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LOS ANGELES (CNS) - USC researchers have found the likely order in which COVID-19 symptoms first appear: fever, then cough and muscle pain, followed by nausea, and/or vomiting, and diarrhea, it was announced Thursday.Knowing the order of COVID-19's symptoms may help patients seek care promptly or decide sooner than later to self isolate, according to scientists at the USC Michelson Center for Convergent Bioscience. The information also may help doctors rule out other illnesses, or help doctors plan how to treat patients, and perhaps intervene earlier in the disease.The study, which appears in the journal Frontiers in Public Health, was led by doctoral candidate Joseph Larsen and scientists Peter Kuhn and James Hicks at the USC Michelson Center's Convergent Science Institute in Cancer."This order is especially important to know when we have overlapping cycles of illnesses like the flu that coincide with infections of COVID-19," said Kuhn, a USC professor of medicine, biomedical engineering, and aerospace and mechanical engineering. "Doctors can determine what steps to take to care for the patient, and they may prevent the patient's condition from worsening."Fever and cough are frequently associated with a variety of respiratory illnesses, including influenza, Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome. But the timing and symptoms in the upper and lower gastrointestinal tract set COVID-19 apart."Given that there are now better approaches to treatments for COVID- 19, identifying patients earlier could reduce hospitalization time," Larsen said.To determine COVID symptom chronology, the authors analyzed more than 55,000 confirmed coronavirus cases in China collected from Feb. 16 to Feb. 24 by the World Health Organization. They also studied a dataset of nearly 1,100 cases collected from Dec. 11 through Jan. 29 by the China Medical Treatment Expert Group via the National Health Commission of China.In addition, to compare the order of COVID-19 symptoms to influenza, the researchers examined data from 2,470 cases in North America, Europe and the Southern Hemisphere, which were reported to health authorities from 1994 to 1998."The order of the symptoms matter, " Larsen said. "Knowing that each illness progresses differently means that doctors can identify sooner whether someone likely has COVID-19, or another illness, which can help them make better treatment decisions." 2440
LOS ANGELES (AP) — U.S. Customs and Border Protection says its officers at the Los Angeles-Long Beach ports complex recently seized more than 14,800 pairs of counterfeit Nike shoes in a shipment arriving from China.The agency says Wednesday that had the fake special edition and retro design shoes been real, the manufacturer's suggested retail prices would have totaled more than .2 million.The shoes were in two containers with contents declared as napkins.The agency says the shoes violated protected designs and trademarks for various versions of Nike's Air Jordan and Air Max shoes.Customs and Border Protection says collectors might pay between ,500 and ,000 for a legitimate pair of the shoes. 714

LOS ANGELES (AP) — Authorities are seeking to dismiss roughly 2 million old minor warrants and citations in the hopes of easing legal burdens on the Los Angeles homeless population.The offices of the Los Angeles district attorney, city attorney and police chief announced the filing of the motions Wednesday, saying they are seeking to reduce the court’s backlog and focus on serious offenses.Homelessness rose 16% in LA over the past year, to more than 36,000 people, according to a June report by the Los Angeles Homeless Services Authority.The city and district attorneys are also seeking to dismiss old fines and fees for minor violations.Los Angeles Police Chief Michel Moore told The Associated Press in July that he considered homelessness to be a “humanitarian crisis of our generation.” 803
LOS ANGELES (AP) — California State Parks officials are trying to solve a stinky mystery: A die-off has left hundreds of fish floating in a recently restored lagoon on the tony Malibu coast.California State Parks Angeles District Superintendent Craig Sap says Monday scientists believe the Malibu Lagoon die-off, which began last Wednesday, is very likely caused by the unusually warm water temperatures.But other possibilities include elevated nutrient levels, dropping levels of dissolved oxygen or having too many fish in the lagoon.Officials are taking water samples and fish for testing.Malibu Lagoon underwent a controversial restoration project in 2013.Sap says officials improved the ecosystem by providing better oxygen levels and the number of fish in the lagoon has since increased. 801
LONDON — People across England face tough new fines if they fail to self isolate after testing positive for COVID-19.Starting Monday, those who fail to follow the rules face a 1,000-pound (,200) fine, which increases to 10,000 pounds for repeat offenders. The Department of Health and Social Care says those who test positive also will be fined if they knowingly provide false information to contact tracers.Health Secretary Matt Hancock says the government will “not hesitate” to introduce further measures to restrict the spread of the coronavirus.The House of Commons on Wednesday may consider an amendment to existing legislation that would give Parliament the right to vote on any new restrictions.Britain already has Europe’s worst death toll from the pandemic, with about 42,000 confirmed deaths. But those who are calling for tighter restrictions are being challenged by critics who fear further damage to the economy.In addition to national restrictions, about one-quarter of the U.K.’s 65 million people are living under tighter local restrictions to fight local outbreaks. 1093
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