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WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

YUEYANG, Hunan, June 2 (Xinhua) -- The population of finless porpoises, an endangered species of freshwater dolphin that lives in China's Yangtze River, may decrease by over 80 percent over the next 30 years, experts said on Thursday after conducting a field survey along the river.The rare species will edge closer to extinction if no action is taken, said Wang Ding, a dolphin expert from the Hydrobiology Institute of the Chinese Academy of Sciences.Wang's team conducted a survey on Poyang Lake, Dongting Lake and other locations along the Yangtze from Sunday to Wednesday this week.The dolphin population currently stands at 1,000, even lower than that of the giant panda, Wang said.The dolphin population is decreasing by a rate of 6.4 percent annually, Wang said."The next ten years will be a critical period for the conservation of this species," Wang said.A long-lasting drought in central China has lowered water levels in many of the region's lakes and rivers, doing great harm to the dolphins' habitat and leading to a decrease in population, Wang said.Mei Zhigang, a member of Wang's survey team, said that human activity has also contributed to the dropping population.Mei said that large numbers of shipping vessels on the Yangtze have impeded the dolphins' migration path, causing them to reproduce less frequently.

SAN FRANCISCO, Sept. 6 (Xinhua)-- Yahoo on Tuesday fired Chief Executive Officer Carol Bartz and replaced her temporarily with the company's chief financial officer."On behalf of the entire board, I want to thank Carol for her service to Yahoo during a critical time of transition in the company's history, and against a very challenging macro-economic backdrop," said Yahoo Chairman Roy Bostock in a news release.The Yahoo Board of Directors appointed CFO Timothy Morse as interim CEO who will manage the company's day-to-day operations until a permanent chief executive is chosen.Carol Bartz, chief executive of Internet company Yahoo Inc, is shown in this undated publicity photo released to Reuters January 13, 2009. Before Yahoo's formal announcement, several news organizations and tech blogs posted an email reportedly from Bartz sent from her iPad to all employees of the company."To all, I am very sad to tell you that I've just been fired over the phone by Yahoo's Chairman of the Board. It has been my pleasure to work with all of you and I wish you only the best going forward."Bartz, 63, took over the Yahoo CEO role from co-founder Jerry Young in January 2009, when the company was struggling to stay competitive and profitable in a market dominated by Google. However, Yahoo never reached the heights she had foreseen.In the most recent quarterly earnings report in June, Yahoo reported net revenue of 1.1 billion U.S. dollars, down 5 percent from last year.Morse, 42, was hired as executive vice president and CFO at Yahoo in July 2009. "It is an honor to be selected for this role," he said in a statement Tuesday.Yahoo said it is starting a search for a new permanent CEO and plans to hire a "nationally recognized executive search firm" to assist in the effort.

SAN FRANCISCO, June 14 (Xinhua) -- Apple updated its online store on Tuesday to begin offering unlocked models of iPhone 4 in the United States for the first time."The unlocked iPhone 4 requires an active micro-SIM card that you obtain from a supported GSM wireless carrier," said Apple in the product description. The iPhone requires a smaller version of the standard SIM (Subscriber Identity Module) card.Started at 649 U.S. dollars for the 16 GB version, the unlocked model is a GSM phone, which means, in the United States, the phone runs on networks of T-Mobile or AT&T, although it can only send data over T-Mobile's old EDGE network, not its 3G network and the faster HSPA+ network.Verizon and Sprint, the other two major U.S. wireless carriers, both use CDMA networks that do not use SIM cards.The iPhone 4 has been sold unlocked in other countries. For frequent international travelers, an unlocked iPhone means they just need to pop in a micro-SIM card for whichever country they are going, avoiding provider's high international fees.According to Apple, iPhone sales grew 113 percent year over year in the second quarter of its fiscal 2011, reaching a record high of 18.65 million units.

BEIJING, Aug. 23 (Xinhuanet) -- More than 90 percent of U.S. heart attack patients who need the lifesaving procedure receive it within just 90 minutes of being admitted to the hospital, according to a study released Monday in the journal Circulation.The study on the American Heart Association's journal shows that in 2010, 91 percent of heart attack patients who needed angioplasty were treated within the 90-minute window. While in 2005, 44% were.Researchers analyzed data on more than 300,000 such patients who underwent emergency angioplasty between January of 2005 and October of 2010.The improvement is the result of a nationwide effort between federal agencies, health care organizations and health care providers to improve heart attack care and outcome, said study author Dr. Harlan M. Krumholz, a professor of medicine and epidemiology and public health at Yale University School of Medicine, according to U.S. News reports.