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Here we go...first up is @minakimes and a half-eaten football. Please reply and tag with the charity that you are donating to!!! More to come! pic.twitter.com/q8BuYuutbr— Joe Buck (@Buck) March 24, 2020 215

First came a high fever, drenching sweats and muscle aches. Then, almost a month later, a weird numbness that spread down the right side of her body.Darlene Gildersleeve thought she had recovered from COVID-19. Doctors said she just needed rest. And for several days, no one suspected her worsening symptoms were related — until a May 4 video call, when her physician heard her slurred speech and consulted a specialist.“You’ve had two strokes,” a neurologist told her at the hospital. The Hopkinton, New Hampshire, mother of three is only 43.Blood clots that can cause strokes, heart attacks and dangerous blockages in the legs and lungs are increasingly being found in COVID-19 patients, including some children. Even tiny clots that can damage tissue throughout the body have been seen in hospitalized patients and in autopsies, confounding doctors’ understanding of what was once considered mainly a respiratory infection.“I have to be humble and say I don’t know what’s going on there, but boy we need to find that out because unless you know what the pathogenic (disease-causing) mechanism is, it’s going to be tough to do intervention,” Dr. Anthony Fauci, the nation’s top infectious disease expert, remarked during a medical journal interview last month.Doctors and scientists at dozens of hospitals and universities around the globe are seeking answers while trying to measure virus patients’ risks for clots and testing drugs to treat or prevent them.Gildersleeve said health authorities “need to put out an urgent warning about strokes” and coronavirus. Not knowing the possible link “made me doubt myself” when symptoms appeared, she said.Some conditions that make some COVID-19 patients vulnerable to severe complications, including obesity and diabetes, can increase clot risks. But many authorities believe how the virus attacks and the way the body responds both play a role.“COVID-19 is the most thrombotic (clot-producing) disease we’ve ever seen in our lifetime,” said Dr. Alex Spyropoulos, a clot specialist and professor at Feinstein Institutes for Medical Research in Manhasset, New York.Clotting has been seen in other coronavirus infections, including SARS, but on a much smaller scale, he said.Scientists believe the coronavirus enters the body through enzyme-receptors found throughout the body, including in cells lining the inside of blood vessels. Some theorize that it may promote clotting by somehow injuring those vessels as it spreads. That injury may cause a severe immune response as the body tries to fight the infection, resulting in inflammation that may also damage vessels and promote clotting, said Dr. Valentin Fuster, director of Mount Sinai Heart hospital in New York.It’s unclear how many COVID-19 patients develop clots. Studies from China, Europe and the United States suggest rates ranging from 3% to 70% of hospitalized COVID-19 patients; more rigorous research is needed to determine the true prevalence, the National Institutes of Health says.Prevalence in patients with mild disease is unknown and the agency says there isn’t enough evidence to recommend routine clot screening for all virus patients without clotting symptoms, which may include swelling, pain or reddish discoloring in an arm or leg.Some hospitals have found 40% of deaths in COVID-19 patients are from blood clots. Spyropoulos said that’s been true at his 23-hospital system in the New York City area, Northwell Health, which has treated over 11,000 COVID-19 patients.Cases there have dropped by almost half in the past month, allowing more time for research before an expected second and maybe third wave of infections, he said, adding: “We’re racing against time to answer the key clinical questions.”Patients hospitalized with any severe illness face increased risks for clots, partly from being bedridden and inactive. They commonly receive blood-thinning drugs for prevention. Some doctors are trying higher-than-usual doses for prevention in hospitalized coronavirus patients.A few have used powerful clot-busting medicines typically used to treat strokes, with mixed results. In guidance issued May 12, the NIH said more research is needed to show whether that approach has any benefits.Fuster was involved in preliminary research on nearly 2,800 COVID-19 patients at five hospitals in the Mount Sinai system. A look at their outcomes suggests slightly better survival chances for virus patients on ventilators who received blood thinners than among those who didn’t. Although the results are not conclusive, all COVID-19 patients at Mount Sinai receive blood thinners for clot prevention unless they are at risk for bleeding, a potential side effect, Fuster said.Some COVID-19 patients, like Gildersleeve, develop dangerous clots when their infections seem to have subsided, Spyropoulos said. Patients treated at Northwell for severe disease are sent home with a once-a-day blood thinner and a soon to be published study will detail their experiences. Spyropoulos has been a paid consultant to Janssen Pharmaceuticals, makers of Xarelto, the drug’s brand name.In addition, Northwell is taking part in a multi-center study that will test using blood thinners for clot prevention in COVID-19 patients not sick enough to require hospitalization.In a small study published May 15, University of Colorado doctors found that combined scores on two tests measuring clotting markers in the blood can help determine which patients will develop large dangerous clots. One test measures a protein fragment called D-dimer, a remnant of dissolved clots. High levels sometimes indicate dangerous clots that form deep in leg veins and travel to the lungs or other organs.Dr. Behnood Bikdeli of Columbia University’s Irving Medical Center, said D-dimer levels in many of his COVID-19 patients have been alarmingly high, as much as 50 times higher than normal.Concerns about blood clots in COVID-19 patients prompted a recent 30-page consensus statement from an international group of physicians and researchers. Bikdeli is the lead author.It says that testing to find clots that require treatment includes X-rays or ultrasound exams, but poses a risk for health care workers because the virus is so contagious. Bikdeli said he fears when protective gear was more scarce, some dangerous clots were undiagnosed and untreated.Social distancing may make people more sedentary and more vulnerable to clots, particularly older adults, so doctors should encourage activity or exercises that can be done in the home as a preventive measure, the statement says.Warnell Vega got that advice after collapsing at home April 19 from a large clot blocking a lung artery. Doctors at Mount Sinai Morningside think it was coronavirus-related. Vega, 33, a lunch maker for New York City school children, spent a week in intensive care on oxygen and blood thinners, which he’s been told to continue taking for three months.“I just have to watch out for any bleeding, and have to be careful not to cut myself,” Vega said.Gildersleeve, the New Hampshire stroke patient, was also sent home with a blood thinner. She gets physical therapy to improve strength and balance. She still has some numbness and vision problems that mean driving is out, for now.Doctors are unable to predict when or whether she’ll regain all her abilities.”I’m trying to remain positive about recovering,” she said. ’’I just have to be patient and listen to my body and not push too hard.”___Follow AP Medical Writer Lindsey Tanner at @LindseyTanner.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’ 7639

