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The U.S. will pay drug company Pfizer .95 billion to produce and deliver 100 million doses of the company's COVID-19 vaccine candidate should the drug prove effective in human trials the company said in a press release on Wednesday.Pfizer will deliver the vaccine if and when the drug receives Emergency Use Authorization from the FDA after a large-scale Phase 3 trial.According to the reports, the deal includes an option for the government to purchase an additional 500 million doses of the vaccine.“Expanding Operation Warp Speed’s diverse portfolio by adding a vaccine from Pfizer and BioNTech increases the odds that we will have a safe, effective vaccine as soon as the end of this year,” Health and Human Services Sec. Alex Azar said in a statement. “Depending on success in clinical trials, today’s agreement will enable the delivery of approximately 100 million doses of this vaccine to the American people.”Pfizer and German firm BioNTech are working together to develop the vaccine.On Monday, Pfizer said in a press release that results from Phases 1 and 2 of a German trial indicated that the drug "could potentially be administered safely, with a manageable tolerability profile," according to data from the tests.Biotech company Moderna is also working to develop a coronavirus vaccine. That candidate will move into Phase 3 testing by the end of the month, and the government has also agreed to purchase and distribute the drug should the large-scale test prove effective. 1497

The U.S. recorded more than 120,000 new cases of COVID-19 on Thursday as cases continue to skyrocket across the country.According to Johns Hopkins University, there were 121,888 new cases of COVID-19 recorded across the country on Thursday. That shatters the previous record of 102,000 cases that were reported on Wednesday.Johns Hopkins reports that more than 1,200 people died of the virus in the U.S. on Thursday, the highest death total since Sept. 15. The highest daily death total throughout the pandemic occurred on April 15, when 2,600 people died.According to Johns Hopkins, COVID-19 is currently spreading faster in the U.S. than it is anywhere else in the world. The U.S. has recorded an average of about 80,000 new cases of COVID-19 in the last seven days; the country with the second-highest rate of new cases is India, with an average of about 45,000 new cases of the virus each day.Health officials warn that the U.S. is entering what could be the most dangerous and deadly period of the pandemic, as colder weather forces social gatherings indoors, where the virus is more easily spread.Since the start of the pandemic, there have been 9,606,369 cases reported in the US, 234,911 being fatal. Both totals mark the most of any country. 1258

The U.S. again broke its daily record for new confirmed cases of COVID-19 on Wednesday, as local health departments recorded 50,000 new confirmed cases of the virus, according to a database kept by Johns Hopkins.The previous record was set Tuesday when health departments reported about 45,400 new cases.The figures highlight a continued spike in cases throughout the country over the past few weeks. Prior to the recent peak, the highest daily increase in confirmed cases came on April 24, when health departments reported about 36,400 new cases. The U.S. has recorded at least 38,900 new cases every day for the last week.(John's Hopkins)Because the Johns Hopkins database is reliant on reporting from local health departments, the data doesn't necessarily reflect a patient's day of infection. Daily case numbers are often higher mid-week because some local health departments or test centers may be closed on weekends.It's not just cases that are on the rise. According to the Institute for Health Metrics and Evaluation at the University of Washington, use of hospital beds, ICU beds and invasive ventilators have all risen in recent weeks after months of falling resource use.Many states have either "paused" or chosen to take steps back in their reopening process as cases and hospitalizations linked to the virus continue to rise.On Tuesday, Dr. Anthony Fauci — the government's top expert on infectious diseases — called the recent spike in cases "disturbing," and said that he could foresee the U.S. reporting up to 100,000 new COVID-19 cases a day if recent trends continue. 1593

