smuggling and arrested. Five of them are U.S. citizens, including four men ranging from 20 to 30 years old and one 25-year-old woman, according to border officials.The nine other people arrested were male Mexican nationals ranging from 27 to 41 years old who admitted to being illegally present.U.S. Border Patrol seized the boat and three vehicles at the scene. 899