Former Special Counsel Robert Mueller told Congress on Wednesday that his investigation did not "totally exonerate" President Donald Trump as the President has claimed."The finding indicates that the President was not as exculpated for the acts that he allegedly committed," Mueller said. "It is not what the report said."But beyond that response, Mueller's exchanges with lawmakers were at times shaky, with answers that were often halting and stilted in the face of rapid-fire questions. Mueller frequently referred them back to the report, asked for questions to be repeated and answered with short "true" or "that's correct" responses.Mueller is testifying at the most highly anticipated hearing of the Trump presidency, with the potential to reset the narrative about his two-year investigation into the President's conduct.After weeks of negotiations, twists and turns over Mueller's appearance and a pair of subpoenas, the former special counsel is now answering questions about his probe for the first time before the House Judiciary Committee, and will appear at noon ET before the House Intelligence Committee.The former special counsel's testimony is the closest thing to a make-or-break moment as it gets for Democrats in their investigations into the President. It's a potential turning point for the House Democratic impeachment caucus that's banking Mueller can reset the conversation about the special counsel investigation and convince the public -- and skeptical Democratic colleagues -- that the House should pursue an impeachment inquiry into Trump.Democrats have pointed to Mueller's report as a reason to take up impeachment, but he declined to engage on the question."Is it true that there's nothing in Volume II of the report that says the President may have engaged in impeachable conduct?" asked Rep. Jim Sensenbrenner, a Wisconsin Republican."We have studiously kept in the center of our investigation, our mandate," Mueller responded. "And our mandate does not go to other ways of addressing conduct. Our mandate goes to what — developing the report and turning the report into the attorney general."Democrats walked Mueller through the key passages of his report, while Republicans sought to undercut the special counsel investigation, raising questions about his decision to write a lengthy report about the President's conduct when he did not decide to prosecute the Trump on obstruction of justice."Volume two of this report was not authorized under the law," charged Rep. John Ratcliffe, a Texas Republican and a former prosecutor. "I agree with the chairman, this morning, when he said Donald Trump is not above the law. He's not. But he damn sure shouldn't be below the law, which is where this report puts him."In his opening statement, Mueller defended the work that his team did."My staff and I carried out this assignment with that critical objective in mind: to work quietly, thoroughly, and with integrity so that the public would have full confidence in the outcome," Mueller said.But Mueller also telegraphed that he would not engage on many of the questions both Democrats and Republicans will want him to answer, from the origins of the investigation to how he decided whether or not to prosecute the President."As I said on May 29: the report is my testimony. And I will stay within that text," Mueller said.Even if there isn't a bombshell revelation, Democrats are hopeful that the recitation of the key points of Mueller's investigation and what it uncovered about the President can move the needle."Although Department policy barred you from indicting the President for this conduct, you made clear that he is not exonerated. Any other person who acted this way would have been charged with a crime. And in this nation, not even the President is above the law," House Judiciary Chairman Jerry Nadler said in his opening statement."We will follow your example, Director Mueller. We will act with integrity. We will follow the facts where they lead. We will consider all appropriate remedies. We will make our recommendation to the House when our work concludes," Nadler added. "We will do this work because there must be accountability for the conduct described in your report, especially as it relates to the President."But if Mueller's testimony fails to shift the conversation, it could spell the beginning of the end for 4385

I don’t want to believe thisCoronavirus: Chef Floyd Cardoz, co-owner of Bombay Canteen, dies of Covid-19 in New York City https://t.co/4wqWaYcA0a— Dave Chang (@davidchang) March 25, 2020 199

He's the most popular figure in the Democratic Party by far, revered by liberals, moderates and even some Republicans.But former President 151