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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789
SAN DIEGO (CNS) - Father Joe's Villages announced Friday that it has established an emergency fund to raise money for the homeless during the COVID- 19 crisis. With its thrift and donation stores shuttered, and donation pick-ups and drop-offs on hiatus as part of the shelter's efforts to reduce the risk of spreading the virus to clients and staff, Father Joe's representatives say the new fund will be crucial to continue to provide shelter, health care, food, showers and laundry for those in need. Qualcomm co-founder Franklin Antonio has provided a 0,000 matching gift challenge in an effort to encourage monetary support from the community, Father Joe's Villages said. Donations can be made online here.While some services have been paused in the wake of the coronavirus outbreak, Father Joe's Villages reiterated there are no confirmed COVID-19 cases at the shelter.One client showed signs of COVID-19 symptoms on Wednesday, leading to a temporary interruption in intakes. However, the client was tested for COVID- 19 and was confirmed negative for the virus Thursday, leading the shelter to resume accepting intakes following direction from county officials. 1177

SAN DIEGO (CNS) - Countywide sales of previously owned single-family homes and attached properties like condominiums increased from June to July while median sale prices ticked down, according to data released Wednesday by the Greater San Diego Association of Realtors.Single-family home sales rose 2.4%, from 1,980 in June to 2,028 in July, while attached property sales ticked up 5.1%, from 975 in June to 1,025 last month. Both increases are a modest recovery for the housing market after housing sales tumbled by double digits from May to June.Median sales prices for both property types dipped slightly in July after steady gains each month of the year, save for attached property prices from March to April. Single-family home prices decreased 2.2% from 0,000 in June to 5,000 in July, while attached property prices dipped 1.5% from 1,500 in June to 5,000 last month.``The inventory of homes for sale across the county just can't seem to jump-start, although some neighborhoods have been consistently strong,'' said SDAR President Kevin Burke. ``We can be thankful for the continuing economic expansion, low mortgage rates and the recent reduction in the benchmark interest rate by the Fed.''Year-over-year sales declined for both property types, according to the GSDAR. Single-family home sales dipped 3.3% in July when compared to a year ago -- from 2,097 to 2,028, while attached property sales fell 2.8% from 1,055 in July 2018 to 1,025 last month.Year-over-year sales prices increased slightly for both property types. Single-family sales prices ticked up 0.6% from 1,000 in July 2018 to 5,000 last month, while attached property prices increased 1.2% from 0,000 in July 2018 to 5,000 last month.Fifty-eight single-family homes sold in Fallbrook last month, the most of any ZIP code in the county. 1841
SAN DIEGO (CNS) - An elderly disabled woman was assaulted and seriously injured in downtown San Diego, police said Saturday.The victim, a 73-year-old homeless woman who uses a walker, was attacked near the corner of Fourth Avenue and B Street at 10:10 p.m. Friday, according to Lt. Matt Dobbs of the San Diego Police Department's homicide unit.She was taken to the hospital where she underwent emergency surgery, the lieutenant said. Because of the serious nature of the woman's injuries, investigators from the SDPD's homicide unit were called to the scene."Detectives are collecting evidence and interviewing witnesses," Dobbs said. "A man was seen in an altercation with the victim. He is described as a Black male in his forties, approximately six-feet tall and weighing 250 pounds."The suspect was wearing a white tank top and blue jeans and was last seen walking eastbound on 400 C Street, Dobbs said.The victim has been identified, but her name was not immediately released.Anyone with information on the attack was asked to call the homicide unit at 619-531-2293 or Crime Stoppers at 888-580-8477. 1113
SAN DIEGO (CNS) - An alleged drunken driver accused of running over and fatally injuring a co-worker, who was trying to prevent her from driving home following a night out in Kearny Mesa, was charged Tuesday with murder, gross vehicular manslaughter while intoxicated and hit-and-run causing death. Latisha Ingram, 33, is accused in the death last Thursday night of 25- year-old Ha Minh Ta.Deputy District Attorney Phillippa Cunningham said Ingram was charged with second-degree murder because she has a 2010 DUI conviction in Orange County.According to the prosecutor, Ingram and Ta met up with other co-workers for after-dinner drinks and the defendant, ``against the advice of friends,'' decided to try and drive home.RELATED: San Diego police: Man run over, killed after argument in Kearny Mesa parking lotIngram got into an argument with Ta about 11:30 p.m. in a parking lot in the 4600 block of Convoy Street, and she allegedly started to drive away while he was still holding onto her car. Ingram drove out of the parking lot and turned southbound onto Convoy Street, where Ta let go and was run over by the defendant, San Diego police Officer Robert Heimsthe officer alleged.Paramedics rushed Ta to a hospital, where he died from his injuries. Ingram was arrested a short time later.Laboratory tests are pending to determine her blood-alcohol content at the time of her arrest, Cunningham said.San Diego Superior Court Judge Jay Bloom set bail at .5 million for Ingram, who pleaded not guilty to the charges and s set to return to court July 15 for a readiness conference. 1590
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