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A husband and wife were found dead in Wisconsin Monday morning, and now a search is on for their missing 13-year-old daughter. The parents' bodies were found inside a Barron County, Wisc. after someone called 911 for help before 1 a.m.Deputies said they didn't find any weapons inside. Deputies said the teen, identified as 13-year-old Jayme Closs, could be in danger. No suspects have been named yet, and the FBI is involved in the investigation. An Amber Alert was issued in hopes of finding Closs. The 13-year-old may have been spotted in Miami, police tweeted late Monday night.  621

A cold front dropping down from Canada will be giving hundreds of thousands of people weather whiplash this week, with 30-to-50 degree 24-hour drops forecasted between Monday and Tuesday for sections of the Rocky Mountain west and western plains.Excessive heat warnings are in effect from southern Oregon to southern Arizona on Monday, according to the National Weather Service. As an early season cold blast moves south, those will be replaced Tuesday with winter weather and frost warnings along the Rockies and western plains, and wind advisories in neighboring states. 580

A couple arrested in Mexico while pushing a baby stroller filled with human body parts may have killed up to 20 women, according to the chief investigator on the case.The man and woman were detained Thursday in the Mexico City suburb of Ecatepec on suspicion of murdering 10 female victims. However, the male suspect has since claimed that they are responsible for twice as many deaths.Police arrested the pair, identified only as "Juan Carlos N." and his wife "Patricia "N.," during an investigation into the disappearance of three women and a two-month-old baby. The man gave detailed accounts of the original 10 deaths. He also told police that he and his wife had killed a further 10 people, according to State of Mexico Prosecutor Alejandro Gomez and reported by AFP.Police found eight plastic buckets full of dismembered body parts and cement in the couple's house, Gomez revealed in a Facebook post on Sunday. More remains were found in a refrigerator, wrapped in plastic bags. Tests are now being carried out on the grisly evidence. 1048

A final analysis of a COVID-19 vaccine candidate produced by Pfizer and BioNTech shows that the drug is 95% effective in preventing the coronavirus, and the companies say they hope to apply for Emergency Use Authorization within "days," the company reported Wednesday.The announcement is an improvement from an initial analysis released by the company just over a week ago that showed the drug to be 90% effective. Those results were released when it had been confirmed that 94 participants in the trial who received a shot had contracted COVID-19, and only 10% of those participants who contracted the virus had actually received the vaccine. Updated information now shows that 170 people who participated in the trial have contracted COVID-19, which crosses the threshold for final analysis. Of those participants, 162 received a placebo shot. Of the 20,000 participants who received the vaccine, just one has developed a severe case of COVID-19. The other seven people who received the vaccine and caught the virus are only experiencing mild symptoms.Pfizer also added that the vaccine has proven to be 94% efficient in older people — a welcome sign, given that the virus tends to present more severe symptoms in elderly patients.Pfizer's trial included about 40,000 participants, half of which received the vaccine, and the other half which received the placebo. The vaccine requires two shots, which need to be taken 28 days apart.The company added that there have been no safety concerns with the vaccine. In a randomized survey of 8,000 participants, only 2% reported suffering severe fatigue, and only 4% reported suffering severe headaches. Those who say they suffered side effects only experienced them briefly after vaccination.Wednesday's announcement means Pfizer is on track to shatter records for vaccine development, a process that typically takes several years.Pfizer and BioNTech already have their vaccine candidate in production, meaning it will be ready for distribution as soon as the Food and Drug Administration grants Emergency Use Authorization.Pfizer's announcement comes days after an initial analysis of a Moderna-produced vaccine was also shown to be 95% effective. Several other companies also have a COVID-19 vaccine in the works, something that health officials say is important for logistics and safety. 2347

A longtime national security aide to President-elect Joe Biden, Antony Blinken, is the leading contender to become Biden's nominee for secretary of state. Multiple people familiar with the Biden team’s planning tell The Associated Press that Blinken is at the front of his choices to be America's top diplomat. Blinken served as deputy secretary of state and deputy national security adviser during the Obama administration. If chosen and confirmed, he would be a leading force in Biden's bid to reframe the U.S. global relationship after four years in which President Donald Trump questioned longtime alliances.The President-elect is moving quickly to fill out his administration and could name other top Cabinet nominations as early as next week. Biden’s team is considering releasing his Cabinet picks in groups focused on a specific topic area. Such a move is intended to deliver the message that Biden is intent on preparing for the presidency even as President Donald Trump refuses to concede and attempts to subvert the election results. 1052