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Maryland-based vaccine developer, Novavax, has received .6 billion from the federal government to complete late-stage clinical development; set up large-scale manufacturing; and deliver 100 million doses of NVX?CoV2373, its COVID-19 vaccine candidate, as early as late 2020.This is the largest vaccine deal to date with the Trump administration as part of their Operation Warp Speed, which is focused on making a COVID-19 vaccine and treatments available as quickly as possible.Novavax has not brought any of their developed vaccines to market. According to information on their website, they have developed several vaccines for infectious diseases, however they are all in various stages of development or clinical trials. These include vaccines for the seasonal flu and RSV. Other vaccines created by Novavax are not actively being developed or studied at this time, including ones for Ebola, MERS, and SARS.According to a statement from Novavax, the agreement with the federal government includes the company demonstrating being able to rapidly get manufacturing and large-scale production of the vaccine going once approved. Novavax hopes to conduct their late-stage clinical study with 30,000 subjects in fall 2020.An early-stage clinical study took place in Australia in May on 130 participants. Study results are expected at the end of July.“Today’s .6 billion investment supports the Novavax candidate, depending on success in clinical trials, all the way through to manufacturing 100 million doses for the American people,” said U.S. Health and Human Services Secretary Alex Azar.Regeneron Pharmaceuticals has also received 0 million through Operation Warp Speed on Tuesday, to make and supply its COVID-19 vaccine candidate, REGN-COV2. Their vaccine is currently in phase 2 and phase 3 clinical studies for the treatment and prevention of COVID-19.Regeneron has several vaccines on the market currently, including Dupixent, used to treat allergic diseases such as eczema, asthma and nasal polyps which result in chronic sinusitis, and Praluent, used to treat high cholesterol. 2101

Maryland Legal Aid is incensed at the treatment of our colleague, Mr. Rashad James, an extremely talented and dedicated civil legal aid attorney, who under MLA's Community Lawyering Initiative, is tasked with navigating every stretch of this state to provide civil legal counsel and representation for Maryland's poorest and most vulnerable individuals and communities. That includes in Harford County, where this deeply disturbing incident unfolded. 458

MAPLE HEIGHTS, Ohio — Maple Heights Mayor Annette Blackwell believes northeast Ohio's shortage of affordable housing is having a tragic impact on the academic development of children. Blackwell told WEWS the affordable housing shortage is causing too many families to move from school district to school district and, in some cases, multiple moves are made in one school year.Blackwell said housing insecurity is playing a major factor in hindering the education of children, especially children from African-American families living in Cleveland and the inner-ring suburbs."It is an issue here in northeast Ohio, it is an issue here in the school district in Maple Heights," Blackwell said. "These children have to deal with the stress when they see their parents negotiating with the landlord, they see mom's rejection, they are part of that rejection when the application gets turned down, or the eviction notice comes.""All of these things add to the heightened sense of anxiety and stress. It's overwhelming on a daily basis."Blackwell pointed to a Harvard Medical School?study indicating that multiple moves contribute to a critical loss of learning.Blackwell said too many families simply can't afford to find good, stable housing."They make between and an hour, they have three kids, they have a car they're trying to maintain and they have to work two jobs to do that," Blackwell said.Professor Ronnie Dunn, Cleveland State University chief diversity and inclusion officer, told WEWS the toxic stress caused by multiple moves and a lack of affordable places to live are hurting young children and families more and more."In Cleveland, we average about 11,000 evictions annually," Dunn said. "A lot of that stems from living in inadequate, poor housing. It has a very dire and adverse effect."Blackwell believes possible solutions include creating tax credits to give developers incentives to create new affordable housing, and municipalities and developers working together to re-purpose existing square footage."There's a lot of ugly empty buildings, gut them," Blackwell said. "There are great architects, there's great brain power, great houses, great vision, and turn it into something livable." 2279

MEXICO CITY (AP) — Mexico is bracing for the possible arrival of the "mother of all caravans," even as doubts arise over whether the group of Central American migrants will be all that big.Interior Secretary Olga Sanchez Cordero has said a caravan of migrants from El Salvador, Honduras and Guatemala could be forming."We have information that a new caravan is forming in Honduras, that they're calling 'the mother of all caravans,' and they are thinking it could have more than 20,000 people," Sanchez Cordero said Wednesday.But a WhatsApp group calling for people to gather Saturday in El Salvador to set off for Guatemala only has about 206 members.Activist Irineo Mujica, who has accompanied several caravans in Mexico, said reports about "the mother of all caravans" were false, claiming "this is information that (U.S. Homeland Security Secretary Kirstjen) Nielsen is using to create fear."His group, Pueblo Sin Fronteras, said in a statement there was no evidence the new caravan would be that large, noting "there has never been a caravan of the size that Sanchez Cordero mentioned." Indeed, past caravans hit very serious logistical hurdles at 7,000-strong.She and others suspect the administration of U.S. President Donald Trump may be trying to fan fears of a big caravan to turn the U.S. national agenda back to the immigration issue.Honduran activist Bartolo Fuentes, who accompanied a large caravan last year, dismissed the new reports as "part of the U.S. government's plans, something made up to justify their actions."A caravan of about 2,500 Central Americans and Cubans is currently making its way through Mexico's southern state of Chiapas. The largest of last year's caravans in Mexico contained about 7,000 people at its peak, though some estimates ran as high as 10,000 at some points.Mexico appears to be both tiring of the caravans and eager not to anger the United States. It has stopped granting migrants humanitarian visas at the border, and towns along the well-traveled route to Mexico City sometimes no longer allow caravans to spend the night.Mexican President Andres Manuel Lopez Obrador said Thursday that Mexico is doing its part to fight immigrant smuggling."We are going to do everything we can to help. We don't in any way want a confrontation with the U.S. government," he said. "It is legitimate that they are displeased and they voice these concerns."Sanchez Cordero has pledged to form a police line of "containment" around Mexico's narrow Tehuantepec Isthmus to stop migrants from continuing north to the U.S. border.The containment belt would consist of federal police and immigration agents, but such highway blockades and checkpoints have not stopped large and determined groups of migrants in the past. 2757

MEXICO CITY (AP) — The Mexican government said Friday it is busing migrants who have applied for asylum in the United States to the southern Mexico state of Chiapas.About 30,000 migrants have been sent back to northern Mexican border cities to await U.S. asylum hearings under a policy known as "Remain in Mexico" under which they have to wait for hearings months away. But few provisions have been made for them to be housed or seek legal representation, and many cities on the northern border are among the most dangerous in Mexico.Mexico's National Immigration Institute said it is uses to move migrants south from Nuevo Laredo and Matamoros — two of the most dangerous cities on the northern border. Both cities are in northern Tamaulipas state across from Texas and are dominated by drug cartels.The migrant agency said the goal of the busing is "to provide a safer alternative for those who do not want to remain on the U.S.-Mexico border." It did not say how many people had been taken by bus to Chiapas so far.The Associated Press reported that in July, Mexico had begun busing some of the returned migrants out of Tamaulipas to the city of Monterrey, in neighboring Nuevo Leon state. Authorities said it was for their safety, but many were dropped off in that unfamiliar city in the middle of the night.Officials gave no indication of how the migrants would return to the border from Monterrey for their court dates. That problem would be amplified for migrants bused to Chiapas, nearly all the way back to the Guatemala border. 1545

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