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On Monday morning, Pfizer announced that so far in Phase 3 trials, its COVID-19 vaccine candidate has been 90% effective in promoting protection against the virus. And while the announcement has many Americans seeing the light at the end of the tunnel, the pandemic is still far from over.Pfizer's announcement on Monday is an encouraging sign, as it means that the company is on track to file for Emergency Use Authorization for the vaccine in the coming weeks. It also keeps the U.S. on a timeline to have at least one vaccine approved and available for distribution by the end of 2021.But Monday's announcement does not mean a vaccine is imminent. Pfizer is currently mass-manufacturing its vaccine candidate in the event it does receive Emergency Use Authorization from the FDA, and hopes to have 100 million doses of the vaccine ready to ship by year's end. But even if Pfizer is able to fulfill that ambitious order by Dec. 31, it would only be able to vaccinate about one-third of everyone in the county.Once the initial vaccine order has been completed, it will need to be rationed for those who need it most — likely health care workers, essential employees and people in high-risk populations. While it is unclear who exactly will be eligible to receive the vaccine first, the Department of Health and Human Services (HHS) says the early distribution of a COVID-19 vaccine will be "constrained tightly" and will be "highly targeted" to "achieve coverage in priority populations."Eventually, the U.S. hopes to grant emergency use authorization to several vaccine candidates — many of which are currently in production on orders from the U.S. government. HHS hopes that by the middle of next year, several vaccines will be approved and widely available. But at that point, officials will run into a second major hurdle — vaccine skepticism.Skepticism about vaccines has been on the rise in recent years, fueled in part by the spread of misinformation online. In particular, baseless conspiracies linking vaccines to autism have spread on social media, eroding public confidence in medicine. In addition, polarized politics in the U.S. have led to speculation that government leaders will approve an unsafe or ineffective vaccine for political purposes.Vaccines are only effective if enough members of the public become inoculated against a virus — if a virus has nowhere to spread, it will eventually die out. But Gallup polling released in October shows that just 50% of Americans say they would receive a COVID-19 vaccine if it had been approved by the FDA and available at no cost — far below the threshold for herd immunity, according to many health experts.The Gallup polling is consistent with AP polling from earlier this year that also only found 50% willingness to take a COVID-19 vaccine.All the while, the final push for a COVID-19 vaccine will be occurring during what members of the White House coronavirus task force warn will be the most concerning and deadly period of the pandemic. The virus is currently spreading in the U.S. faster than it has at any other point during the pandemic, just as Americans are moving social gatherings indoors where the virus is more likely to spread.To be clear, health officials' efforts to develop a safe and effective COVID-19 is a momentous and historic achievement — approving a vaccine for emergency use by the end of the year would shatter all previous records for vaccine development. But while there may be light at the end of the tunnel, it may take several months — or years — to reach the end of the pandemic. 3586

OCEANSIDE (CNS) - Two vehicles crashed Saturday on College Boulevard underneath state Route 78 in Oceanside, killing at least one person.The California Highway Patrol reported a blue Tesla and red sedan collided at 3:04 p.m., causing one of them to overturn and land on its roof on College.Medics and officers from the Oceanside Police Department were on scene trying to extract the two occupants of the overturned vehicle, the CHP said. Officers were shutting down traffic in the area.A San Diego County coroner was at the scene of the crash to investigate, the CHP said.No further information was immediately available. 629

NYE COUNTY, Nevada — Famed Love Ranch brother owner and GOP Assembly candidate Dennis Hof has died.The Nye County Sheriff's Office confirmed Hof's death Tuesday morning at the Love Ranch in Crystal, outside of Pahrump. Detectives and deputies are currently on scene and conducting an investigation into his death. Hof was 72 years old. His cause of death is unknown at this time.  Hof's campaign manager Chuck Muth first tweeted about his death.  489

OCEANSIDE, Calif. (KGTV) -- A woman was arrested in Oceanside after trying to smuggle methamphetamine with her 7-year-old in the car. Border Patrol agents pulled the woman over near the Oceanside Harbor Interstate 5 exit just after 4 p.m. Tuesday. After becoming suspicious of the driver’s behavior, agents found more than 48 pounds of the drug inside a duffle bag in the trunk. RELATED: Woman tries to smuggle drugs into the U.S. with five kids in van, CBP saysThe drugs, according to Border Patrol, have an estimated street value of more than ,000. The 26-year-old driver, a Mexican national with a valid tourist visa, was arrested for felony drug trafficking. The minor child was placed in the care of local child protective services. RELATED: Border Patrol finds drugs hidden in child's car seatSince Oct. 1, 2019, the agency says it has seized more than 750 pounds of methamphetamine worth more than ,427,000. 928

On Monday, drugmaker Moderna offered renewed hope that the COVID-19 pandemic could soon end when it announced that is vaccine candidate was 95% effective in Phase 3 clinical trials.The announcement marked a resounding success for dozens of researchers, doctors, scientists and health experts who have worked tirelessly for months in the hopes of producing a viable vaccine — and among those credited with helping to fund the research was beloved country singer and philanthropist Dolly Parton.In April, Parton announced that she was making a million donation to the Vanderbilt University Medical Center that was earmarked for COVID-19 research. The team at Vanderbilt has worked with Moderna throughout its development process and helped conduct vaccine trials for people in the Nashville area."This is an exciting time for us in vaccines because it shows us that both of the vaccines that we've evaluated so far, one from Pfizer and one from Moderna has shown themselves to be effective when given in these phase three trials," said Dr. Buddy Creech, the director of Vanderbilt's Vaccine Research Program. "So, it gives us a lot of confidence that not only are these vaccines successful, but other vaccines that are built similarly will have the same level of success." 1281

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