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Drugmaker Bristol-Myers Squibb announced Thursday a billion deal to buy Celgene, in one of the biggest mergers in pharmaceutical industry history.The deal, which still needs the approval of shareholders and regulators, will be paid with a combination of stock and cash. Bristol-Myers is the result of a 1989 merger of two companies that traced their roots back to the 19th century, and is the eighth largest US drugmaker, with annual revenue of .8 billion in 2017. Celgene is the ninth largest with revenue of billion.The combined company could become the fourth largest pharmaceutical company in the United States.Shares of Bristol-Myers ( 663

CLEVELAND — Dry eye condition occurs when there aren’t enough tears to lubricate the eye. If not treated, it can lead to other serious infections in the eye, and although it is managed, it can never be fully eliminated. It’s typically a diagnosis for older patients, but doctors are noticing a change.“Twenty-two years ago, when I started, most of the patients with dry eye disease were the pre-menopausal females or patients who were on significant medications, like antihistamines, that dried their eyes out,” said Dr. Tom Chester of the Cleveland Eye Clinic. But Chester says that’s not the case anymore.“We are seeing a preponderance in younger patients,” he said. “Maybe patients in their 20s, 30s, even teenagers. Actually, the youngest patient I’ve treated was an 8-year-old with dry eye disease.” He attributes the shift of younger and younger patients to increased screen time.“One of the biggest aspects about tablets and phones is that the patients don't blink, and so when they're not blinking, they're not causing the ocular surface to utilize the glands to produce a good tear film,” said Chester.That can lead to other conditions, like infections and scarring.Chester says it’s up to parents and caregivers to make sure kids are blinking when they’re using electronics. Experts suggest limiting screen time.“The one thing about children and teens, in particular, is they don’t typically complain about their eye health. So, it’s important for parents or caregivers to watch or pay attention to the children, or even teachers to pay attention. If they see a lot of eye rubbing, if they see a lot of blinking, or squeezing, it could be because the surface is irritated, and the children don’t know any different, so they don’t know how to necessarily say ‘My eyes are dry,’ ” Chester said.He doesn’t anticipate this trend of younger kids diagnosed with the condition to go anywhere, anytime soon. 1921

Every county in Florida is under a state of emergency as the state prepares for what may be the strongest hurricane to hit its east coast in nearly three decades.At 105 mph, Dorian is the strongest storm of the Atlantic hurricane season so far. If it makes landfall as a 283

Commercial airlines are rerouting flights throughout the Middle East to avoid potential danger during heightened tensions between the United States and Iran.Jumbled schedules could affect as many as 15,000 passengers per day, lengthen flight times by an average of 30 to 90 minutes, and severely bruise the bottom line for airlines, industry analysts said.There is anxiety that the conflict between the longtime foes could intensify following Iranian ballistic missile strikes Wednesday on two Iraqi bases that house U.S. troops. The attacks were retaliation for the U.S. killing of Iranian Revolutionary Guard Gen. Qassem Soleimani in a drone strike near Baghdad last week.“In a war situation, the first casualty is always air transport,” said Dubai-based aviation consult Mark Martin, pointing to airline bankruptcies during the Persian Gulf and Yugoslav wars.At least 500 commercial flights travel through Iranian and Iraqi airspace daily, Martin said.A Ukrainian passenger jet crashed shortly after taking off from Iran’s capital Wednesday killing 167 passengers and nine crew members just hours after 1118

Dollar General keeps expanding even as discount rivals like Family Dollar shrink.The company said Thursday it will open 975 new stores in the United States this year. Dollar General will remodel 1,000 older stores with new queue lines to drive last-minute impulse buys. It will also spruce up its health and beauty sections to lift sales.Dollar General has been growing for years in rural America. Dollar General opened 432