The Trump administration was moving ahead early Tuesday with the execution of the first federal prison inmate in 17 years after a divided Supreme Court reversed lower courts and ruled federal executions could proceed.Daniel Lewis Lee had been scheduled to receive a lethal dose of the powerful sedative pentobarbital at 4 p.m. EDT Monday. But a court order issued Monday morning by U.S. District Judge Tanya Chutkan prevented Lee’s execution.A federal appeals court in Washington refused the administration’s plea to step in, leaving the hold in place, before the Supreme Court acted by a 5-4 vote. Still, Lee’s lawyers insisted the execution could not go forward after midnight under federal regulations.With conservatives in the majority, the court said in an unsigned opinion that the prisoners’ “executions may proceed as planned.” The four liberal justices dissented.Lee’s execution was scheduled for about 4 a.m. EDT Tuesday, according to court papers.The Bureau of Prisons had continued with preparations even as lower courts paused the proceedings.Lee, of Yukon, Oklahoma, has had access to social visitors, visited with his spiritual adviser and has been allowed to receive mail, prison officials said. The witnesses for Lee are expected to include three family members, his lawyers and spiritual adviser.Lee was convicted in Arkansas of the 1996 killings of gun dealer William Mueller, his wife, Nancy, and her 8-year-old daughter, Sarah Powell.“The government has been trying to plow forward with these executions despite many unanswered questions about the legality of its new execution protocol,” said Shawn Nolan, one of the attorneys for the men facing federal execution.The decision to move forward during a global health pandemic that has killed more than 135,000 people in the United States and is ravaging prisons nationwide, drew scrutiny from civil rights groups as well as family of Lee’s victims.Some members of the victims’ family argued they would be put at high risk for the coronavirus if they had to travel to attend, and sought to delay the execution until it was safer to travel. Those claims were at first granted but also eventually overturned by the Supreme Court.Critics argue that the government is creating an unnecessary and manufactured urgency for political gain. The developments are also likely to add a new front to the national conversation about criminal justice reform in the lead-up to the 2020 elections.Two more executions are scheduled this week, though one, Wesley Ira Purkey, was on hold in a separate legal claim. Dustin Lee Honken’s execution was scheduled for on Friday.A fourth man, Keith Dwayne Nelson, is scheduled to be executed in August.In an interview with The Associated Press last week, Attorney General William Barr said the Justice Department has a duty to carry out the sentences imposed by the courts, including the death penalty, and to bring a sense of closure to the victims and those in the communities where the killings happened.But relatives of those killed by Lee strongly oppose that idea. They wanted to be present to counter any contention that it was being done on their behalf.“For us it is a matter of being there and saying, `This is not being done in our name; we do not want this,’” said relative Monica Veillette.The federal prison system has struggled in recent months to contain the exploding number of coronavirus cases behind bars. There are currently four confirmed coronavirus cases among inmates at the Terre Haute prison, according to federal statistics, and one inmate there has died.Barr said he believes the Bureau of Prisons could “carry out these executions without being at risk.” The agency has put a number of additional measures in place, including temperature checks and requiring witnesses to wear masks.But on Sunday, the Justice Department disclosed that a staff member involved in preparing for the execution had tested positive for the coronavirus, but said he had not been in the execution chamber and had not come into contact with anyone on the specialized team sent to handle the execution.The three men scheduled to be executed this week had also been given execution dates when Barr announced the federal government would resume executions last year, ending an informal moratorium on federal capital punishment as the issue receded from the public domain.Executions on the federal level have been rare and the government has put to death only three defendants since restoring the federal death penalty in 1988 — most recently in 2003, when Louis Jones was executed for the 1995 kidnapping, rape and murder of a young female soldier.In 2014, following a botched state execution in Oklahoma, President Barack Obama directed the Justice Department to conduct a broad review of capital punishment and issues surrounding lethal injection drugs.The attorney general said last July that the Obama-era review had been completed, clearing the way for executions to resume.___Associated Press writers Colleen Long and Mark Sherman in Washington, Michael Tarm in Chicago and Andrew DeMillo in Little Rock, Ark., contributed to this report. 5150

The rise in telemedicine could lead to more problems for people who need to keep an eye on their heart health.A study published by JAMA showed televisits accounted for 35% of primary care cases from April to June. Office-based visits declined by half.The study found blood pressure tests also declined by 50% and cholesterol checks went down by 37%.A doctor with the American Heart Association says that could be the result of the uncertainty surrounding the start of the pandemic.“They were doing the COVID tests in the same place as normal labs, so people were hesitant to go, and when you think of cholesterol panel, its fasting, which means a lot of lab places were getting top heavy with people in the mornings,” said Dr. Reshmaal Gomes, a volunteer with the American Heart Association.Gomes says labs now separate COVID-19 tests from other lab work. She says home lab testing has become more efficient and many insurance companies now pay for it.She says telehealth has also proved to be important for those recovering from heart attacks and strokes.“They have shown that telehealth rehab after a stroke is working and working for patients who would not have been able to make those three or four visits to the physical therapist,” said Gomes.Gomes says people who had blood pressure and cholesterol checks done in between doctor visits reduced their likelihood of a heart related emergency by 50%. 1412