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Scientists are working to eliminate a type of heart disease in dogs using gene therapy. They're zoning in on a heart condition called mitral valve disease that’s common in 6% of dogs. Scientists are using Cavalier King Charles spaniels for the research. They tend to develop it at a younger age. Scientists at Tufts University have already tested gene therapy in mice. A virus is injected into them to deliver DNA to cells which causes them to create a protein. What it essentially does is stops the heart valve from getting thicker, stopping the valve from leaking. Researchers are now moving on to testing this in dogs. But they think the treatment could go beyond just canines. “Many of the dog diseases are naturally occurring and really great models for human disease,” says Dr. Vicky Yang, a veterinary cardiologist and research assistant professor at Cummings School of Veterinary Medicine at Tufts University. “And I can see this, if it becomes successful in dogs, potentially going into thinking about treatment for humans for mitral valve disease.”The biotech company behind the treatment agrees. It says it could also expand beyond heart problems. “I think a larger question, though, is if we are able to prove this thesis of treating aging, making the animal generally healthier, could also treat heart failure, what other diseases could we treat in dogs?” says Daniel Oliver, the CEO of Rejuvenate Bio. “And could we progress this treatment onto past dogs and other animals and possibly humans?” The gene therapy would only be used for dogs just starting to experience heart problems.Researchers still need to make sure the gene therapy is safe for all breeds before they make it available to the public. 1730

The FBI is investigating a possible pawn shop theft ring involving Amazon delivery drivers and thousands of packages containing stolen merchandize sent across the country. The years-long organized theft ring generated more than million, the FBI claims in a July search warrant recently unsealed. News of the warrant was first reported by the Associated Press. Two Washington state pawn shops allegedly bought products from shoplifters who “primarily steal from brick-and-mortar retail stores,” including Home Depot, Lowes, Fred Meyer, the document says. The thieves also paid cash for stolen property from delivery drivers, who stole from Amazon.com and from drug addicts and users, FBI agent Ariana Kroshinsky alleges in the search warrant granted by a judge in the Western District of Washington. The stolen items were then believed to have been stored in Kent, Washington or in Amazon fulfillment centers elsewhere in the country. “The value of property involved in this case has reached well into the millions of dollars since this criminal activity began,” Kroshinsky said. The criminal activity started in about 2012, she said. Law enforcement watched the pawn shops over several weeks in mid-2018, using surveillance and pole cameras. No charges have been filed in this case, and because of that, Scripps is not using the names of the pawn shops or the suspects. Among the items thought to have been stolen and offered for resale are box electronics, gaming systems, computer products, tools, kitchenware, sporting goods and sewing machines, Auburn police discovered. The police department first started the investigation. Later the FBI discovered other stolen items included vitamin and health supplements, over-the-counter medication, makeup, perfume, pet supplies, sports equipment, car products and clothing. Some of the items were stolen by a man, who moved Amazon customer returns from the main airport near Seattle. The items stolen by one person were estimated to be worth about 0,000. Investigators discovered some people were frequently selling items to the pawn shops thought to be involved in the crimes. One person pawned items 16 times in a one-month period. At one point, undercover investigators went into one of the pawn shops in Auburn. “They noticed the lobby areas of the store has no shelves and there was no merchandise displayed for sale to the public,” the search warrant request read. It did not appear the shop “was selling anything from the store, but instead was purchasing products from people coming into the store and then sending the products elsewhere.” Investigators watched, at one point, two transient men pawn brand-new canisters of Similac baby formula. “The detectives found it odd that two apparently transient men would have several brand-new canisters of baby formula, and that a pawn shop would be interested in buying these items,” Kroshinsky wrote. Agents said the online accounts believe to be linked to the pawn shop has items for sale on Amazon.com in fulfillment centers in Fort Worth, Texas, Baltimore, Maryland, Robbinsville, New Jersey, San Bernardino, California and Middletown, Delaware. An investigator from the United States Postal Inspection Service determined 10,071 parcels of mail had been mailed from the Kent area to addresses in the United States in a less than two-month period ending June 21, 2019. 3407

A man in Louisville was shot and killed Monday morning when police officers and members of the National Guard say they "returned fire" while clearing a parking lot of people breaking curfew.Louisville Police Chief Steve Conrad confirmed the shooting happened around 12:15 a.m. Monday in the parking lot of a business on West Broadway. He said officers and the National Guard were called to break up a large group of people who had gathered there after the city's curfew when someone fired a shot at them.Conrad did not specify whether it was a police officer or a military member that fired the fatal shot. No information about the deceased man has been released.It’s unclear if the person killed was the one who fired at law enforcement.According to 763

Safety concerns are arising about yet another piece of furniture sold by major retailers like Amazon, Walmart, Sears and Home Depot. 146

(WKMG/CNN) -- A 42-year-old Orlando woman is facing murder charges after authorities say she zipped up her boyfriend inside a suitcase.Deputies responded Monday after Sarah Boone reported Jorge Torres, 42, was dead.She told police she put him in the suitcase during a game of hide-and-seek.Boone said they were drinking alcohol, and she passed out in her bed while he was still in the suitcase.But deputies searched her phone and found videos showing Torres yelling he couldn't breathe from inside the suitcase.Boone can be heard laughing and saying, "that's what I feel like when you cheat on me" and yelling obscenities.She is facing second-degree murder charges. 677

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