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WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

BUJUMBURA, May 31(Xinhua) -- As the World No Tobacco Day is celebrated on Tuesday, many Burundians feel happy that they have given up smoking thanks to herbal drugs.Evariste Ndikumwami, 55, residing in the Burundian capital Bujumbura, said he had been smoking for 30 years, but gave up smoking in January after taking herbal drugs prescribed by an abbot."I had been smoking since my teenage and I gave up smoking in January (this year) after I took herbal drugs that I got from a Roman Catholic priest from Uganda working at Rugari parish in the province of Muyinga, some 210 km northeast of the Burundian capital Bujumbura," Ndikumwami told Xinhua.Ndikumwami said he used to smoke a pack of 20 cigarettes per day, adding that he had found it hard to give up smoking.He said, "I took the herbal drugs for 15 days. The abbot prescribed me two herbal drugs -- one to be smoked for five days at daytime when I desire to smoke and another one to be applied around the nostrils at night."After the medication period, he never felt the desire for smoking cigarettes, he said."When my friends realized I was no longer smoking, they asked me which drugs I took to give up smoking. I directed them to the abbot who had healed me and they also got cured and stopped smoking," Ndikumwami said.

LOS ANGELES, July 22 (Xinhua) -- Two teams of astronomers have discovered the largest and farthest reservoir of water ever detected in the universe, NASA's Jet Propulsion Laboratory (JPL) said on Friday.The water, equivalent to 140 trillion times all the water in the world's ocean, surrounds a huge, feeding black hole, called a quasar, more than 12 billion light-years away, according to JPL in Pasadena, California."The environment around this quasar is very unique in that it's producing this huge mass of water," said Matt Bradford, a scientist at JPL. "It's another demonstration that water is pervasive throughout the universe, even at the very earliest times. "This artist's concept illustrates a quasar, or feeding black hole, similar to APM 08279+5255, where astronomers discovered huge amounts of water vapor. Gas and dust likely form a torus around the central black hole, with clouds of charged gas above and below. X-rays emerge from the very central region, while thermal infrared radiation is emitted by dust throughout most of the torus. While this figure shows the quasar's torus approximately edge-on, the torus around APM 08279+5255 is likely positioned face-on from our point of view.A quasar is powered by an enormous black hole that steadily consumes a surrounding disk of gas and dust. As it eats, the quasar spews out huge amounts of energy. Both groups of astronomers studied a particular quasar called APM 08279+5255, which harbors a black hole 20 billion times more massive than the sun and produces as much energy as a thousand trillion suns.Astronomers expected water vapor to be present even in the early, distant universe, but had not detected it this far away before. There's water vapor in the Milky Way, although the total amount is 4,000 times less than in the quasar, because most of the Milky Way's water is frozen in ice. Water vapor is an important trace gas that reveals the nature of the quasar. In this particular quasar, the water vapor is distributed around the black hole in a gaseous region spanning hundreds of light-years in size (a light-year is about six trillion miles).Its presence indicates that the quasar is bathing the gas in X- rays and infrared radiation, and that the gas is unusually warm and dense by astronomical standards, JPL said.Although the gas is at a chilly minus 63 degrees Fahrenheit ( minus 53 degrees Celsius) and is 300 trillion times less dense than Earth's atmosphere, it's still five times hotter and 10 to 100 times denser than what's typical in galaxies like the Milky Way, said JPL.Measurements of the water vapor and of other molecules, such as carbon monoxide, suggest there is enough gas to feed the black hole until it grows to about six times its size, JPL said.Whether this will happen is not clear, the astronomers say, since some of the gas may end up condensing into stars or might be ejected from the quasar.Bradford's team made their observations starting in 2008, using an instrument called "Z-Spec" at the California Institute of Technology's (Caltech's) Submillimeter Observatory, a 33-foot (10- meter) telescope near the summit of Mauna Kea in Hawaii. Follow-up observations were made with the Combined Array for Research in Millimeter-Wave Astronomy (CARMA), an array of radio dishes in the Inyo Mountains of Southern California.The second group, led by Dariusz Lis, senior research associate in physics at Caltech and deputy director of the Caltech Submillimeter Observatory, used the Plateau de Bure Interferometer in the French Alps to find water. In 2010, Lis's team serendipitously detected water in APM 8279+5255, observing one spectral signature.Bradford's team was able to get more information about the water, including its enormous mass, because they detected several spectral signatures of the water, according to JPL.

SHENZHEN, June 4 (Xinhua) -- Chinese scientists who have fully sequenced the genome of the new E. Coli spreading through Europe said Saturday they found genes in the bacteria that gave it resistance to eight classes of antibiotics.Researchers with the Beijing Genomics Institute, the world's largest DNA sequencing center, have found genes in the newly identified 0104 strain of E. Coli bacteria that made it resistant to major classes of antibiotics including sulfonamide, cephalothin, penicillin and streptomycin.This helped explain why doctors in Europe had difficulties in fighting the bug that has killed 18 people and sickened nearly 2,000, BGI's major research arm in Shenzhen said on its website Saturday.This would help doctors choose right medicines for the treatment, it said.The researchers are developing a diagnostic kit which will be used to detect the bacteria and prevent the epidemic from spreading further.The Chinese researchers obtained DNA samples of the bacteria from collaborating scientists in Germany and fully sequenced its genome in three days this week.They announced on Thursday the E. Coli spreading through Europe was "a new strain of bacteria that is highly infectious and toxic".The 0104 strain of E. Coli was not previously involved in any E. Coli outbreaks. However, it has 93 percent sequence similarity with the EAEC 55989 E. Coli strain which was isolated in the Central African Republic and known to cause seriously diarrhea, BGI said.The source of the outbreak is unknown, but scientists say it is highly likely to have originated in contaminated vegetables or salad in Germany.

SEOUL, Sept. 26 (Xinhua) -- Samsung Electronics, the world's second-largest manufacturer of mobile phones, launched its first smartphones based on fourth-generation (4G) communication technology in a bid to meet growing demand for high-speed wireless services. Galaxy S2 LTE and Galaxy S2 HD LTE compatible with long- term evolution (LTE) technology were rolled out at a media event held in central Seoul on Monday. The two new smartphones support LTE with data transmission five times faster than the existing third-generation (3G) mobile phones, featuring functions offered by Galaxy S2 smartphones, the company said.The Galaxy S2 LTE is equipped with an Android 2.3, or the latest version of the Android platform, a 4.5-inch wide Super AMOLED display and a 1.5 gigahertz dual core processor, while the Galaxy S2 HD LTE is featuring a 4.65-inch high-definition (HD) AMOLED display with 110 percent natural color reproduction and 180- degree viewing angle. "The 4G LTE technology became the base for enjoying high-speed and high-resolution wireless services. The new products will meet rising demand for such services in an environment where global wireless operators are transitioning to 4G networks," Shin Jong-kyun, president and head of Samsung's mobile communications business, told reporters.Shin forecast sales of the new LTE smartphones would approach the ones of the existing Galaxy S series, adding that it may take time to reach the goal as the LTE networks have yet to be covered nationwide.Global sales of the Galaxy S2 smartphones reached more than 10 million units since its debut in April, according Samsung. The nation's top wireless carrier SK Telecom plans to offer LTE service nationwide by 2013, with the country's No. 3 mobile operator LG Uplus aiming to cover the service across the country next year.